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Normal Physiology and Pathophysiology of Left Ventricular Systole

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Acute Heart Failure

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Abstract

Left ventricular (LV) systole is defined as that part of the cardiac cycle wherein active contraction occurs. Contractile performance is a major determinant of overall cardiac function. The final end-systolic pressure and volume are a function of intrinsic cardiac contractility, myocardial energy state, and ventricular-arterial coupling, whereas the developed stroke volume and stroke work are a function of these factors plus end-diastolic volume. Since end-diastolic volume is a primary determinant of systolic function, through the Frank-Starling mechanism, diastolic dysfunction directly alters systolic performance. Diastolic dysfunction is discussed elsewhere in this volume. In this chapter we focus only on systolic events.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Marc A. Simon MD

  2. Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Michael R. Pinsky MD, CM, Dr, hc

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  1. Marc A. Simon MD
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  2. Michael R. Pinsky MD, CM, Dr, hc
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Alexandre Mebazaa MD, PhD (Professor of Medicine) (Professor of Medicine)

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Mihai Gheorghiade MD, FACC (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service) (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service)

  3. Department of Cardiology Centre d’Investigation Clinique (CIC), INSERM U-684, Centre Hospitalier Universitaire, University Henri Poincaré, Nancy, France

    Faiez M. Zannad MD, PhD, FESC (Professor of Medicine) (Professor of Medicine)

  4. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

  5. Cooper Heart Institute, Cooper University Hospital, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

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© 2008 Springer-Verlag London Limited

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Simon, M.A., Pinsky, M.R. (2008). Normal Physiology and Pathophysiology of Left Ventricular Systole. In: Mebazaa, A., Gheorghiade, M., Zannad, F.M., Parrillo, J.E. (eds) Acute Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84628-782-4_6

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  • DOI: https://doi.org/10.1007/978-1-84628-782-4_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-781-7

  • Online ISBN: 978-1-84628-782-4

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