The growing field of regenerative medicine seeks to counteract injuries in which the body’s healing responses fail to respond with new functional tissue. To date, growth factors and cytokines have shown some clinical impact, by stimulating the production of new cells by the body or enhancing function of the existing cells in the body. Newer modalities, however, focus on the formation of new functional tissue substitutes for those lost. Regenerative technology, thus, has wide applications across multiple-organ systems and indeed the entire spectrum of disease processes. The restoration of functional tissue to heart and bone can theoretically provide treatment of congestive heart failure and osteoporosis. The formation of functional skin lessens the reliance on local and free plastic surgical flaps used in reconstruction and skin grafting. Generating neural tissue can treat disease states such as spina bifida. The regeneration of pancreatic tissue can be used to treat diabetes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abouna GM. Ethical issues in organ and tissue transplantation. Exp Clin Transplant. 2003;1(2):125–138
Al-Awqati Q, Oliver JA. Stem cells in the kidney. Kidney Int. 2002;61(2):387–395
Amiel GE, Yoo JJ, Atala A. Renal therapy using tissue-engineered constructs and gene delivery. World J Urol. 2000;18(1):71–79
Annas GJ, Elias S. The politics of transplantation of human fetal tissue. N Engl J Med. 1989;320(16):1079–1082
Assady S, Maor G, Amit M, et al Insulin production by human embryonic stem cells. Diabetes. 2001;50(8):1691–1697
Atala A. Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res. 2004;7(1):15–31
Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006;367(9518):1241–1246
Atala A, Retik AB, Schlussel RN. Renal cell growth in vivo after attachment to biodegradable polymer scaffolds. J Urol. 1995;153: 209A
Bent AE, Tutrone RT, McLennan MT, Lloyd LK, Kennelly MJ, Badlani G. Treatment of intrinsic sphincter deficiency using autologous ear chondrocytes as a bulking agent. Neurourol Urodyn. 2001;20(2):157–165
Chang TM. Bioencapsulation in biotechnology. Biomater Artif Cells Immobil Biotechnol. 1993;21(3):291–297
Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair. Urology. 1999;54(3): 407–410
Connolly SS, Yoo JJ, Abouheba M, Soker S, McDougal WS, Atala A. Cavernous nerve regeneration using acellular nerve grafts. World J Urol. 2008;26(4):333–339
De Filippo RE, Bishop CE, Filho LF, Yoo JJ, Atala A. Tissue engineering a complete vaginal replacement from a small biopsy of autologous tissue. Transplantation. 2008;86(2):208–214
De Filippo RE, Yoo JJ, Atala A. Urethral replacement using cell seeded tubularized collagen matrices. J Urol. 2002;168(4, pt 2): 1789–1792
De Filippo RE, Yoo JJ, Atala A. Engineering of vaginal tissue in vivo. Tissue Eng. 2003;9(2):301–306
Diamond DA, Caldamone AA. Endoscopic correction of vesicoureteral reflux in children using autologous chondrocytes: preliminary results. J Urol. 1999;162(3, pt 2):1185–1188
Dorin RP, Pohl HG, De Filippo RE, Yoo JJ, Atala A. Tubularized urethral replacement with unseeded matrices: what is the maximum distance for normal tissue regeneration? World J Urol. 2008;26(4): 323–326
Fissell WH, Humes HD, Roy S, Fleischman A. Initial characterization of a nanoengineered ultrafiltration membrane. J Am Soc Nephrol. 2002;13:602A
Fung L, Elenius K, Freeman MR, Donovan MJ, Atala A. Reconstitution of EGFr-poor renal epithelial cells into tubular structures on biodegradable polymer scaffold. Pediatrics. 1996;98S:631
Furlow WL. Surgical management of impotence using the inflatable penile prosthesis. Experience with 36 patients. Mayo Clin Proc. 1976;51(6):325–328
Giuliani S, Perin L, Sedrakyan S, Kokorowski P, Jin D, De Filippo R. Ex vivo whole embryonic kidney culture: a novel method for research in development, regeneration and transplantation. J Urol. 2008;179(1):365–370
Goldstein MB, Dearden LC, Gualtieri V. Regeneration of subtotally cystectomized bladder patched with omentum: an experimental study in rabbits. J Urol. 1967;97(4):664–668
Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med. 1998;338(20):1397–1404
Gooren LJ. A ten-year safety study of the oral androgen testosterone undecanoate. J Androl. 1994;15(3):212–215
Hendren WH, Reda EF. Bladder mucosa graft for construction of male urethra. J Pediatr Surg. 1986;21(3):189–192
Hogan DJ, Maibach HI. Adverse dermatologic reactions to transdermal drug delivery systems. J Am Acad Dermatol. 1990;22(5, pt 1):811–814
Joraku A, Stern KA, Atala A, Yoo JJ. In vitro generation of three-dimensional renal structures. Methods. 2008;47:129–133
Kambic H, Kay R, Chen JF, Matsushita M, Harasaki H, Zilber S. Biodegradable pericardial implants for bladder augmentation: a 2.5-year study in dogs. J Urol. 1992;148(2, pt 2):539–543
Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. 2001;98(19):10716–10721
Kehat I, Kenyagin-Karsenti D, Snir M, et al Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest. 2001;108(3): 407–414
Kelâmi A. Lyophilized human dura as a bladder wall substitute: experimental and clinical results. J Urol. 1971;105(4):518–522
Koch MO, McDougal WS, Hall MC, Hill DE, Braren HV, Donofrio MN. Long-term metabolic effects of urinary diversion: a comparison of myelomeningocele patients managed by clean intermittent catheterization and urinary diversion. J Urol. 1992;147(5):1343–1347
le Roux PJ. Endoscopic urethroplasty with unseeded small intestinal submucosa collagen matrix grafts: a pilot study. J Urol. 2005;173(1):140–143
Liguori G, Trombetta C, Bucci S, et al Laparoscopic mobilization of neovagina to assist secondary ileal vaginoplasty in male-to-female transsexuals. Urology. 2005;66(2):293–298, discussion 298
Machluf M, Orsola A, Boorjian S, Kershen R, Atala A. Microencapsulation of Leydig cells: a system for testosterone supplementation. Endocrinology. 2003;144(11):4975–4979
McDougal WS. Metabolic complications of urinary intestinal diversion. J Urol. 1992;147(5):1199–1208
Mitchell ME. The role of bladder augmentation in undiversion. J Pediatr Surg. 1981;16(6):790–798
Monga AK, Robinson D, Stanton SL. Periurethral collagen injections for genuine stress incontinence: a 2-year follow-up. Br J Urol. 1995;76(2):156–160
Oberpenning F, Meng J, Yoo JJ, Atala A. De novo reconstitution of a functional mammalian urinary bladder by tissue engineering. Nat Biotechnol. 1999;17(2):149–155
Oh SH, Ward CL, Atala A, Yoo JJ, Harrison BS. Oxygen generating scaffolds for enhancing engineered tissue survival. Biomaterials. 2008;30:752–762
Park HJ, Yoo JJ, Kershen RT, Moreland R, Atala A. Reconstitution of human corporal smooth muscle and endothelial cells in vivo. J Urol. 1999;162(3, pt 2):1106–1109
Pearman RO. Treatment of organic impotence by implantation of a penile prosthesis. J Urol. 1967;97(4):716–719
Perin L, Sedrakyan S, Da Sacco S, De Filippo R. Characterization of human amniotic fluid stem cells and their pluripotential capability. Methods Cell Biol. 2008;86:85–99
Rajimwale A, Furness PD 3rd, Brant WO, Koyle MA. Vaginal construction using sigmoid colon in children and young adults. BJU Int. 2004;94(1):115–119
Raya-Rivera AM, Baez C, Atala A, Yoo JJ. Tissue engineered testicular prostheses with prolonged testosterone release. World J Urol. 2008;26(4):351–358
Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000;18(4):399–404. Erratum in: Nat Biotechnol. 2000;18(5):559
Stein JP, Lieskovsky G, Ginsberg DA, Bochner BH, Skinner DG. The T pouch: an orthotopic ileal neobladder incorporating a serosal lined ileal antireflux technique. J Urol. 1998;159(6):1836–1842
Sokol RZ, Palacios A, Campfield LA, Saul C, Swerdloff RS. Comparison of the kinetics of injectable testosterone in eugonadal and hypogonadal men. Fertil Steril. 1982;37(3):425–430
Stenberg A, Läckgren G. A new bioimplant for the endoscopic treatment of vesicoureteral reflux: experimental and short-term clinical results. J Urol. 1995;154(2, pt 2):800–803
Takeda M, Katayama Y, Takahashi H, et al Incidence of pouch stones and risk factors for urolithiasis in patients with continent urinary diversion or neobladder using intestine. Urol Int. 1994;52(1): 21–25
Tumlin J, Wali R, Brennan K, Humes HD. Effect of the renal assist device (RAD)on mortality of dialysis-dependent acute renal failure: a randomized, open-labeled, multicenter, Phase II trial. J Am Soc Nephrol. 2005;16:46A (abstracts)
Watt SM, Contreras M. Stem cell medicine: umbilical cord blood and its stem cell potential. Semin Fetal Neonatal Med. 2005;10(3): 209–220
Yoo J, Ashkar S, Atala A. Creation of functional kidney structures with excretion of urine-like fluid in vivo. Pediatrics. 1996;98S:605
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag London
About this chapter
Cite this chapter
Chandrasoma, S., De Filippo, R. (2010). Tissue Bioengineering. In: Dasgupta, P., Fitzpatrick, J., Kirby, R., Gill, I.S. (eds) New Technologies in Urology. New Techniques in Surgery Series, vol 7. Springer, London. https://doi.org/10.1007/978-1-84882-178-1_17
Download citation
DOI: https://doi.org/10.1007/978-1-84882-178-1_17
Publisher Name: Springer, London
Print ISBN: 978-1-84882-177-4
Online ISBN: 978-1-84882-178-1
eBook Packages: MedicineMedicine (R0)