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The Biodistribution (I): Preclinical

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Nuclear Medicine Radiation Dosimetry

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Abstract

The measurement of the biodistribution of a radiopharmaceutical must be performed in the preclinical setting in order to provide an initial estimate of the internal radiation dosimetry of the human prior to the first-into-man Phase I study. This chapter summarizes both the means of how the preclinical biodistribution data are derived and how these data are scaled from the animal to the human. Crucial to any preclinical research are the ethics of animal use. This is also reviewed.

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Notes

  1. 1.

    Of course, preclinical studies of pharmacological safety are required in parallel.

  2. 2.

    Such as Octupus vulgaris in the European Union.

  3. 3.

    A strain of albino rat which is one of the most frequent used in biomedical research.

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Authors and Affiliations

  1. Amersham, Buckinghamshire, UK

    Brian J. McParland BASc MSc PhD

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  1. Brian J. McParland BASc MSc PhD
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McParland, B.J. (2010). The Biodistribution (I): Preclinical. In: Nuclear Medicine Radiation Dosimetry. Springer, London. https://doi.org/10.1007/978-1-84882-126-2_13

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  • DOI: https://doi.org/10.1007/978-1-84882-126-2_13

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