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Cardiac Resynchronization Therapy in Acute and Chronic Heart Failure Syndromes

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Acute Heart Failure

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Abstract

Despite recent advances in drug treatment, congestive heart failure (CHF) remains a major health care issue associated with a poor quality of life and a severe prognosis. In the last decade, cardiac resynchronization therapy (CRT) has been assessed as a new therapy option in patients with severe left ventricular (LV) dysfunction. Hence, CRT has become a challenging and an efficient treatment in patients in New York Heart Association (NYHA) class III or IV with a left ventricular ejection fraction (LVEF) of less than 35%, wide QRS, or echocardiographic ventricular dyssynchrony. 1–6 Recently, CRT has demonstrated a significant reduction in both overall and cardiac mortality and great improvement in various functional parameters.6 It is now a validated treatment for severe CHF patients in NYHA class III or IV despite an optimal medical therapy. This chapter summarizes the history of CRT since preliminary reports have been published, and addresses a challenging question about the usefulness of CRT in unstable overt CHF patients.

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References

  1. Auricchio A, Stellbrink C, Sack S, et al. Pacing Therapies in Congestive Heart Failure (PATH-CHF) Study Group. Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol 2002;39:2026–33.

    Article  PubMed  Google Scholar 

  2. Cazeau S, Leclercq C, Lavergne T, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med 2001;344:873–80.

    Article  CAS  PubMed  Google Scholar 

  3. Abraham WT, Fisher WG, Smith AL, et al. Multi-center InSync Randomized Clinical Evaluation (MIRACLE) Study Group. Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure. Circulation 2003;107:1985–90.

    Article  PubMed  Google Scholar 

  4. Bristow MR, Saxon LA, Boehmer J, et al. Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:2140–50.

    Article  CAS  PubMed  Google Scholar 

  5. Lozano I, Bocchiardo M, Achtelik M, et al. VENTAK CHF/CONTAK CD Investigators Study Group. Impact of biventricular pacing on mortality in a randomized crossover study of patients with heart failure and ventricular arrhythmias. Pacing Clin Electrophysiol 2000;23:1711–2.

    CAS  PubMed  Google Scholar 

  6. Cleland J, Daubert JC, Erdmann E, et al. Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005;352:1539–49.

    Article  CAS  PubMed  Google Scholar 

  7. Iuliano S, Fisher SG, Karasik PE, Fletcher RD, Singh SN. QRS duration and mortality in patients with congestive heart failure. Am Heart J 2002;143:1085–91.

    Article  PubMed  Google Scholar 

  8. Stellbrink C, Auricchio A, Diem B, et al. Potential benefit of biventricular pacing in patients with congestive heart failure and ventricular tachyarrhythmia. Am J Cardiol 1999;83:143D–50D.

    Article  CAS  PubMed  Google Scholar 

  9. Silverman ME, Pressel MD, Brackett JC, Lauria SS, Gold MR, Gottlieb SS. Prognostic value of the signal-averaged electrocardiogram and a prolonged QRS in ischemic and nonischemic cardiomyopathy. Am J Cardiol 1995;75:460–4.

    Article  CAS  PubMed  Google Scholar 

  10. Shamim W, Francis DP, Yousufuddin M, et al. Intraventricular conduction delay: a prognostic marker in chronic heart failure. Int J Cardiol 1999;70:171–8.

    Article  CAS  PubMed  Google Scholar 

  11. Grines CL, Bashore TM, Boudoulas H, et al. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. Circulation 1989;79:845–53.

    CAS  PubMed  Google Scholar 

  12. Nishimura RA, Hayes DL, Holmes DR, et al. Mechanism of hemodynamic improvement by dualchamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study. J Am Coll Cardiol 1995;25:281–8.

    Article  CAS  PubMed  Google Scholar 

  13. Brecker SJD, Xiao HB, Sparrow J, et al. Effects of dual chamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet 1992;340:1308–12.

    Article  CAS  PubMed  Google Scholar 

  14. Leclercq C, Cazeau S, Le Breton H, et al. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol 1998;32:1825–31.

    Article  CAS  PubMed  Google Scholar 

  15. Nelson GS, Berger RD, Fetics BJ, et al. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation 2000;102:3053–9.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiology, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Paul Milliez MD, PhD, Abdeddayem Haggui MD, Fabrice Extramiana MD, PhD & Antoine Leenhardt MD

  2. Medical and Respiratory Intensive Care Unit, Croix Rousse Hospital, Lyon, France

    Olivier Thomas MD

Authors
  1. Paul Milliez MD, PhD
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  2. Abdeddayem Haggui MD
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  3. Fabrice Extramiana MD, PhD
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  4. Olivier Thomas MD
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  5. Antoine Leenhardt MD
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Alexandre Mebazaa MD, PhD (Professor of Medicine) (Professor of Medicine)

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Mihai Gheorghiade MD, FACC (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service) (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service)

  3. Department of Cardiology Centre d’Investigation Clinique (CIC), INSERM U-684, Centre Hospitalier Universitaire, University Henri Poincaré, Nancy, France

    Faiez M. Zannad MD, PhD, FESC (Professor of Medicine) (Professor of Medicine)

  4. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

  5. Cooper Heart Institute, Cooper University Hospital, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

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© 2008 Springer-Verlag London Limited

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Milliez, P., Haggui, A., Extramiana, F., Thomas, O., Leenhardt, A. (2008). Cardiac Resynchronization Therapy in Acute and Chronic Heart Failure Syndromes. In: Mebazaa, A., Gheorghiade, M., Zannad, F.M., Parrillo, J.E. (eds) Acute Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84628-782-4_62

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  • DOI: https://doi.org/10.1007/978-1-84628-782-4_62

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-781-7

  • Online ISBN: 978-1-84628-782-4

  • eBook Packages: MedicineMedicine (R0)

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