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Microcirculation of the Liver

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Venous Embolization of the Liver

Abstract

The microcirculation of the liver has important roles in maintenance of liver function. It guarantees the supply of the parenchymal tissue with oxygen and nutrients, serves as the gate for leukocyte entrance in hepatic inflammation, and is responsible for the clearance of toxic materials and foreign bodies from the bloodstream. The morphology and physiology of the hepatic microcirculation are described in this chapter to help the understanding of the physiology of the hepatic microcirculation.

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References

  1. Vollmar B, Menger MD. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev. 2009;89:1269-1339.

    Article  PubMed  CAS  Google Scholar 

  2. Lautt WW. Role and control of the hepatic artery. In: Lautt WW, ed. Hepatic Circulation in Health and Disease. New York: Raven; 1981:203-226.

    Google Scholar 

  3. Lautt WW et al. Quantitation of the hepatic arterial buffer response to graded changes in portal blood flow. Gastroenter­ology. 1990;98:1024-1028.

    Article  PubMed  CAS  Google Scholar 

  4. Lautt WW. Control of hepatic arterial blood flow: independence from liver metabolic activity. Am J Physiol Heart Circ Physiol. 1980;239:H559-H564.

    CAS  Google Scholar 

  5. Lautt WW. The hepatic artery: subservient to hepatic metabolism or guardian of normal hepatic clearance rates of humoral substances. Gen Pharmacol. 1977;8:73-78. Minireview.

    Article  PubMed  CAS  Google Scholar 

  6. Legare DJ, Lautt WW. Hepatic venous resistance site in the dog: localization and validation of intrahepatic pressure measurements. Can J Physiol Pharmacol. 1987;65:352-359.

    Article  PubMed  CAS  Google Scholar 

  7. Lautt WW et al. Adenosine as putative regulator of hepatic arterial flow (the buffer response). Am J Physiol Heart Circ Physiol. 1985;248:H331-H338.

    CAS  Google Scholar 

  8. Lautt WW, Legare DJ. The use of 8-phenyltheophylline as a competitive antagonist of adenosine and inhibitor of the intrinsic regulatory mechanism of the hepatic artery. Can J Physiol Pharmacol. 1985;63:717-722.

    Article  PubMed  CAS  Google Scholar 

  9. Cantré D et al. Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by increasing hepatic arterial flow. Br J Surg. 2008;95:785-792.

    Article  PubMed  Google Scholar 

  10. Hoetzel A et al. Nitric oxide-deficiency regulates hepatic heme oxygenase-1. Nitric Oxide. 2008;18:61-69.

    Article  PubMed  CAS  Google Scholar 

  11. Aoki T et al. Intraoperative direct measurement of hepatic arterial buffer response in patients with or without cirrhosis. Liver Transpl. 2005;11:684-691.

    Article  PubMed  Google Scholar 

  12. Mücke I et al. Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers. Int J Colorectal Dis. 2000;15:335-341.

    Article  PubMed  Google Scholar 

  13. Richter S et al. Impact of intrinsic blood flow regulation in cirrhosis: maintenance of hepatic arterial buffer response. Am J Physiol Gastrointest Liver Physiol. 2000;279:G454-G462.

    PubMed  CAS  Google Scholar 

  14. Demetris AJ et al. Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. Am J Surg Pathol. 2006;30:986-993.

    Article  PubMed  Google Scholar 

  15. Henderson JM et al. Hemodynamics during liver transplantation: the interactions between cardiac output and portal venous and hepatic arterial flows. Hepatology. 1992;16:715-718.

    Article  PubMed  CAS  Google Scholar 

  16. Smyrniotis V et al. Hemodynamic interaction between portal vein and hepatic artery flow in small-for-size split liver transplantation. Transpl Int. 2002;15:355-360.

    Article  PubMed  Google Scholar 

  17. Mathie RT et al. Liver blood flow: physiology, measurement and clinical relevance. In: Blumgart LH, ed. Surgery of the Liver and Biliary Tract. 2nd ed. New York: Churchill Livingstone; 1994:95-110.

    Google Scholar 

  18. McCuskey RS. Morphological mechanisms for regulating blood flow through hepatic sinusoids. Liver. 2000;20:3-7.

    Article  PubMed  CAS  Google Scholar 

  19. Oda M et al. Regulatory mechanisms of hepatic microcir­culatory hemodynamics: hepatic arterial system. Clin Hemorheol Microcirc. 2006;34:11-26.

    PubMed  Google Scholar 

  20. Oda M et al. Regulatory mechanisms of hepatic microcirculation. Clin Hemorheol Microcirc. 2003;29:167-182.

    PubMed  CAS  Google Scholar 

  21. Wisse E. An electron microscopic study of fenestrated endothelium lining of rat liver sinusoids. J Ultrastruct Res. 1970;31:125-150.

    Article  PubMed  CAS  Google Scholar 

  22. Wisse E et al. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 1985;5:683-692.

    Article  PubMed  CAS  Google Scholar 

  23. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88:125-172.

    Article  PubMed  CAS  Google Scholar 

  24. Rockey DC. Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis. 2001;21:337-349.

    Article  PubMed  CAS  Google Scholar 

  25. Rappaport AM, Wanless IR. Physioanatomic considerations. In: Schiff L, Schiff ER, eds. Diseases of the Liver. 6th ed. Philadelphia: JBLippincott Company; 1993:1-41.

    Google Scholar 

  26. Rentsch M et al. Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival. Transpl Int. 2005;18:1079-1089.

    Article  PubMed  CAS  Google Scholar 

  27. Vollmar B et al. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-­reperfusion. Am J Pathol. 1994;145:1421-1431.

    PubMed  CAS  Google Scholar 

  28. Le Minh K et al. Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin- in acute liver failure of mice. Am J Pathol. 2007;170:1954-1963.

    Article  PubMed  Google Scholar 

  29. Burkhardt M et al. The effect of estrogen on hepatic microcirculation after ischemia/reperfusion. Int J Colorectal Dis. 2008;23:113-119.

    Article  PubMed  CAS  Google Scholar 

  30. Brock RW et al. Microcirculatory perfusion deficits are not essential for remote parenchymal injury within the liver. Am J Physiol Gastrointest Liver Physiol. 1999;277:G55-G60.

    CAS  Google Scholar 

  31. Braide M et al. Quantitative studies on the influence of leukocytes on the vascular resistance in a skeletal muscle preparation. Microvasc Res. 1984;27:331-352.

    Article  PubMed  CAS  Google Scholar 

  32. Menger MD et al. Role of microcirculation in hepatic ischemia/reperfusion injury. Hepatogastroenterology. 1999;46(suppl 2):1452-1457.

    PubMed  Google Scholar 

  33. Oda M et al. Endothelial cell dysfunction in microvasculature: relevance to disease processes. Clin Hemorheol Microcirc. 2000;23:199-211.

    PubMed  CAS  Google Scholar 

  34. Villeneuve JP et al. The hepatic microcirculation in the ­isolated perfused human liver. Hepatology. 1996;23:24-31.

    Article  PubMed  CAS  Google Scholar 

  35. Onori P et al. Hepatic microvascular features in experimental cirrhosis: a structural and morphometrical study in CCl4-treated rats. J Hepatol. 2000;33:555-563.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul, 138-736, South Korea

    Shin Hwang

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  1. Shin Hwang
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Correspondence to Shin Hwang .

Editor information

Editors and Affiliations

  1. New York-Presbyterian Hospital, New York, 10032, New York, USA

    David C. Madoff

  2. University of Tokyo, Hongo 7-3-1, Tokyo, 113-8656, Japan

    Masatoshi Makuuchi

  3. School of Medicine, Dept. Surgery I, Nagoya University, Tsurumai-cho 65, Nagoya, Aichi-ken, 466-8550, Japan

    Masato Nagino

  4. M.D. Anderson Cancer Center, Dept. Surgical Oncology, University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Jean-Nicolas Vauthey

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Hwang, S. (2011). Microcirculation of the Liver. In: Madoff, D., Makuuchi, M., Nagino, M., Vauthey, JN. (eds) Venous Embolization of the Liver. Springer, London. https://doi.org/10.1007/978-1-84882-122-4_2

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  • DOI: https://doi.org/10.1007/978-1-84882-122-4_2

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-121-7

  • Online ISBN: 978-1-84882-122-4

  • eBook Packages: MedicineMedicine (R0)

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