Randomness is a concept deeply entangled with bioinformatics. A random sequence cannot convey information, in the sense that it could be generated by a recipient merely by tossing a coin. Randomness is therefore a kind of “null hypothesis”; a random sequence of symbols is a sequence lacking all contraints limiting the variety of choice of successive symbols selected from a pool with constant composition (i.e., an ergodic source). Such a sequence has maximum entropy in the Shannon sense; that is, it has minimum redundancy.
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© 2009 Springer-Verlag London
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Ramsden, J.J. (2009). Randomness and complexity. In: Bioinformatics. Computational Biology, vol 10. Springer, London. https://doi.org/10.1007/978-1-84800-257-9_6
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DOI: https://doi.org/10.1007/978-1-84800-257-9_6
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