Depression and Cardiovascular Disease Progression: Epidemiology, Mechanisms and Treatment

  • Petra HoenEmail author
  • Nina Kupper
  • Peter de JongeEmail author


Depression and coronary heart disease (CHD) are the two strongest contributors to the global burden of disease.1 Both disorders are common, and while cardiovascular disease is an important factor directly contributing to mortality, depression is primarily associated with decreased health-related quality of life,2 and imposes a significant economic burden on society.3 However, there are also signs that depression may contribute to higher mortality rates, perhaps due to its association with somatic disease, and in particular CHD.


Depression Cardiovascular disease progression Epidemiology Mechanisms Treatment Inflammation Platelet function Serotonin metabolism Screening 


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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Department of Interdisciplinary Center for Psychiatric EpidemiologyUniversity Medical Center GroningenGroningenThe Netherlands
  2. 2.Department of Medical Psychology, Center of Research on Psychology in Somatic DiseasesTilburg UniversityTilburgThe Netherlands

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