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Social Stress and Cardiovascular Disease in Primates

  • Carol A. ShivelyEmail author
Chapter

Abstract

Atherosclerosis of the coronary arteries (CAA) and its complications are the ­principal pathological processes that result in coronary heart disease (CHD). Cynomolgus monkeys (Macaca fascicularis) are a well-characterized animal model of susceptibility to diet-induced atherogenesis. Cynomolgus monkeys imported as adults have little or no atherosclerosis.

Keywords

Social stress Coronary artery atherosclerosis Social reorganization Social isolation Social strangers Social status Cholesterol Ovarian function Ovariectomy Depression Autonomic nervous system Sympathetic nervous ­system Hypothalamic–pituitary–adrenal axis Visceral obesity Inuslin resistance Hyperglycemia Dyslipidemia Proinflammatory cytokines 

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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Department of Pathology/Comparative MedicineWake Forest University School of MedicineWinston-SalemUSA

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