Children with inflammatory myopathies have clinical and laboratory features, as well as risk factors and outcomes that overlap with their adult counterparts. However, a number of important differences exist between pediatric and adult disease. Juvenile dermatomyositis (JDM), the most common of this group of illnesses in children, has an incidence of approximately 3.2 cases/million children/year. JDM has a gender ratio of 2 girls:1 boy. JDM has a mean age of 6.7 years at disease onset. The duration of active disease before the time of diagnosis alters the patients' features at presentation as well as their clinical outcomes. Environmental and genetic factors affect the child's susceptibility to these conditions and also alter the inflammatory response, adding heterogeneity to disease pathophysiology.
KeywordsCeliac Disease Juvenile Idiopathic Arthritis Interstitial Lung Disease Mixed Connective Tissue Disease Inflammatory Myopathy
- Feldman BM, Ravelli A. Maintaining flexibility: Joints and other considerations. In: LG Rider, LM Pachman, FW Miller, H Bollar (eds) Myositis and you: A guide to juvenile dermatomyositis for patients, families and health care providers. The Myositis Association; 2007:269–274Google Scholar
- Lopez de Padilla CM, Vallejo AN, McNallan KT, et al Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermato-myositis. Arthritis Rheum 2007; 56(5):1658–1668Google Scholar
- Mamyrova G., O'Hanlon TP, Sillers L, et al, for the Childhood Myositis Heterogeneity Collaborative Study Group. Cytokine gene polymorphisms as risk and severity factors for Juvenile Dermatomyositis. Arthritis Rheum 2008; 58(12):3941–50Google Scholar
- Miller, FW. Inflammatory myopathies: Polymyositis, dermatomyositis, and related conditions. In: Koopman W, Moreland L (eds) Arthritis and allied conditions — A textbook of rheumatology (15th edn, volume 2). Philadelphia, PA, Lippincott Williams & Wilkins, 2005, pp. 1593–1620Google Scholar
- Pilkington C, Reed AM. When your child has more than one autoimmune disease. In: Rider LG, Pachman LM, Miller FW, Bollar H (eds) Myositis and you (1st edn), Addition. Washington DC, The Myositis Association, 2007, pp. 321–326Google Scholar
- Rouster-Stevens KA, Pachman LM. Autoantibody to signal recognition particle in African-American girls. J Rheumatol 35:927–929, 2008Google Scholar