Among African Americans and Hispanics in the United States, coronary heart disease (CHD) is highly prevalent and is the single most frequent cause of myocardial infarction and death in that population [1]. However, multiple factors contribute to overall poorer care and worse outcomes among African Americans and Hispanics when compared with whites. These factors include difference in disease manifestation, socioeconomic status, access to care, patient perception of the health care system and of providers, attitudes of health care providers toward minority patients, therapeutic modalities and responses to treatment, and patient education.
Although race-specific CHD data are sparse among black and Hispanic persons, rates of death among African Americans are among the highest in the industrialized world. This may be due to the complexities of race as a health factor or to controversies regarding whether health issues should even be considered in terms of race, as race is inextricably linked with socio-economic status in the United States. Nevertheless, current data indicate that there are increasing disparities in cardiovascular health care among African Americans and Hispanics [1–3]. Compared with whites, African Americans are more likely to present with CHD at an earlier age, have higher out-of-hospital coronary death rates, and are more likely to have sudden cardiac death as the initial clinical presentation of CHD. Although the reasons for these differences are not well understood, it is possible that these health consequences are explained by significant heterogeneity in acute coronary syndrome manifestation among African Americans. A high prevalence of certain coronary risk factors, delays in identification and treatment of high-risk individuals, limited access to cardiovascular care, and lack of compliance and trust in the health care system appear to contribute to the burden of CHD among African Americans.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Gillum RF, Mussolino ME, Madans JH. Coronary heart disease incidence and survival in African-American women and men. The NHANES I epidemiologic follow-up study. Ann Intern Med 1997;127:111–118.
Gillum RF. Sudden cardiac death in Hispanic Americans and African Americans. Am J Public Health 1997;87:1461–1466.
Traven ND, Kuller LH, Ives DG, et al. Coronary heart disease mortality and sudden death among the 35–44 year age group in Allegheny County, Pennsylvania. Ann Epidemiol 1996;6:130–136.
Rowland ML, Fulwood R. Coronary heart disease risk factor trends in blacks between the First and Second National Health and Nutrition Examination Surveys, United States, 1971–1980. Am Heart J 1984;108:771–779.
Hutchinson RG, Watson RL, Davis CE, et al. Racial differences in risk factors for atherosclerosis. The ARIC study. Angiology 1997;48:279–290.
Liao Y, Cooper RS, McGee DL, et al. The relative effects of left ventricular hypertrophy, coronary artery disease, and ventricular dysfunction on survival among black adults. JAMA 1995;273:1592–1597.
Gavin JR III. Diabetes in minorities:refl ections on the medical dilemma and the healthcare crisis. Trans Am Clin Climatol Assoc 1995;107:213–223.
Kannel WB. Historic perspectives on the relative contributions of diastolic and systolic blood pressure elevation to cardiovascular risk profi le. Am Heart J 1999;138:205–210.
Heyman A, Fields WS, Keating RD. Joint Study of Extracranial Arterial Occlusion VI. Racial differences in hospitalized patients with ischemic stroke. JAMA 1972; 222:285.
Dustan H. Growth factors and racial differences in severity of hypertension and renal diseases. Lancet 1992;339:1339–1340.
Whittle JC, Whelton PK, Seidler AJ, et al. Does racial variation in risk factors explain black-white differences in the incidence of hypertensive end-stage renal disease? Arch Intern Med 1991;151:1359–1364.
McCord C, Freeman HB. Excess mortality in Harlem. N Engl J Med 1990;322:173–177.
U.S. Department of Health and Human Services. Report of the Working Group on Research in Coronary Heart Disease in Blacks. Bethesda, MD:U.S. Public Health Service, National Institutes of Health; 1994.
Gillum RF, Grant CT. Coronary heart disease in black populations. II. Risk factors. Am Heart J 1982;104:852–864.
Vital Statistics of the United States, 1973, Vol. II. Mortality, Part A. Washington, DC:U.S. Department of Health, Education and Welfare, Public Health Service, National Center for Health Statistics; 1977.
Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographi-cally determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–1566.
Thomas J, Thomas DJ, Pearson T, et al. Cardiovascular disease in African-American and white physicians:the Meharry Cohort and Meharry-Hopkins Cohort Studies. J Health Care Poor Underserved 1997;8:270–283.
Lorber R, Gidding SS, Daviglus ML, et al. Infl uence of systolic blood pressure and body mass index on left ventricular structure in healthy African-Americans and white young adults:the CARDIA study. J Am Coll Cardiol 2003;41:955–960.
Chaturvedi N, Athanassopoulos G, McKeigue PM, et al. Echocardiographic measures of left ventricular structure and their relation with rest and ambulatory blood pressure in blacks and whites in the United Kingdom. J Am Coll Cardiol 1994;24:1499–1505.
Gottdiener JS, Reda DJ, Materson BJ, et al. Importance of obesity, race and age to the cardiac structural and functional effects of hypertension. J Am Coll Cardiol 1994;24:1492–1498.
Gardin JM, Wagenknecht LE, Anton-Culver H, et al. Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women. The CARDIA Study. Circulation 1995;92:380–387.
Koren MJ, Mensah GA, Blake J, et al. Comparison of left ventricular mass and geometry in black and white patients with essential hypertension. Am J Hypertens 1993; 6:815–823.
Lee DK, Marantz PR, Devereux RB, et al. Left ventricular hypertrophy in black and white hypertensives. Standard electrocardiographic criteria overestimate racial differences in prevalence. JAMA 1992;267:3294–3299.
Wilson PW. Established risk factors and coronary artery disease:the Framingham study. Am J Hypertens 1994;7(7 Pt 2):7S–12S.
Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 1990;322:882–889.
Banerji MA, Lebowitz J, Chaiken RL, et al. Relationships of visceral adipose tissue and glucose disposal in independent of sex in black NIDDM subjects. Am J Physiol 1997;273:E425–432.
Kumanyika S. Searching for the association of obesity with coronary artery disease [editorial]. Obes Res 1995;3:273–275.
Svec F, Rivera M, Huth M. Correlation of waist to hips ratio to the prevalence of diabetes and hypertension in black females. J Natl Med Assoc 1990;82:257–261.
Clark LT, Karve MM, Rones KT, et al. Obesity, distribution of body fat and coronary artery disease in black women. Am J Cardiol 1994;73:895–896.
Kannel WB, Wilson PW. An update on coronary risk factors. Med Clin North Am 1995;79:951–971.
Harris MI, Flegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults. The Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 1998;21:518–524.
Carter JS, Pugh JA, Monterrosa A. Non-insulin-dependent diabetes mellitus in minorities in the United States. Ann Intern Med 1996;125:221–232.
Brancati FL, Kao WHL, Folsom AR, et al. Incident type 2 diabetes mellitus in African American and white adults. The Atherosclerosis Risk in Communities study. JAMA 2000;283:2253–2259.
Taylor HA, Mickel MC, Chaitman BR, et al. Long-term survival of African Americans in the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 1997;29:358–364.
Fiore MC, Novotny TE, Pierce JP, et al. Trends in cigarette smoking in the United States. The changing infl uence of gender and race. JAMA 1989;261:49–55.
American Heart Association. Heart Disease and Stroke Statistical Update:2004 Update. Dallas, TX:American Heart Association; 2003.
Sonel AF, Good CB, Mulgund J, et al. CRUSADE investigators. Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes:insights from CRUSADE (Can Rapid Risk Stratifi cation of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?) Circulation 1994;90:1613–1623.
Lenfant C. Report of the NHLBI Working Group on Research in Coronary Heart Disease in Blacks. Circulation 1994;90:1613–1623.
Xie X, Liu K, Stamler J, et al. Ethnic differences in electrocardiographic left ventricular hypertrophy in young and middle-aged employed American men. Am J Cardiol 1994;73:564–567.
Neaton JD, Kuller LH, Wentworth D, et al. Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for fi ve years. Am Heart J 1984; 108:759–769.
Tyroler HA, Knowles MG, Wing SB, et al. Ischemic heart disease risk factors and twenty-year mortality in middle-age Evans County black males. Am Heart J 1984; 108:738–746.
Johnson JL, Heineman EF, Heiss G, et al. Cardiovascular disease risk factors and mortality among black women and white women aged 40–64 years in Evans County, Georgia. Am J Epidemiol 1986;123:209–220.
American Heart Association. 1998 Heart and Stroke Statistical Update. Dallas, TX:American Heart Association; 1998.
Haffner SM, D'Agostino R Jr, Goff D, et al. LDL size in African Americans, Hispanics, and non-Hispanic whites the Insulin Resistance Atherosclerosis Study. Arterioscler Thromb Vasc Biol 1999;19:2234–2240.
Sorrentino MJ, Vielhauer C, Eisenbart JD, et al. Plasma lipoprotein (a) protein concentration and coronary artery disease in black patients compared with white patients. Am J Med 1992;93:658–662.
Moliterno DJ, Jokinen EV, Miserez AR, et al. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arterioscler Thromb Vasc Biol 1995;15:850–855.
Ferdinand KC. Coronary Artery disease in minority racial and ethnic groups in the United States. A symposium:the interplay of dyslipidemia and infl ammation:reducing cardiovascular risk in diverse patient populations. Am J Cardiol 2006:97(2), suppl. 1:12–19
Anand SS, Razak F, Yi Q, et al. C-reactive protein as a screening test for cardiovascular risk in a multiethnic population, Arterioscler Thromb Vasc Biol 2004;24:1509–1515.
Albert MA, Glynn RJ, Buring J, et al. C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am J Cardiol 2004;93:1238–1242.
Cardillo C, Kilcoyne CM, Cannon RO, et al. Attenuation of cyclic nucleotide-mediated smooth muscle relaxation in blacks as a cause of racial differences in vasodilator function. Circulation 1999;99:90–95.
Simmons BE, Castaner A, Campo A, et al. Coronary artery disease in blacks of lower socioeconomic status:angiographic fi ndings from the Cook County Hospital Heart Disease Registry. Am Heart J 1988;116:90–97.
Houghton JL, Smith VE, Strogatz DS, et al. Effect of African-American race and hypertensive left ventricular hypertrophy on coronary vascular reactivity and endo-thelial function. Hypertension 1997;29:706–714.
ALLHAT Offi cers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic the Antihyper-tensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981–2997.
Jawa A, Nachimuthu S, Pendergrass M, et al. Impaired vascular reactivity in African-American patients with type 2 diabetes mellitus and microalbuminuria or protein-uria despite angiotensin-converting enzyme inhibitor therapy. J Clin Endocrinol Metab 2006;91(1):31–35.
Szczeklik A, Dischinger P, Kueppers F, et al. Blood fi brinolytic activity, social class and habitual physical activity. II. A study of black and white men in southern Georgia. J Chron Dis 1980;33:291–299.
Barr RD, Ouna N, Kendall AG. The blood coagulation and fi brinolytic enzyme systems in healthy adult Africans and Europeans:a comparative study. Scot Med J 1973;18:93–97.
Folsom AR, Qamhieh HT, Flack JM, et al. Plasma fi brinogen:levels and correlates in young adults. Am J Epidemiol 1993;138:1023–1036.
Folsom AR, Wu KK, Conlan MG, et al. Distributions of hemostatic variables in blacks and whites:population reference values from the Atherosclerosis Risk in Communities (ARIC) Study. Ethnicity Dis 1992;2:35–46.
Sane DC, Stump DC, Topol EJ, et al. Racial differences in responses to fi brino-lytic therapy with recombinant tissue-type plasminogen activator. Increased fi brin(ogen)olysis in blacks. Circulation 1991;83:170–175.
Taylor HA, Chaitman BR, Rogers WJ, et al. Race and prognosis after myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) phase II trial. Circulation 1993;88:1484–1494.
The GUSTO Investigators. An international randomized trial comparing four fi brinolytic strategies for acute myocardial infarction. N Engl J Med 1993;329:673–682.
The GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med 1993;329:1615–1622.
Asher CR, Stebbins AL, Maynard CL, et al. Long-term survival differences between African Americans and caucasians following myocardial infarction:one-year follow-up from the GUSTO-I trial [abstract]. Circulation 1996;94:I-196.
Moliterno DM, Asher CR, Califf RM, et al. Less myocardial but more cerebral isch-emic events in African Americans than Caucasians with acute coronary syndromes:results from the GUSTO-II [abstract]. J Am Coll Cardiol 1997;29:131A.
Rowland ML, Fulwood R. Coronary heart disease risk factor trends in blacks between the First and Second National Health and Nutrition Examination Surveys, United States, 1971–1980. Am Heart J 1984;108:771–779.
Ghali JK, Cooper RS, Kowatly I, et al. Delay between onset of chest pain and arrival to the coronary care unit among minority and disadvantaged patients. J Natl Med Assoc 1993;85:180–184.
Raczynksi JM, Taylor H, Cutter G, et al. Diagnoses, symptoms, and attribution of symptoms among black and white inpatients admitted for coronary heart disease. Am J Public Health 1994;84:951–995.
Clark LT, Ferdinand KC, Flack JM, et al.. Coronary Heart Disease in African Americans. Heart Dis 2001;3(2):97–108.
Maynard C, Fisher LD, Passamani ER, et al. Blacks in the Coronary Artery Surgery Study:risk factors and coronary artery disease. Circulation 1986;74:64–71.
Freedman DS, Gruchow HW, Manley JC, et al. Black/white differences in risk factors for arteriographically documented coronary artery disease in men. Am J Cardiol 1988;62:214–219.
Diver DJ, Bier JD, Ferreira PE, et al., for the TIMI-IIIA Investigators. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA trial). Am J Cardiol 1994;74:531–537.
Strong JP, Malcom GT, Oalmann MC, et al. The PDAY study:natural history, risk factors, and pathobiology. Pathobiological Determinants of Atherosclerosis in Youth. Ann NY Acad Sci 1997;811:226–235.
Nakamura Y, Moss AJ, Brown MW, et al. Ethnicity and long-term outcome after an acute coronary event. Multicenter Myocardial Ischemia Research Group. Am Heart J 1999;138:500–506.
Haywood LJ. Coronary heart disease mortality/morbidity and risk in blacks. I:Clinical manifestations and diagnostic criteria:the experience with the Beta Blocker Heart Attack Trial. Am Heart J 1984;108:787–793.
Borzak S, Joseph C, Havstad S, et al. Lower fi brinolytic use for African Americans with myocardial infarction:an infl uence of clinical presentation? Am Heart J 1999;137:338–345.
Maynard C, Litwin PE, Martin JS, et al. Characteristics of black patients admitted to coronary care units in metropolitan Seattle:results from the Myocar-dial Infarction Triage and Intervention Registry (MITI). Am J Cardiol 1991;67:18–23.
Traven ND, Kuller LH, Ives DG, et al. Coronary heart disease mortality and sudden death among the 35–44-year age group in Allegheny County, Pennsylvania. Ann Epidemiol 1996;6:130–136.
Becker LB, Han BH, Meyer PM, et al., Racial differences in the incidence of cardiac arrest and subsequent survival. N Engl J Med 1993;329:600–606.
Gillum RF. Sudden coronary death in the United States:1980–1985. Circulation 1989;79:756–765.
Chen J, Rathore SS, Radford MJ, et al. Racial differences in the use of cardiac cathe-terization after acute myocardial infarction. N Engl J Med 2001;344:1443–1449.
Hannan EL, van Ryn M, Burke J, et al. Access to coronary artery bypass surgery by race/ethnicity and gender among patients who are appropriate for surgery. Med Care 1999;37:68–77.
Vaccarino V, Rathore SS, Wenger NK, et al. Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. N Engl J Med 2005;353:671–682.
Arnold AL, Milner KA, Vaccarino V. Sex and race differences in electrocardiogram use (the National Hospital Ambulatory Medical Care Survey). Am J Cardiol 2001; 88:1037–1040.
LaVeist TA, Arthur M, Morgan A, et al, The cardiac access longitudinal study. A study of access to invasive cardiology among African American and white patients. J Am Coll Cardiol 2003;41:1159–1166.
Blustein, Jan, Weitzman, Beth C. Access to hospitals with high-technology cardiac services:How is race important? American Journal of Public Health. Washington 1995;85(3):345–351.
Bradley E, Herrin J, Wang Y, et al. Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction. JAMA 2004;292:1563–1572.
Barnato AE, Lucas FL, Staiger D, et al. Hospital-level racial disparities in acute myocardial infarction treatment and outcomes. Med Care 2005;43:308–319.
Bach PB, Pham HH, Schrag D, et al. Primary care physicians who treat blacks and whites. N Engl J Med 2004;351:575–584.
Rathore SS, Berger AK, Weinfurt KP, et al. Race, sex, poverty, and the medical treatment of acute myocardial infarction in the elderly. Circulation 2000;102:642–648.
Rao SV, Schulman KA, Curtis LH, et al. Socioeconomic status and outcome following acute myocardial infarction in elderly patients. Arch Intern Med 2004;164:1128–1133.
Whittle J, Conigliaro J, Good CB, et al. Racial differences in the use of invasive cardiovascular procedures in the Department of Veterans Affairs medical system. N Engl J Med 1993;329:621–627.
Whittle J, Conigliaro J, Good CB, et al. Do patient preferences contribute to racial differences in cardiovascular procedure use? J Gen Intern Med 1997;12:267–273.
Schecter AD, Goldschmidt-Clermont PJ, McKee G, et al. Infl uence of gender, race and education on patient preferences and receipt of cardiac catheterizations among coronary care unit patients. Am J Cardiol 1996;78:996–1001.
Shenolikar RA, Balkrishnan R, Camacho FT, et al. Race and medication adherence in Medicaid enrollees with type-2 diabetes. J Natl Med Assoc 2006;98(7):1071–1077.
Boulware LE, Cooper LA, Ratner LE, et al. Race and trust in the health care system. Public Health Rep 2003;118(4):358–365.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag London Limited
About this chapter
Cite this chapter
Sirak, T., Chiadika, S., Daka, M., Simon, C. (2008). Acute Coronary Syndrome in African Americans and Hispanic Americans. In: Hong, M.K., Herzog, E. (eds) Acute Coronary Syndrome. Springer, London. https://doi.org/10.1007/978-1-84628-869-2_21
Download citation
DOI: https://doi.org/10.1007/978-1-84628-869-2_21
Publisher Name: Springer, London
Print ISBN: 978-1-84628-868-5
Online ISBN: 978-1-84628-869-2
eBook Packages: MedicineMedicine (R0)