Abstract
Damaged and exposed endothelium allows: Platelet adherence to collagen, aggregation, and activation (via surface glycoprotein and vWF) with release of thomboxane A2, V, and vWF. Formation of “prothrombinase complex” (via VII and exposed tF) to produce initial thrombin. Amplification and activation of XI, IX, and VIII to activate V and produce more thrombin (“thrombin burst”). Thrombin polymerizes fibrinogen to form insoluble fibrin.
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Notes
- 1.
Erik Adolf von Willibrand (1870–1949) Finnish physician: described familial bleeding disorder in 1926.
- 2.
Jean-Baptiste Denis (1640–1704) – French court physician to Louis XIV: gave boy 9 ozs of lamb’s blood.
- 3.
James Blundell (1791–1878) – English obstetrician: transfused blood from husband to postpartum wife in 1829.
- 4.
Karl Landsteiner (1868–1943) – Austrian Nobel prize winner, who discovered both major blood group antigen systems and had time to discover the polio virus!
- 5.
Robin Coombs (1921–2006) – British immunologist.
- 6.
Heinz Gerhard Creutzfeldt (1885–1964) German neuropathologist.
- 7.
Alfons Maria Jakob (1884–1931) German neurologist.
- 8.
Daktylos (Greek) finger
- 9.
Priapus – minor Greek fertility god, always denoted with permanently erect penis.
Further Reading
Dick MC (2008) Standards for the management of sickle cell disease in children. Arch Dis Child (Ed Pract) 93:169–176
Firth PG (2005) Anaesthesia for peculiar cells–a century of sickle cell disease. Br J Anaesth 95:287–299
Stuart MI, Nagel RL (2004) Sickle-cell disease. Lancet 364:1343–60
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Davenport, M. (2010). Hematology for Surgeons. In: Sinha, C., Davenport, M. (eds) Handbook of Pediatric Surgery. Springer, London. https://doi.org/10.1007/978-1-84882-132-3_2.5
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