Alteplase is used for treatment of acute myocardial infarction (MI), acute ischemic stroke, acute, massive pulmonary embolism, and occluded central venous catheters. Alteplase has also been used in pediatric patients with systemic thrombosis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Monagle P, Chan A, Massicotte P, et al. Antithrombotic therapy in children: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 645S–687S.
Monagle P, Michelson AD, Bovill E, et al. Antithrombotic therapy in children. Chest 2001; 119: 344S–370S.
Balaguru D, Dilawar M, Ruff P, Radtke WA. Early and late results of thrombolytic therapy using tissue-type plasminogen activator to restore arterial pulse after cardiac catheterization in infants and small children. Am J Cardiol 2003; 91(7): 908–910.
Duncan BW, Hraska V, Jonas RA, Wessel DL, del Nido PJ, Laussen PC, MayerJE, Lapierre RA, Wilson JM. Mechanical circulatory support in children with cardiac disease. J Thorac Cardiovasc Surg 1999; 117: 529–542.
Wilson JM, Bower LK, Fackler, JC, Beals DA, Berhus BO, Kevy SB. Aminocaproic acid decreases the incidence of intracranial hemorrhage and other hemorrhagic complications of ECMO. J Pediatr Surg 1993; 28: 536–541.
Horwitz JR, Cofer BR, Warner BH, Cheu HW, Lally KP. A multicenter trial of 6-aminocaproic acid (Amicar) in the prevention of bleeding in infants on ECMO. J Pediatric Surg 1998; 33: 1610–1613.
Thompson, CA. Don’t give aprotinin again within 12 months, FDA says. American Society of Health System Pharmacists December 15, 2006.
Lexi-comp© 1978–2007; Poison and Toxicology.
Hursting MJ, Dubb J, Verme-Gibboney CN. Argatroban anticoagulation in pediatric patients. A literature analysis. J Pediatr Hematol Oncol 2006; 28: 4–10.
John TE, Jallisey RK. Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia. Pharmacother 2005; 25: 1383–1388.
Israels SJ, Michelson AD. Antiplatelet therapy in children. Thrombosis Research 2006; 118: 75–83.
Macdonald S. Aspirin use to be banned under 16 year olds. BMJ 2002; 325: 988.
Finkelstein Y, Nurmohamed L, Avner M, Benson LM, Koren G. Clopidogrel use in children. J Pediatr 2005; 147: 657–661.
Soman T, Rafay MF, Hune S, Allen A, MacGregor D, deVeber G. The risks and safety of clopidogrel in pediatric arterial ischemic stroke. Stroke 2006; 37: 1120–1122.
Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110: 2747–2771.
Lexi-Comp© 1978–2007; Pediatic Lexi-Drugs.
Dix D, Andrew M, Marzinotto V, Charpentier K, Bridge S, Monagle P, deVeber G, Leaker M, Chan AK, Massicotte MP. The use of low-molecular-weight heparin in pediatric patients: A prospective cohort study. J Pediatr 2000; 136: 439–445.
Schmidt B, Ofosu FA, Mitchell L, Brooker LA, Andrew M. Anticoagulant effects of heparin in neonatal plasma. Pediatr Res 1989; 25: 405–408.
Gershanik J, Boecler B, Ensley H, et al. The gasping syndrome and benzyl alcohol poisoning. N Engl J Med 1982; 307: 1384–1388.
Cobel-Geard RJ, Hassouna HI. Interaction with protamine sulfate with thrombin. Am J Hematol 1983; 14: 227–233.
Lee C, Nechyba C, Gunn VL, Drug doses. Gunn VL, Nechyba C. The Harriet Lane Handbook. Philadelphia; Mosby, 2002.
Reid RW, Zimmerman AA, Laussen PC, Mayer JE, Gorlin JB, Burrows FA. The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery. Anesth Analg 1997; 84: 990–996.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag London Limited
About this chapter
Cite this chapter
Nguyen, PT., Sandy, J.E., Munoz, R. (2008). Anticoagulants, Antithrombotics, and Antiplatelets. In: Munoz, R., Schmitt, C.G., Roth, S.J., da Cruz, E. (eds) Handbook of Pediatric Cardiovascular Drugs. Springer, London. https://doi.org/10.1007/978-1-84628-953-8_11
Download citation
DOI: https://doi.org/10.1007/978-1-84628-953-8_11
Publisher Name: Springer, London
Print ISBN: 978-1-84628-952-1
Online ISBN: 978-1-84628-953-8
eBook Packages: MedicineMedicine (R0)