Metabolomics and Metabonomics
Metabolism is the ensemble of chemical transformations carried out in living tissue (§10.2); operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (\(M_r \lesssim 1000\); e.g., glucose, cAMP, GMP, glutamate, etc.) transformed in the process of metabolism (i.e., mostly the substrates and products of enzymes). The quantification of the amounts of expressed enzymes is, as we have seen, proteomics; metabolomics is essentially an extension of proteomics to the activities of the expressed enzymes, and it is of major interest to examine correlations between expression data and metabolite data.
KeywordsMetabolic Network Enzyme Commission Guanosine Monophosphate Small World Property Metabolic Control Analysis
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