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References
Aderjan R, Mattern R. Validity of digoxin concentrations in blood determined post mortem (author’s transl). Z Rechtsmed 1980; 86(1): 13–20.
Koren G, Parker R. Interpretation of excessive serum concentrations of digoxin in children. Am J Cardiol 1985; 55(9): 1210–1214.
Barnhart FE, Bonnell HJ, Rossum KM. Post-mortem drug redistribution. Forensic Sci Rev 2001; 13: 101–128.
Prouty RW, Anderson WH. The forensic science implications of site and temporal influences on postmortem blood–drug concentrations. J Forensic Sci 1990; 35(2): 243–270.
Pounder DJ, Jones GR. Postmortem drug redistribution—a toxicological nightmare. Forensic Sci Int 1990; 45: 253–263.
Basic Clinical Pharmacokinetics 4th edn. by Michael E. Winter. Lippincott, Williams & Wilkins, 2003.
Pounder DJ, Smith DR. Postmortem diffusion of alcohol from the stomach. Am J Forensic Med Pathol 1995; 16(2): 89–96.
Takayasu T, Ohshima T, Tanaka N, et al. Experimental studies on postmortem diffusion of ethanol-d6 using rats. Forensic Sci Int 1995.
Pounder DJ, Fuke C, Cox DE, Smith D, Kuroda N. Postmortem diffusion of drugs from gastric residue: an experimental study. Am J Forensic Med Pathol 1996; 17(1): 1–7.
Fuke C, Berry CL, Pounder DJ. Postmortem diffusion of ingested and aspirated paint thinner. Forensic Sci Int 1996; 78(3): 199–207.
Pounder DJ, Adams E, Fuke C, Langford AM. Site to site variability of postmortem drug concentrations in liver and lung. J Forensic Sci 1996; 41(6): 927–932.
Hilberg T, Rogde S, Morland J. Postmortem drug redistribution—human cases related to results in experimental animals. J Forensic Sci 1999; 44(1): 3–9.
Takayasu T, Ohshima T, Tanaka N, et al. Experimental studies on postmortem diffusion of ethanol-d6 using rats. Forensic Sci Int 1995; 76(3): 179–188.
Hilberg T, Morland J, Bjorneboe A. Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution. Forensic Sci Int 1994; 64(1): 47–55.
Skopp G, Lutz R, Potsch L, et al. An in vitro experiment for postmortem vascular permeation. The passage of morphine and morphine glucuronides across a vascular wall. J Forensic Sci 1997; 42(3): 486–491.
Moriya F, Hashimoto Y. Postmortem diffusion of drugs from the bladder into femoral venous blood. Forensic Sci Int 2001; 123(2–3): 248–253.
Koren G, MacLeod SM. Postmortem redistribution of digoxin in rats. J Forensic Sci 1985; 30(1): 92–96.
Sawyer WR, Forney RB. Postmortem disposition of morphine in rats. Forensic Sci Int 1988; 38: 259–273.
Hilberg T, Bugge A, Beylich KM, Ingum J, Bjorneboe A, Morland J. An animal model of postmortem amitriptyline redistribution. J Forensic Sci 1993; 38(1): 81–90.
Shiota H, Nakashima M, Terazono H, et al. Postmortem changes in tissue concentrations of triazolam and diazepam in rats. Legal Med 2004; 6(4): 224.
Castaing N, Titier K, Canal-Raffin M, Moore N, Molimard M. Postmortem redistribution of two antipsychotic drugs, haloperidol and thioridazine, in the rat. J Anal Toxicol 2006; 30: 419–425.
Hilberg T, Bugge A, Beylich KM, Mørland J, Bjorneboe A. Diffusion as a mechanism of postmortem drug redistribution: an experimental study in rats. Int J Legal Med 1992; 105: 87–91.
Moriya F, Hashimoto Y. Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem. J Forensic Sci 1999; 44(1): 10–16.
Moriya F, Hashimoto Y. Postmortem diffusion of tracheal lidocaine into heart blood following intubation for cardiopulmonary resuscitation. J Forensic Sci 1997; 42: 296–299.
De Letter EA, Belpaire FM, Clauwaert KM, Lambert WE, Van Bocxlaer JF, Piette MH. Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in the rabbit. Part II: post-mortem infusion in trachea or stomach. Int J Legal Med 2002; 116(4): 225–232.
Kugelberg FC, Kingback M, Carlsson B, Druid H. Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats. J Anal Toxicol 2005; 29(4): 223–228.
Pounder DJ, Hartley AK, Watmough PJ. Postmortem redistribution and degradation of dothiepin. Human case studies and an animal model. Am J Forensic Med Pathol 1994; 15: 231–235.
Kunsman GW, Rodriguez R, Rodriguez P. Fluvoxamine distribution in postmortem cases. Am J Forensic Med Pathol 1999; 20(1): 78–83.
Rodda KE, Drummer OH. The redistribution of selected psychiatric drugs in post-mortem cases. Forensic Sci Int 2006; 164: 235–239.
Jenkins AJ, Gubanich K. Disposition of citalopram in biological specimens from postmortem cases. J Forensic Sci 2002; 47: 159–164.
Anderson DT, Fritz KL, Muto JJ. Distribution of mirtazapine (Remeron) in thirteen postmortem cases. J Anal Toxicol 1999; 23(6): 544–548.
Anderson DT, Fritz KL. Quetiapine (Seroquel) concentrations in seven postmortem cases. J Anal Toxicol 2000; 24(4): 300–304.
Flanagan RJ, Amin A, Seinen W. Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa). Forensic Sci Int 2003; 132(1): 9.
Horak EL, Jenkins AJ. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J Forensic Sci 2005; 50(3): 679–681.
Merrick TC, Felo JA, Jenkins AJ. Tissue distribution of olanzapine in a postmortem case. Am J Forensic Med Pathol 2001; 22(3): 270–274.
Robertson MR, Drummer OH. Postmortem distribution and redistribution of nitrobenzodiazepines in man. J Forensic Sci 1998; 43(1): 9–13.
Gock SB, Wong SH, Nuwayhid N, et al. Acute zolpidem overdose—report of two cases. J Anal Toxicol 1999; 23: 559–562.
Meeker JE, Som CW, Macapagal EC, Benson PA. Zolpidem tissue concentrations in a multiple drug related death involving Ambien. J Anal Toxicol 1995; 19: 531–534.
Logan BK, Smirnow D, Gullberg RG. Lack of predictable site-dependent differences and time-dependent changes in postmortem concentrations of cocaine, benzoylecgonine, and cocaethylene in humans. J Anal Toxicol 1997; 21(1): 23–31.
Hearn WL, Keran EE, Wei HA, Hime G. Site-dependent postmortem changes in blood cocaine concentrations. J Forensic Sci 1991; 36(3): 673–684.
Elliott S, Lowe P, Symonds A. The possible influence of micro-organisms and putrefaction in the production of GHB in post-mortem biological fluid. Forensic Sci Int 2004; 139(2–3): 183–190.
Moriya F, Hashimoto Y. Endogenous gamma-hydroxybutyric acid levels in postmortem blood. Legal Med (Tokyo) 2004; 6(1): 47–51.
Berankova K, Mutnanska K, Balikova M. Gamma-hydroxybutyric acid stability and formation in blood and urine. Forensic Sci Int 2006; 161(2–3): 158–162.
Elliott SP. Gamma hydroxybutyric acid (GHB) concentrations in humans and factors affecting endogenous production. Forensic Sci Int 2003; 133(1–2): 9–16.
Degenhardt L, Copeland J, Dillon P. Recent trends in the use of “club drugs”: an Australian review. Subst Use Misuse 2005; 40(9–10): 1241–1256.
Kelly BC, Parsons JT, Wells BE. Prevalence and predictors of club drug use among club-going young adults in New York city. J Urban Health 2006; 83(5): 884–895.
Fang YX, Wang YB, Shi J, Liu ZM, Lu L. Recent trends in drug abuse in China. Acta Pharmacol Sin 2006; 27(2): 140–144.
Lalonde BR, Wallage HR. Postmortem blood ketamine distribution in two fatalities. J Anal Toxicol 2004; 28(1): 71–74.
Koren G, Klein J. Postmortem redistribution of morphine in rats. Ther Drug Monit 1992; 14(6): 461–463.
Logan BK, Snirnow D. Postmortem distribution and redistribution of morphine in man. J Forensic Sci 1996; 41: 37–46.
Gerostamoulos J, Drummer OH. Postmortem redistribution of morphine and its metabolites. J Forensic Sci 2000; 45(4): 843–845.
Crandall CS, Kerrigan S, Blau RL, Lavalley J, Zumwalt R, McKinney PE. The influence of site of collection on postmortem morphine concentrations in heroin overdose victims. J Forensic Sci 2006; 51(2): 413–420.
Levine B, Wu SC, Dixon A, Smialek JE. Site dependence of postmortem blood methadone concentrations. Am J Forensic Med Pathol 1995; 16(2): 97–100.
Caplehorn JR, Drummer OH. Methadone dose and post-mortem blood concentration. Drug Alcohol Rev 2002; 21(4): 329–333.
Cook DS, Braithwaite RA, Hale KA. Estimating antemortem drug concentrations from postmortem blood samples: the influence of postmortem redistribution. J Clin Pathol 2000; 53(4): 282–285.
Elliott SP. MDMA and MDA concentrations in antemortem and postmortem specimens in fatalities following hospital admission. J Anal Toxicol 2005; 29(5): 296–300.
De Letter EA, Bouche MP, Van Bocxlaer JF, Lambert WE, Piette MH. Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities. Forensic Sci Int 2004; 141(2–3): 85–90.
Moriya F, Hashimoto Y. Redistribution of methamphetamine in the early postmortem period. J Anal Toxicol 2000; 24(2): 153–155.
Chu M. Studies on the Toxicology of Cananbis [PhD(med)]. Melbourne: Monash University, 2002.
Hilberg T, Ripel A, Slordal L, Bjorneboe A, Morland J. The extent of postmortem drug redistribution in a rat model. J Forensic Sci 1999; 44(5): 956–962.
Gomez HF, Mcinney P, Phillips S, Roberts DV, Brent J, Watson WA. Postmortem acetaminophen pharmacokinetics: an experimental study of site and time-dependent changes. J Forensic Sci 1995; 40: 980–982.
Moriya F, Hashimoto Y. Distribution of free and conjugated morphine in body fluids and tissues in a fatal heroin overdose: is conjugated morphine stable in postmortem specimens? J Forensic Sci 1997; 42(4): 736–740.
Carroll FT, Marraccini JV, Lewis S, Wright W. Morphine-3-D glucuronide stability in postmortem specimens exposed to bacterial enzymatic hydrolysis. Am J Forensic Med Pathol 2000; 21: 323–329.
Skopp G, Potsch L, Klingmann A, Mattern R. Stability of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in fresh blood and plasma and postmortem blood samples. J Anal Toxicol 2001; 25(1): 2–7.
Pounder DJ. The case of Dr. Shipman. Am J Forensic Med Pathol 2003; 24: 219–226.
Robertson MD, Drummer OH. Stability of nitrobenzodiazepines in postmortem blood. J Forensic Sci 1998; 43(1): 5–8.
Moriya F, Hashimoto Y. Postmortem stability of cocaine and cocaethylene in blood and tissues of humans and rabbits. J Forensic Sci 1996; 41(4): 612–616.
Routledge PA, Kitchell BB, Bjornsson TD, Skinner T, Linnoila M, Shand DG. Diazepam and N-desmethyldiazepam redistribution after heparin. Clin Pharmacol Ther 1980; 28: 528–532.
Batziris HP, McIntyre IM, Drummer OH. The effect of sulfur-metabolising bacteria on sulfur-containing psychotropic drugs. Int Biodeterior Biodegradation 1999; 44(2–3): 111–116.
Skopp G, Lutz R, Ganssmann B, Mattern R, Aderjan R. Postmortem distribution pattern of morphine and morphine glucuronides in heroin overdose. Int J Legal Med 1996; 109(3): 118–124.
Skopp G. Preanalytic aspects in postmortem toxicology. Forensic Sci Int 2004; 142(2–3): 75–100.
Levisky JA, Bowerman DL, Jenkins WW, Johnson DG, Karch SB. Drugs in postmortem adipose tissues: evidence of antemortem deposition. Forensic Sci Int 2001; 121(3): 157–160.
Moor MJ, Steiner SH, Jachertz G, Bickel MH. Adipose tissue distribution and chemical structure of basic lipophilic drugs: desipamine, N-acetyldesipramine, and haloperidol. Pharmacol Toxicol 1992; 70: 121–124.
Bickel MH, Graber BE, Moor M. Distribution of chlorpromazine and imipramine in adipose and other tissues of rats. Life Sci 1983; 33(20): 2025–2031.
Minder S, Daniel WA, Clausen J, Bickel MH. Adipose tissue storage of drugs as a function of binding competition. In-vitro studies with distribution dialysis. J Pharm Pharmacol 1994; 46(4): 313–315.
Coe JI. Postmortem chemistry update. Emphasis on forensic application. Am J Forensic Med Pathol 1993; 14(2): 91–117.
Kudo K, Nagata T, Kimura K, Imamura T, Urakawa N. Postmortem changes of triazolam concentrations in body tissues. Nihon Hoigaku Zasshi 1992; 46(5): 293–296.
Quatrehomme G, Bourret F, Xhioua M, Lapalus P, Ollier A. Post mortem kinetics of secobarbital. Forensic Sci Int 1990; 44: 117–123.
Quatrehomme G, Bourret F, Liao Z, Ollier A. An experimental methodology for the study of postmortem changes in toxic concentrations of drug using secobarbital as an example. J Forensic Sci 1994; 39: 1300–1304.
Moriya F, Hashimoto Y. The effect of postmortem interval on the concentrations of cocaine and cocaethylene in blood and tissues: an experiment using rats. J Forensic Sci 1996; 41(1): 129–133.
Pohland RC, Bernhard NR. Postmortem serum and tissue redistribution of fluoxetine and norfluoxetine in dogs following oral administration of fluoxetine hydrochloride (Prozac). J Forensic Sci 1997; 42: 812–816.
Hilberg T, Ripel A, Smith AJ, Slordal L, Morland J, Bjorneboe A. Postmortem amitriptyline pharmacokinetics in pigs after oral and intravenous routes of administration. J Forensic Sci 1998; 43(2): 380–387.
Rogde S, Hilberg T, Teige B. Fatal combined intoxication with new antidepressants. Human cases and an experimental study of postmortem moclobemide redistribution. Forensic Sci Int 1999; 100(1–2): 109–116.
Flanagan RJ, Amin A, Seinen W. Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa). Forensic Sci Int 2003; 132(1): 9–17.
Kuhlman JJ, Jr., Mayes RW, Levine B, Jones R, Wagner GN, Smith ML. Chloroquine distribution in postmortem cases. J Forensic Sci 1991; 36(5): 1572–1579.
Koren G, Beatie D, Soldin S, Einerson TR, MacLeod S. Interpretation of elevated postmortem serum concentrations of digoxin in infants and children. Arch Pathol Lab Med 1989; 113(7): 758–761.
Kintz P, Villain M, Pelissier AL, Cirimele V, Leonetti G. Unusually high concentrations in a fatal GHB case. J Anal Toxicol 2005; 29(6): 582–585.
Garcia-Repetto R, Moreno E, Soriano T, Jurado C, Gimenez MP, Menendez M. Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose. Forensic Sci Int 2003; 135(2): 110.
Barnhart FE, Fogacci JR, Reed DW. Methamphetamine—a study of postmortem redistribution. J Anal Toxicol 1999; 23: 69–70.
Logan BK, Smirnow D. Postmortem distribution and redistribution of morphine in man. J Forensic Sci 1996; 41(2): 221–229.
Gerostamoulos J, Drummer OH. Postmortem redistribution of morphine and its metabolites. J Forensic Sci 2000; 45(4): 843–845.
Wise S, Jenkins AJ. Disposition of quetiapine in biological specimens from postmortem cases. J Forensic Sci 2005; 50: 209–214.
Flammia DD, Valouch T, Venuti S. Tissue distribution of quetiapine in 20 cases in Virginia. J Anal Toxicol 2006; 30(4): 287–292.
Jaffe P. The Distribution and Redistribution of Four Serotonin Reuptake Inhibitors in Postmortem Specimens [B Sc (Honours)]. Melbourne: Monash University, 1997.
Pounder DJ, Davies JI. Zopiclone poisoning: tissue distribution and potential for postmortem diffusion. Forensic Sci Int 1994; 65(3): 177–183.
Drummer OH. Clarke’s Isolation and Identification of Drugs, 3rd edn. London: The Pharmaceutical Press, 2004.
Drummer OH, Odell M. The Forensic Pharmacology of Drugs of Abuse. London: Arnold, 2001.
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Drummer, O.H. (2008). Postmortem Toxicological Redistribution. In: Rutty, G.N. (eds) Essentials of Autopsy Practice. Springer, London. https://doi.org/10.1007/978-1-84628-835-7_1
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