Abstract
The hallmark of Cogan's syndrome is the presence of ocular inflammation and audiovestibular dysfunction. These findings may be accompanied by the evidence of a systemic vasculitis that involves large blood vessels. Interstitial keratitis is the most common form of ocular involvement. Audiovestibular dysfunction may lead to the acute onset of vertigo, tinnitus, nausea, and vomiting. Vasculitis in Cogan's syndrome may take the form of aortitis, renal artery stenosis, or occlusion of the great vessels.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Davis MD, Brewer JD. Urticarial vasculitis and hypocomplementemic urticarial vasculitis syndrome. Immunol Allergy Clin North Am 2004;24:183
Davis MDP, Daoud MS, Kirby B, et al Clinicopathologic correlation of hypocomplementemic and normocomplementemic urticarial vascu-litis. J Am Acad Dermatol 1998;38:899
Gibson LE, El-Azhary RA. Erythema elevatum diutinum. Clin Dermatol 2000;18:295–99
Gluth MB, Baratz KH, Matteson EL, et al Cogan's syndrome: a retrospective review of 60 patients throughout a half-century. Mayo Clin Proc 2006;81:483–8
Grasland A, Pouchot P, Hachulla E, et al Typical and atypical Cogan's syndrome: 32 cases and review of the literature. Rheumatology 2004;43:1007–15
Mazlumzadeh M, Matteson EL. Cogan's syndrome: an audiovestibular, ocular, and systemic autoimmune disease. Rheum Dis Clin North Am 2007;33:855–74
Mehregan DR, Hall MJ, Gibson LE. Urticarial vasculitis: a histopatho-logic and clinical review of 72 cases. J Am Acad Dermatol 1992;26(3 Pt 2):441–8
Pafanisi, Pafanisi E, Vincenti V, et al Cochlear implantation and Cogan's syndrome. Otol Neurotol 2003;24:601–4
Riente L, Taglione E, Berrettini S. Efficacy of methotrexate in Cogan's syndrome. J Rheumatol 1996;23:1830–1
Sunderkötter C, Bonsmann G, Sindrilaru A, et al Management of leuko-cytoclasticvasculitis. J Dermatol Treat 2005;16:193–206
Toppe E, Haas N, Henz BM. Neutrophilic urticaria: clinical features, histologic changes, and possible mechanisms. Br J Dermatol 1998;138:248–53
Vollertsen R, McDonald T, Younge B, et al Cogan's syndrome: 18 cases and a review of the literature. Mayo Clin Proc 1986;61: 344–61
Wahl CE, Bouldin MB, Gibson LE. Erythema elevatum diutinum: clinical, histopathologic, and immunohistochemical characteristics of six patients. Am J Dermatopathol 2005;27:397–400
Wisnieski JJ, Baer AN, Christensen J, et al Hypocomplementemic urti-carial vasculitis syndrome: clinical and serologic findings in 18 patients. Medicine 1995;74:24–41
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Matteson, E.L., Stone, J.H. (2009). Less Common Forms of Vasculitis. In: Stone, J.H. (eds) A Clinician's Pearls and Myths in Rheumatology. Springer, London. https://doi.org/10.1007/978-1-84800-934-9_31
Download citation
DOI: https://doi.org/10.1007/978-1-84800-934-9_31
Publisher Name: Springer, London
Print ISBN: 978-1-84800-933-2
Online ISBN: 978-1-84800-934-9
eBook Packages: MedicineMedicine (R0)