Abstract
Severe acute pancreatitis is associated with the development of the systemic inflammatory response syndrome (SIRS).
Hypoxemia is a hallmark of acute pancreatitis and respiratory failure is the most common single organ failure in this disease. In the most severely ill patients multi-organ dysfunction syndrome (MODS) and multi-organ failure (MOF) occur. Intensive care with multiple organ support is necessary.
In this review, we have considered the key issues relevant to acute pancreatitis in the intensive care unit (ICU). We have identified areas that may merit further research, specifically in patients with severe acute pancreatitis, who are receiving intensive care or have a high risk of developing multi-organ failure.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Al-Omran M, Groof A, Wilke D (2006) Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 4
Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871
ARDSnet (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and acute respiratory distress syndrome. New Engl J Med 342:1301-1308
Eatock FC, Chong P, Menezes N et al (2005) A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 100(2):432-439
Eggimann P, Jamdar S, Siriwardena AK (2006) Antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics. Crit Care 10(5):229
Garcea G, Jackson B, Pattenden C, Sutton C, Neal C, Dennison AR, Berry D (2006) Early warning scores predict outcome in acute pancreatitis. J Gastr Surg 10(7):1008-1015
Jamdar S, Siriwardena A (2005) Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis. Crit Care 9(4):321-322
Kalfarentzos F, Kehagias J, Mead N et al (1997) Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 84(12):1665-1669
Liu N, Ying MY, Ying L (2006) Upper gastrointestinal and pancreatic diseases group lexipafant for acute pancreatitis. Cochrane Database Syst Rev 4
Olah A, Pardavi G, Belagyi T et al (2002) Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate. Nutrition 18(3):259-262
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. New Engl J Med 345:1368-1377
Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356(9223):26-30
The National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network (2006) Comparison of two fluid-management strategies in acute lung injury. New Engl J Med 354:2564-2575
The SAFE study investigators (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. New Engl J Med 350:2247-2256
Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in critically ill patients. New Engl J Med 345:1359-1367
Villatoro E, Bassi C, Larvin M (2006) Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 18;(4) CD002941
Vinsonneau C, Camus C, Combes A, Costa de Beauregard MA, Klouche K, Boulain T, Pallot JL, Chiche JD, Taupin P, Landais P, Dhainaut JF (2006) on behalf of the Hemodiafe Study Group. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple organ dysfunction syndrome: a multicentre randomised trial. Lancet 368:379-385
Wang Hao, Li Wei-Qin, Zhou Wei, Li Ning, Li Jie-Shou (2003) Clinical effects of continuous high volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome. World J Gastroenterol 9(9):2096-2099
Windsor AC, Kanwar S, Li AG et al (1998) Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 42(3):431-435
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag London Limited
About this chapter
Cite this chapter
Kinsella, J., Clements, B., Dickson, E., Dugernier, T., Hughes, M. (2010). Acute Pancreatitis in Intensive Care. In: Johnson, C., Imrie, C. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-84882-118-7_1
Download citation
DOI: https://doi.org/10.1007/978-1-84882-118-7_1
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-84882-117-0
Online ISBN: 978-1-84882-118-7
eBook Packages: MedicineMedicine (R0)