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Haemostatic Effects of Stress

  • Paul HjemdahlEmail author
  • Roland von Känel
Chapter
  • 1.8k Downloads

Abstract

The three major components of haemostasis – platelet activation, blood coagulation and fibrinolysis – are finely tuned to maintain flowing blood in the normal blood vessel, and yet stop bleeding and repair wounds when vessels are damaged. When the system is perturbed, arterial thrombosis may cause myocardial infarction (MI), stroke and other acute ischaemic events. Acute coronary events are often caused by atherosclerotic plaque rupture triggered by haemodynamic factors that increase wall stress and inflammatory weakening of the fibrous cap that covers the plaque.

Keywords

Haemostatic effects Pro-thrombotic mechanisms Anti-thrombotic mechanisms Platelets Blood coagulation Fibrinolysis Methodology Biomarkers Vital exhaustion 

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© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Department of Medicine, Solna, Clinical Pharmacology Unit, Karolinska InstituteKarolinska University Hospital/SolnaStockholmSweden
  2. 2.Department of General Internal Medicine, InselspitalBern University HospitalBernSwitzerland
  3. 3.Division of Psychosomatic Medicine, InselspitalBern University HospitalBernSwitzerland

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