Skip to main content
SpringerLink
Log in

Recent Advances in the Management of Acute Ischemic Stroke

  • Chapter
  • First Online:
Neurocritical Care

Part of the book series: Competency-Based Critical Care ((CBCC))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, Colman PG, Chambers BR, Davis SM (2003) Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 34:2208–2214

    Article  CAS  PubMed  Google Scholar 

  • Berg-Dammer E, Felber SR, Henkes H, Nahser HC, Kuhne D (2000) Long-term outcome after local intra-arterial fibrinolysis of basilar artery thrombosis. Cerebrovasc Dis 10:183–188

    Article  CAS  PubMed  Google Scholar 

  • Blanco M, Nombela F, Castellanos M, Rodriguez-Yáñez M, García-Gil M, Leira R, Lizasoain I, Serena J, Vivancos J, Moro MA, Dávalos A, Castillo J (2007) Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology 69:904–910

    Article  CAS  PubMed  Google Scholar 

  • Bonita R (1992) Epidemiology of stroke. Lancet 339:342–344

    Article  CAS  PubMed  Google Scholar 

  • Chen ZM, Sandercock P, Pan HC, Counsell C, Collins R, Liu LS, Xie JX, Warlow C, Peto R (2000) Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups. Stroke 31:1240–1249

    CAS  PubMed  Google Scholar 

  • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S (1999) Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 282:2019–2026

    Article  CAS  PubMed  Google Scholar 

  • Clark WM, Albers GW, Madden KP, Hamilton S (2000) The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Thrombolytic therapy in acute ischemic stroke study investigators. Stroke 31:811–816

    CAS  PubMed  Google Scholar 

  • Coull AJ, Lovett JK, Rothwell PM (2004) Population based study of early risk of stroke after transient ischemic attack or minor stroke: implications for public education and organisation of services. BMJ 328:326

    Article  CAS  PubMed  Google Scholar 

  • Department of Health (2005) Reducing brain damage: Faster access to better stroke care. National Audit Office Report

    Google Scholar 

  • Furlan M, Marchal G, Viader F, Derlon JM, Baron JC (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40:216–226

    Article  CAS  PubMed  Google Scholar 

  • Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA 282:2003–2011

    Article  CAS  PubMed  Google Scholar 

  • Georgiadis D, Schwarz S, Aschoff A, Schwab S (2002) Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke. Stroke 33:1584–1588

    Article  CAS  PubMed  Google Scholar 

  • Gray CS, Hildreth AJ, Sandercock PA, O’Connell JE, Johnston DE, Cartlidge NE, Bamford JM, James OF, Alberti KG (2007) Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK glucose insulin in stroke trial (GIST-UK). Lancet Neurol 6:397–406

    Article  CAS  PubMed  Google Scholar 

  • Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017–1025

    Article  CAS  PubMed  Google Scholar 

  • Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P (1998) Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischemic stroke (ECASS II). Second European-Australasian acute stroke study investigators. Lancet 352:1245–1251

    Article  CAS  PubMed  Google Scholar 

  • Hacke W, Kaste M, Bogousslavsky J, Brainin M, Chamorro A, Lees K, Leys D, Kwiecinski H, Toni P, Langhorne P, Diener C, Hennerici M, Ferro J, Sivenius J, Gunnar N, Bath P, Olsen TS, Gugging M (2003) European stroke initiative recommendations for stroke management-update 2003. Cerebrovasc Dis 16:311–337

    Article  Google Scholar 

  • Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363:768–774

    Article  PubMed  Google Scholar 

  • Hacke W, Albers G, Al Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, Fischer M, Furlan A, Kaste M, Lees KR, Soehngen M, Warach S (2005) The desmoteplase in acute ischemic stroke trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 36:66–73

    Article  CAS  PubMed  Google Scholar 

  • Hajat C, Hajat S, Sharma P (2000) Effects of poststroke pyrexia on stroke outcome : a meta-analysis of studies in patients. Stroke 31:410–414

    CAS  PubMed  Google Scholar 

  • Hakim AM (1987) The cerebral ischemic penumbra. Can J Neurol Sci 14:557–559

    CAS  PubMed  Google Scholar 

  • Johnston SC, Rothwell PM, Nguyen-Huynh MN, Giles MF, Elkins JS, Bernstein AL, Sidney S (2007) Validation and refinement of scores to predict very early stroke risk after transient ischemic attack. Lancet 369:283–292

    Article  PubMed  Google Scholar 

  • Kogure T, Kogure K (1997) Molecular and biochemical events within the brain subjected to cerebral ischemia (targets for therapeutical intervention). Clin Neurosci 4:179–183

    CAS  PubMed  Google Scholar 

  • Langhorne P, Tong BL, Stott DJ (2000) Association between physiological homeostasis and early recovery after stroke. Stroke 31:2518–2519

    CAS  PubMed  Google Scholar 

  • Lovett JK, Dennis MS, Sandercock PA, Bamford J, Warlow CP, Rothwell PM (2003) Very early risk of stroke after a first transient ischemic attack. Stroke 34:e138–e140

    Article  Google Scholar 

  • Lovett JK, Coull AJ, Rothwell PM (2004) Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies. Neurology 62:569–573

    CAS  PubMed  Google Scholar 

  • Muir KW, Lees KR, Ford I, Davis S (2004) Intravenous Magnesium Efficacy in Stroke (IMAGES) Study Investigators. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 363:439–445

    Article  CAS  PubMed  Google Scholar 

  • Nadeau JO, Shi S, Fang J, Kapral MK, Richards JA, Silver FL, Hill MD (2005) TPA use for stroke in the Registry of the Canadian stroke network. Can J Neurol Sci 32:433–439

    PubMed  Google Scholar 

  • National Stroke Strategy, Department of Health (2007). http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_081062

  • Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ (2004) Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363:915–924

    Article  CAS  PubMed  Google Scholar 

  • Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, Lovelock CE, Binney LE, Bull LM, Cuthbertson FC, Welch SJ, Bosch S, Alexander FC, Silver LE, Gutnikov SA, Mehta Z (2007) Early use of Existing Preventive Strategies for Stroke (EXPRESS) study. Effect of urgent treatment of transient ischemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 370:1432–1442

    Article  PubMed  Google Scholar 

  • Schrader J, Luders S, Kulschewski A, Berger J, Zidek W, Treib J, Einhaupl K, Diener HC, Dominiak P (2003) The ACCESS Study: evaluation of Acute Candesartan Cilexetil therapy in stroke survivors. Stroke 34:1699–1703

    Article  PubMed  Google Scholar 

  • Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW, Emeribe U (2007) SAINT II Trial Investigators. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 357:562–571

    Article  CAS  PubMed  Google Scholar 

  • Steiner T, Mendoza G, De Georgia M, Schellinger P, Holle R, Hacke W (1997) Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit. Stroke 28:711–715

    CAS  PubMed  Google Scholar 

  • Stroke Unit Trialists’ Collaboration (2000) Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev 2:CD000197

    Google Scholar 

  • Sulter G, Elting JW, Langedijk M, Maurits NM, De Keyser J (2003) Admitting acute ischemic stroke patients to a stroke care monitoring unit versus a conventional stroke unit: a randomized pilot study. Stroke 34:101–104

    Article  PubMed  Google Scholar 

  • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587

    Article  Google Scholar 

  • Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W, DECIMAL, DESTINY, and HAMLET investigators (2007) Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 6:215–222.

    Google Scholar 

  • Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G, SITS-MOST investigators (2007) Thrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of thrombolysis in stroke-monitoring study (SITS-MOST): an observational study. Lancet 369:275-282

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Leeds General Infirmary Leeds Teaching Hospitals NHS Trust, Leeds, West Yorkshire, LS1 3EX, UK

    Ahamad Hassan

Authors
  1. Ahamad Hassan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, United Kingdom

    John P. Adams

  2. Dept. Anaesthesia, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, United Kingdom

    Dominic Bell

  3. Leeds General Infirmary, Gt. George Street, Leeds, LS1 3EX, United Kingdom

    Justin McKinlay

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag London Limited

About this chapter

Cite this chapter

Hassan, A. (2010). Recent Advances in the Management of Acute Ischemic Stroke. In: Adams, J., Bell, D., McKinlay, J. (eds) Neurocritical Care. Competency-Based Critical Care. Springer, London. https://doi.org/10.1007/978-1-84882-070-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-84882-070-8_7

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-069-2

  • Online ISBN: 978-1-84882-070-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation