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Glucose Disturbance and Acute Heart Failure Syndrome

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Acute Heart Failure

Abstract

Acute heart failure syndrome (AHFS) is a common clinical syndrome in the intensive care setting. It can be caused by primarily cardiac pathology such as acute coronary syndromes (ACSs), acute myocarditis, acute endocarditis with severe valvular insufficiency, and several other cardiac diseases. In the cardiac surgical intensive care unit, acute heart failure, eventually leading to cardiogenic shock, is a well-described problem, often referred to as postcardiotomy heart failure. Besides these single organ failure syndromes, acute or chronic heart failure is often part of the multiorgan failure syndrome and accompanies sepsis, septic shock, and the systemic inflammatory response syndrome. Each of these clinical entities has its proper causal and supportive therapy.

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References

  1. Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001;32:2426–32.

    Article  CAS  PubMed  Google Scholar 

  2. Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000;355:773–8.

    Article  CAS  PubMed  Google Scholar 

  3. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359–67.

    Article  PubMed  Google Scholar 

  4. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy of medical intensive care patients. N Engl J Med 2006;354:449–61.

    Article  PubMed  Google Scholar 

  5. Sack MN, Yellon DM. Insulin therapy as an adjunct to reperfusion after acute coronary ischemia. A proposed direct myocardial cell survival effect independent of metabolic modulation. J Am Coll Cardiol 2003;41:1404–7.

    Article  CAS  PubMed  Google Scholar 

  6. Sodi-Pallares D, Testelli MR, Fishleder BL, et al. Effects of an intravenous infusion of a potassiumglucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 1962;9:166–81.

    Article  CAS  PubMed  Google Scholar 

  7. Fath-Ordoubadi F, Beat KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction. An overview of randomized placebocontrolled trials. Circulation 1997;96:1152–56.

    CAS  PubMed  Google Scholar 

  8. Gnaim CI, McGuire DK. Glucose-insulin-potassium therapy for acute myocardial infarction: What goes around comes around. Am Heart J 2004;148:924–30.

    Article  CAS  PubMed  Google Scholar 

  9. The CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction. The CREATE-ECLA randomized controlled trial. JAMA 2005;293:437–46.

    Article  Google Scholar 

  10. Malmberg K, Rydén L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 2005;26:650–61.

    Article  CAS  PubMed  Google Scholar 

  11. Van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003;31:359–66.

    Article  PubMed  Google Scholar 

  12. Kersten JR, Schmeling TJ, Orth KG, et al. Acute hyperglycemia abolishes ischemic preconditioning in vivo. Am J Physiol Heart Circ Physiol 1998;275:H721–5.

    CAS  Google Scholar 

  13. Kersten JR, Toller WG, Gross ER, et al. Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality. Am J Physiol Heart Circ Physiol 2000;278:H1218–24.

    CAS  PubMed  Google Scholar 

  14. Kersten JR, Montgomery MW, Ghassemi T, et al. Diabetes and hyperglycemia impair activation of mitochondrial KATP channels. Am J Physiol Heart Circ Physiol 2001;280:H1744–50.

    CAS  PubMed  Google Scholar 

  15. Ceriello A, Quagliaro L, D’Amico M, et al. Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat. Diabetes 2002;51:1076–82.

    Article  CAS  PubMed  Google Scholar 

  16. Jonassen AK, Brar BK, Mjös OD, et al. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible antiapoptotic mechanism. J Mol Cell Cardiol 2 2000;32:757–64.

    Article  CAS  Google Scholar 

  17. Jonassen AK, Sack MN, Mjös OD, et al. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2 2001;89:1191–8.

    Article  CAS  Google Scholar 

  18. Gao F, Gao E, Yue T-L, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion. The roles of P13-kinase, Akt and endothelial Nitric Oxide Synthase phosphorylation. Circulation 2002;105:1497–1502.

    Article  CAS  PubMed  Google Scholar 

  19. LaDisa JF, Krolikowski JG, Pagel PS, et al. Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia. Am J Physiol Heart Circ Physiol 2004;287:H601–7.

    Article  CAS  PubMed  Google Scholar 

  20. Clement S, Braithwaite SS, Magee MF, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care 2004;27:553–91.

    Article  PubMed  Google Scholar 

  21. Malmberg K. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ 1997;314:1512–5.

    CAS  PubMed  Google Scholar 

  22. Bolk J, van der Ploeg T, Cornel JH, et al. Impaired glucose metabolism predicts mortality after a myocardial infarction. Int J Cardiol 2001;79:207–14.

    Article  CAS  PubMed  Google Scholar 

  23. Doenst T, Wijeysundera D, Karkouti K, et al. Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 2005;130:1144–50.

    Article  PubMed  Google Scholar 

  24. Furnary AP, Gao G, Grunkemeier GL, et al. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003;125:1007–21.

    Article  CAS  PubMed  Google Scholar 

  25. Lazar HL, Chipkin SR, Fitzgerald CA, et al. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004;109:1497–1502.

    Article  CAS  PubMed  Google Scholar 

  26. Bothe W, Olschewski M, Beyersdorf F, et al. Glucose-insulin-potassium in cardiac surgery: a meta-analysis. Ann Thorac Surg 2004;78:1650–8.

    Article  PubMed  Google Scholar 

  27. Quinn DW, Pagano D, Bonser RS, et al. Improved myocardial protection during coronary artery surgery with glucose-insulin-potassium: a randomized controlled trial. J Thorac Cardiovasc Surg 2006;131:34–42.

    Article  CAS  PubMed  Google Scholar 

  28. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004;79:992–1000.

    Article  PubMed  Google Scholar 

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Vlasselaers, D., Van den Berghe, G. (2008). Glucose Disturbance and Acute Heart Failure Syndrome. In: Mebazaa, A., Gheorghiade, M., Zannad, F.M., Parrillo, J.E. (eds) Acute Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84628-782-4_71

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  • DOI: https://doi.org/10.1007/978-1-84628-782-4_71

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-781-7

  • Online ISBN: 978-1-84628-782-4

  • eBook Packages: MedicineMedicine (R0)

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