Abstract
To choose from the literature only ten papers on the heart and circulation that have been important to the development of contemporary intensive care is a daunting task. Inevitably, to many readers the choice will appear partial and unbalanced. The contributions have been selected on the basis of their importance to clinical practice in two areas relevant to intensive care: first, the function of the heart in generating the cardiac output and maintaining oxygen delivery to the tissues, and second, the influence of respiratory factors on the circulation, which is particularly relevant to the management of the mechanically-ventilated patient. Consequently, this selection may puzzle cardiologists, as there is no reference to coronary arteries, revascularization procedures, or ischemic pre-conditioning. Since the focus is the heart and the central circulation, recent advances in our understanding of vascular biology, the endothelium, and the role of mediators such as nitric oxide, prostaglandins, and cytokines in determining normal and pathological vascular responses, are also excluded.
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Treacher, D.F. (2008). The Heart. In: Fink, M., Hayes, M., Soni, N. (eds) Classic Papers in Critical Care. Springer, London. https://doi.org/10.1007/978-1-84800-145-9_3
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DOI: https://doi.org/10.1007/978-1-84800-145-9_3
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