Pharmacological manipulation of afterload or systemic vascular resistance (SVR) has become increasingly important in the management of pediatric cardiac patients, just as it has for adult cardiac patients.
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References
Chobarian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 2003; 289:2560–2572.
von Vigier RO, Mozzetti S, Truttmann AC, et al. Cough is Common in Children Prescribed Converting Enzyme Inhibitors. Nephron 2000; 84:98.
References
Chobarian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 2003; 289:2560–2572.
Leversha AM, Wilson NJ, Clarkson PM, et al. Efficacy and Dosage of Enalapril in Congenital and Acquired Heart Disease. Arch Dis Child 1994; 70:35.
Marcadis ML, Kraus DM, Hatzopoulos FK, et al. Use of Enalaprilat for Neonatal Hypertension. J Pediatr 1991; 119:505.
von Vigier RO, Mozzetti S, Truttmann AC, et al. Cough is Common in Children Prescribed Converting Enzyme Inhibitors. Nephron 2000; 84:98.
References
Chase SL, Sutton JD. Lisinopril: A New Angiotensin-Converting Enzyme Inhibitor. Pharmacotherapy 1989; 9:120.
References
Epstein BJ, Gums JG. Angiotensin Receptor Blockers Versus ACE Inhibitors: Prevention of Death And Myocardial Infarction in High-Risk Populations. Ann Pharmacother 2005; 39:470–480.
Ellis D, Moritz ML, Vats A, Janosky JE. Antihypertensive and Renoprotective Efficacy and Safety of Losartan. A Long-Term Study in Children with Renal Disorders. Am J Hypertens 2004; 7:928–935.
Cozaar® (Losartan potassium). In Physicians’ Desk Reference. 60th Edition. Thomson PDR, Montvale, New Jersey. 2006. pp. 1213–1918.
References
Flynn JT, Pasko DA. Calcium Channel Blockers: Pharmacology and Place in Therapy of Pediatric Hypertension. Pediatr Nephrol 2000; 15:302.
References
Flynn JT, Smoyer WE, Bunchman TE. Treatment of Hypertensive Children with Amlodipine. Am J Hypertens 2000; 13:1061–1066.
Tallian KB, Nahata MC, Turman MA, et. al. Efficacy of Amlodipine in Pediatric Patients with Hypertension. Pediatr Nephrol 1999; 13:304–310.
References
Tobias JD. Nicardipine to Control Mean Arterial Pressure After Cardiothoracic Surgery in Infants and Children. Am J Ther 2001; 8:3–6.
Milou C, Debuche-Benouachkou V, Semama DS, et al. Intravenous Nicardipine as a First-Line Antihypertensive Drug in Neonates. Intensive Care Med 2000; 26:956–958.
Gouyon JB, Geneste B, Semama DS, et al. Intravenous Nicardipine in Hypertensive Preterm Infants. Arch Dis Child Fetal Neonatal Ed 1997; 76:F126–127.
References
Corwin S, Reiffel JA. Nitrate Therapy for Angina Pectoris. Arch Int Med 1985; 145:538.
Elkayam V. Tolerance to Organic Nitrates: Mechanisms, Clinical Relevance, and Strategies for Prevention. Ann Int Med 1991; 114:667–677.
Taketomo CK, Hodding JH, Kraus DM. Lexi-Comp’s Pediatric Dosage Handbook, 13th Edition, 2006.
References
Palmer RF, Lasseter KC. Drug Therapy: Sodium Nitroprusside. N Engl J Med 1975; 292:294–297.
Vessey CJ, Cole PV. Blood Cyanide and Thiocyanate Concentrations Produced by Long-Term Therapy with Sodium Nitroprusside. Br J Anaesth 1985; 57:148–155.
References
Tobias JD. Preoperative blood pressure management of children with cathecholamine-secreting tumors: time for a change. Pediatr Anesth 2005; 15:537–540.
Kawamura M, Minamikawa O, Yokochi H, Maki S, Yasuda T, Mizukawa Y. Combined use of phenoxybenzamine and dopamine for low cardiac output syndrome in children at withdrawal from cardiopulmonary bypass. Br Heart J 1980; 43:388–392.
Kulik A, Rubens FD, Gunning D, Bourke ME, Mesana TG, Ruel M. Radial artery graft treatment with phenoxybenzamine is clinically safe and may reduce perioperative myocardial injury. Ann Thorac Surg 2007; 83:502–509.
Kiran U, Zuber K, Kakani M. Combination of low-dose phenoxybenzamine and sodium nitroprusside in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2006; 20:291–292.
Kiran U, Makhija N, Das SN, Bhan A, Airan B. Combination of phenoxybenzamine and nitroglycerin: effective control of pulmonary artery pressures in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2005; 19:274–275.
Motta P, Mossad E, Toscaca D, Zestos M, Mee R. Comparison of phenoxybenzamine to sodium nitroprusside in infants undergoing surgery. J Cardiothorac Vasc Anesth 2006; 20:291–292.
Motta P, Mossad E, Toscana D, Zestos M, Mee R. Comparison of phenoxybenzamine to sodium nitroprusside in infants undergoing surgery. J Cardiothorac Vasc Anesth 2005; 19: 54–59.
Li DM, Mullaly R, Ewer P, Bell B, Eyres RL, Brawn WJ, Mee RB. Effects of vasodilators on rates of change of nasopharyngeal temperature and systemic vascular resistance during cardiopulmonary bypass in anaesthetized dogs. Aust N Z J Surg 1988; 58:327–333.
De Oliveira NC, Ashburn DA, Khalid F, Burkhart HM, Adatia IT, Holtby HM, Williams WG, Van Arsdell GS. Prevention of early sudden circulatory collapse after the Norwood operation. Circulation 2004; 110(Suppl 1):II133–138.
De Oliveira NC, Van Arsdell GS. Practical use of alpha blockade strategy in the management of hypoplastic left heart syndrome following stage one palliation with a Blalock-Taussig shunt. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004: 7:11–15.
O’Blenes SB, Roy N, Konstantinov I, Bohn D, Van Arsdell GS. Vasopressin reversal of phenoxybenzamine-induced hypotension after the Norwood procedure. J Thorac Cardiovasc Surg 2002; 123:1012–1013.
Kiran U, Makhija N, Das SN, Bhan A, Airan B. Combination of phenoxybenzamine and nitroglycerin: effective control of pulmonary artery pressures in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 2005; 19:274–275.
Weiner N: Drugs that inhibit adrenergic nerves and block adrenergic receptors. In: Goodman & Gillman, The Pharmacological Basis of Therapeutics, 6th Edition, New York, MacMillan Publishing Co, 1980. pp. 179–182.
O’Blenes SB, Roy N, Konstantinov I, Bohn D, Van Arsdell GS. Vasopressin reversal of phenoxybenzamine-induced hypotension after the Norwood procedure. J Thorac Cardiovasc Surg 2002; 123:1012–1013.
References
Tuncel M, Ram VC. Hypertensive emergencies. Etiology and management. Am J Cardiovasc Drugs 2003; 3:21–31.
Murphy DJ, Walker ME, Culp DA, Francomacaro DV. Effects of adrenergic antagonists on cocaine-induced changes in respiratory function. Pulm Pharmacol 1991; 4:127–134.
Koner O, Tekin S, Koner A, Soybir N, Seren S, Karaoglu K. Effects of phentolamine on tissue perfusion in pediatric cardiac surgery. J Cardiothorac Vasc Anesth 1999; 13:191–197.
Molony D. Adrenaline-induced digital ischaemia reversed with phentolamine. ANZ J Surg. 2006; 76:1125–1126.
Galal MO, El-Naggar WI, Sharfi MH. Phentolamine as a treatment for poor mixing in transposition of the great arteries with adequate intra atrial communication. Pediatr Cardiol 2005; 26:444–445.
McPherson GA. Current trends in the study of potassium channel openers. Gen Pharmacol 1993; 24:275–281.
References
Post JB 4th, Frishman WH. Fenoldopam: a new dopamine agonist for the treatment of hypertensive urgencies and emergencies. J Clin Pharmacol 1998; 38(1):2–13.
White WB, Radfod MJ, Gonzales FM, et al. Selective dopamine-1 agonist therapy in severe hypertension: effects of intravenous fenoldopam. J Am Coll Cardiology 1988; 11:1118–1121.
Bednzarczyk EM, White WB, Munger MA, et al. Comparative acute blood pressure reduction from intravenous fenoldopam mesylate versus sodium nitroprusside in severe systemic hypertension. Am J Cardiology 1989; 63:993–996.
References
Zahka KG, Roland MA, Cutilletta AF, et al. Management of aortic arch interruption with prostaglandin E1 infusion and microporous expanded polytetrafluoroethylene grafts. Am J Cardiol 1980; 46:1001–1005.
Peled N, Dagan O, Babyn P, et al. Gastric-outlet obstruction induced by prostaglandin therapy in neonates. N Engl J Med 1992; 327:505–510.
Woo K, Emery J, & Peabody J. Cortical hyperostosis: a complication of prolonged prostaglandin infusion in infants awaiting cardiac transplantation. Pediatrics 1994; 93: 417–420.
Kalloghlian AK, Frayha HH, deMoor MM. Cortical hyperostosis simulating osteomyelitis after short-term prostaglandin E1 infusion. Eur J Pediatr 1996; 155(3):173–174.
References
Bennett WM, Aronoff GR, Golper TA, et al. Drug Prescribing in Renal Failure. American College of Physicians, Philadelphia, PA, 1994.
Russell GI, Bing RF, Jones JA, et al. Hydralazine sensitivity: clinical features, autoantibody changes and HLA-DR phenotype. Q J Med 1987; 65:845–852.
Cinquegrani MP, Liang CS. Indomethacin attenuates the hypotensive action of hydralazine. Clin Pharmacol Ther 1986; 39:564–570.
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Roth, S.J., Munoz, R., Schmitt, C.G., da Cruz, E., Kaufman, J., Tissot, C. (2008). Vasodilators. In: Munoz, R., Schmitt, C.G., Roth, S.J., da Cruz, E. (eds) Handbook of Pediatric Cardiovascular Drugs. Springer, London. https://doi.org/10.1007/978-1-84628-953-8_4
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