Metabolism is the ensemble of chemical transformations carried out in living tissue (ยง10.2); operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (\(M_r \lesssim 1000\); e.g., glucose, cAMP, GMP, glutamate, etc.) transformed in the process of metabolism (i.e., mostly the substrates and products of enzymes). The quantification of the amounts of expressed enzymes is, as we have seen, proteomics; metabolomics is essentially an extension of proteomics to the activities of the expressed enzymes, and it is of major interest to examine correlations between expression data and metabolite data.
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ยฉ 2009 Springer-Verlag London
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Ramsden, J.J. (2009). Metabolomics and Metabonomics. In: Bioinformatics. Computational Biology, vol 10. Springer, London. https://doi.org/10.1007/978-1-84800-257-9_16
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DOI: https://doi.org/10.1007/978-1-84800-257-9_16
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