The Alimentary Tract and Exocrine Pancreas

  • Jean W. Keeling

Gastrointestinal abnormality is common in both the fetus and the neonate. Gastrointestinal malformations are diagnosed in fetal life with increasing frequency, enabling delivery in units with appropriate facilities. Gastrointestinal malformations, both isolated and syndromatic, are encountered at necropsy, although only a small proportion are, in themselves, fatal. Malformations and post-natally acquired disease contribute to neonatal morbidity and mortality, comprising most of the specimens received from neonatal surgical units. An understanding of gastrointestinal development, the range of pathological abnormalities, their associations, and their signifi cance makes an important contribution to clinical management of the affected individual and family.


Exocrine Pancreas Esophageal Atresia Duodenal Atresia Intestinal Atresia Infantile Hypertrophic Pyloric Stenosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Aitken J (1963) Exomphalos. Analysis of a 10 year series of 32 cases. Arch Dis Child 38:126–129PubMedCrossRefGoogle Scholar
  2. Almog B, Leibovitch L, Achiron R (2001) Split noto-chord syndrome—prenatal ultrasonographic diagnosis. Prenat Diagn 21:1159–1162PubMedCrossRefGoogle Scholar
  3. Amoury RA, Ashcraft KW, Holder TM (1977) Gastro-schisis complicated by intestinal atresia. Surgery 82:373–381PubMedGoogle Scholar
  4. Andrew A (1971) The origin of intramural ganglia. IV. The origin of enteric ganglia: a critical review and discussion of the present state of the problem. J Anat 108:169–184PubMedGoogle Scholar
  5. Antonioli DA (1997) Colitis in infants and children. In: Dahms BB, Qualman SJ (eds) Perspectives in Pediatric Pathology, vol 20. Karger, Basel, pp. 77–110Google Scholar
  6. Armbrust S, Hoffman R, Jochum F, Neumann LM, Fusch C (2005) Restrictive dermopathy associated with transposition of the great arteries microcolon: a rare neonatal entity with new symptoms. Arch Der-matol 141:611–613Google Scholar
  7. Avery ME, Fletcher BD, Williams RG (1981) The Lung and Its Disorders in the Newborn Infant, 4th ed. W.B. Saunders, PhiladelphiaGoogle Scholar
  8. Balci S, Bostanoglu S, Altinok G, Ozaltin (1999) Sibs diagnosed prenatally with situs inversus totalis, renal and pancreatic dysplasia and cysts. Am J Med Genet 82:166–169PubMedCrossRefGoogle Scholar
  9. Balci S, Bostanoglu S, Altinok G, Ozaltin F (2000) Three sibs diagnosed prenatally with situs inversus totalis, renal and pancreatic dysplasia and cysts. Am J Med Genet 90:185–187PubMedCrossRefGoogle Scholar
  10. Ballard ET (1996) Ultrashort segment Hirschsprung's disease: a case report. Pediatr Pathol Lab Med 16:319–325PubMedCrossRefGoogle Scholar
  11. Barr LC, Booth J, Filipe MI, Lawson JON (1985) Clinical evaluation of the histochemical diagnosis of Hirschsprung's disease. Gut 26:393–399PubMedCrossRefGoogle Scholar
  12. Bax NMA, Pearse RG, Dommering N, Molenaar JC (1980) Perforation of the appendix in the neonatal period. J Pediatr Surg 15:200–202PubMedCrossRefGoogle Scholar
  13. Bell MJ, Keating JP, Ternberg JL, Bower RJ (1981) Perforated stress ulcers in infants. J Pediatr Surg 16:998–1002PubMedCrossRefGoogle Scholar
  14. Bell MJ, Ternberg JL, Keating JP, et al. (1978) Prepyloric gastric antral web: a puzzling epidemic. J Pediatr Surg 13:307–313PubMedCrossRefGoogle Scholar
  15. Benacerraf BR, Saltzman DH, Estroff JA, Frigoletto FD (1990) Abnormal karyotype of fetuses with omphalocele: prediction based on omphalocele contents. Obstet Gynecol 75:317–319PubMedGoogle Scholar
  16. Benson CD, Lloyd JR, Smith JD (1960) Resection and primary anastomosis in the management of stenosis and atresia of the jejunum and ileum. Pediatrics 26:265–272PubMedGoogle Scholar
  17. Bentley JFR, Smith JR (1960) Developmental posterior enteric remnants and spinal malformations. The split notochord syndrome. Arch Dis Child 35:76–86PubMedCrossRefGoogle Scholar
  18. Berdon WE, Baker DH, Wigger HJ, et al. (1975) Calci-fi ed intraluminal meconium in newborn males with imperforate anus. AJR 125:449–455Google Scholar
  19. Bernstein J, Vawter G, Harris GBC, Young V, Hillman LS (1960) The occurrence of intestinal atresia in newborns with meconium ileus. Am J Dis Child 99:804–818Google Scholar
  20. Berry CL, Fraser GC (1968) The experimental production of colitis in the rabbit with particular reference to Hirschsprung's disease. J Pediatr Surg 3:36–42CrossRefGoogle Scholar
  21. Bilen BT, Alaybeyoglu N, Arslan A, et al. (2004) Obstructive congenital gingival granular cell tumour Int J Pediatr Otorhynolaryngol 68:1567–1571.CrossRefGoogle Scholar
  22. Bill AH, Chapman ND (1962) The enterocolitis of Hirschsprung's disease. Am J Surg 103:70–74CrossRefGoogle Scholar
  23. Bille C, Skytthe A, Vach W, et al. (2005) Parent's age and risk of facial clefts. Epidemiology 16:311–316PubMedCrossRefGoogle Scholar
  24. Bissler JJ, Klein RL (1988) Alimentary tract duplications in children: case and literature review. Clin Pediatr 27:152–157CrossRefGoogle Scholar
  25. Blakely ML, Lally KP, McDonald S, et al. (2005) Postoperative outcomes of extremely low birth-weight infants with necrotizing enterocolitis or isolated intestinal perforation: a prospective cohort study by the NICHD Neonatal Research Network. Ann Surg 241:984–989PubMedCrossRefGoogle Scholar
  26. Blank E, Chisolm AJ (1973) Congenital microgastria, a case report with a 26 year follow-up. Pediatrics 51:1037–1041PubMedGoogle Scholar
  27. Blisard KS, Barton SA (1986) Neonatal haemochro-matosis. Hum Pathol 17:376–383PubMedCrossRefGoogle Scholar
  28. Blyth H, Dickson JAS (1969) Apple peel syndrome (congenital intestinal atresia). A family study of seven index patients. J Med Genet 6:275–277PubMedCrossRefGoogle Scholar
  29. Boué A, Muller F, Nezelof C, et al. (1986) Prenatal diagnosis in 200 pregnancies with a 1–in-4 risk of cystic fi brosis. Hum Genet 74:288–297PubMedCrossRefGoogle Scholar
  30. Boyd PA, Bhattacharjee A, Gould S, Manning N, Chamberlain P (1998) Outcome of prenatally diagnosed anterior abdominal wall defects. Arch Dis Child 78:F209–F213.Google Scholar
  31. Brearly S, Armstrong GR, Nairn R, et al. (1987) Pseudo-membranous colitis: A lethal complication of Hirschsprung's disease unrelated to antibiotic usage. J Pediatr Surg 22:257–259PubMedCrossRefGoogle Scholar
  32. Bremer JL (1944) Diverticula and duplications of the intestinal tract. Arch Pathol 38:132–140Google Scholar
  33. Brink DA, Balsara ZN (1991) Prenatal ultrasound detection of intra-abdominal pulmonary sequestration with postnatal MRI correlation. Pediatr Radiol 21:227PubMedCrossRefGoogle Scholar
  34. Bunton GL, Durbin GM, McIntosh N, et al. (1977) Necro-tising enterocolitis. Arch Dis Child 52:772–777PubMedCrossRefGoogle Scholar
  35. Burge D, Drewett M (2004) Meconium plug obstruction. Pediat Surg Int 20:108–110CrossRefGoogle Scholar
  36. Cantrell JR, Haller JA, Ravitch MM (1958) A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium and heart. Surg Gynecol Obstet 107:602PubMedGoogle Scholar
  37. Carinci F, Rollo R, Farina A, et al. (2005) Non-syndromic facial clefts in Southern Italy: pattern analysis according to gender, history of maternal smoking, folic acid intake and familial diabetes. J Craniofac Surg 33:91–94Google Scholar
  38. Carneiro PMR, Brereton RJ, Drake DP et al. (1992) Enterocolitis in Hirschsprung's disease. Pediatr Surg Int 7:356–360CrossRefGoogle Scholar
  39. Carter CO, Evans KA (1969) Inheritance of congenital pyloric stenosis. J Med Genet 6:233–239PubMedCrossRefGoogle Scholar
  40. Chang CH, Perrin EV, Bove KE (1983) Pyloric atresia associated with epidermolysis bullosa: special reference to pathogenesis. Pediatr Pathol 1:449–457PubMedCrossRefGoogle Scholar
  41. Chang J, Brueckner M, Rouloukian RJ (1993) Intestinal rotation and fi xation abnormalities in heterotaxia: early detection and management. J Pediatr Surg 28:1281–1285PubMedCrossRefGoogle Scholar
  42. Clark JA, Lane RH, Maclennan, et al. (2005) Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 288:G755– 762PubMedCrossRefGoogle Scholar
  43. Clatworthy HW, Howard WHR, Lloyd J (1956) The meconium plug syndrome. Surgery 39:131–142PubMedGoogle Scholar
  44. Cochran WD, Davis HT, Smith CS (1968) Advantages and complications of umbilical artery catheterisation in the newborn. Pediatrics 42:769–777PubMedGoogle Scholar
  45. Coffi n CM, Pappin AL (1997) Polyps and neoplasms of the gastrointestinal tract in childhood and adolescence. In: Dahms BB, Qualman SJ (eds) Perspectives in Paediatric Pathology, vol 20. Karger, Basel, pp. 127–171Google Scholar
  46. Colbourne MT (2004) The complex genetics of cleft lip and palate. Eur J Orthod 26:7–16CrossRefGoogle Scholar
  47. Collins DL, Kimura K, Morgan A (1986) Multiple intestinal atresia and amyoplasia congenita in four unrelated infants: a new association. J Pediatr Surg 21:331–333PubMedCrossRefGoogle Scholar
  48. Cook RCM, Rickham PP (1969) Neonatal intestinal obstruction due to milk curds. J Pediatr Surg 4:599–605PubMedCrossRefGoogle Scholar
  49. Cooper WO, Griffi n MR, Arbogast P, et al. (2002) Very early exposure to erythromycin and infantile hyper-trophic pyloric stenosis. Arch Pediatr Adolesc Med 156:647–650PubMedGoogle Scholar
  50. Corkery JJ, Dubowitz V, Lister J, Moosa A (1968) Colonic perforation after exchange transfusion. Br Med J 2:345–349CrossRefGoogle Scholar
  51. Cotton PB (1980) Congenital anomaly of pancreas divisum as cause of obstructive pain and pancreatitis. Gut 21:105–114PubMedCrossRefGoogle Scholar
  52. Coutinho HB, Carmona de Mota H, Coutinho VB, et al. (1998) Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with nec-rotizing enterocolitis. J Clin Pathol 51:512–514PubMedCrossRefGoogle Scholar
  53. Cruickshank AH (1986) Pathology of the Pancreas. Springer, Berlin, Heidelberg, New YorkGoogle Scholar
  54. Cunningham P, Rose JS, Sokol A, Bleicher MA (1980) A case of neonatal intussusception. J Pediatr Surg 15:203–204PubMedCrossRefGoogle Scholar
  55. De Krijger RR, Albers MJ, Bogers AJ, Mooi WJ (2004) Heterotopic pancreatic tissue presenting as solid and cystic lung lesion: a very unusual bronchopulmonary foregut malformation. Pediatr Dev Pathol 7:204– 209PubMedCrossRefGoogle Scholar
  56. De Perrot M, Brundler M, Tutsch M, Mentha G, Morel P (2000) Mesenteric cysts. Towards less confusion? Dig Surg 17:323–328CrossRefGoogle Scholar
  57. De Serpa Pinto MV, DeMagalhaes MH, Nunes FD (2002) Moebius syndrome with oral involvement. Int J Pediatr Dent 12:446–449CrossRefGoogle Scholar
  58. Déchelotte PJ, Mulliez NM, Bouvier RJ, Vanlieféringhen P, Lémery DJ (1992) Pseudo-meconium ileus due to cytomegalovirus infection: a report of three cases. Pediatr Pathol 12:73–82PubMedCrossRefGoogle Scholar
  59. deLorimier AA, Fonkalsrud EW, Hays DM (1969) Congenital atresia and stenosis of the jejunum and ileum. Surgery 65:819–827Google Scholar
  60. Denes J, Honti J, Leb J (1967) Dorsal herniation of the gut: a rare manifestation of the split notochord syndrome. J Pediatr Surg 2:359–363PubMedCrossRefGoogle Scholar
  61. Deurloo JA, Smit BJ, Ekkelkamp S, Aronson DC (2004) Oesophageal atresia in premature infants: an analysis of morbidity and mortality over a period of 20 years. Acta Paediatr 93:394–399PubMedCrossRefGoogle Scholar
  62. deVries P (1980) The pathogenesis of gastroschisis and omphalocele. J Pediatr Surg 15:245–251CrossRefGoogle Scholar
  63. Dick AC, Ardill J, Potts SR, Dodge JA (2001) Gastrin, somatostatin and hypertrophic pyloric stenosis. Acta Paediatr 90:879–882PubMedCrossRefGoogle Scholar
  64. Dickson JAS (1970) Apple peel small bowel: an uncommon variant of duodenal and jejunal atresia. J Pediatr Surg 5:595–600PubMedCrossRefGoogle Scholar
  65. Dickson JAS, Variend S (1983) Colonic neuronal dysplasia. Acta Paediatr Scand 72:635–637PubMedCrossRefGoogle Scholar
  66. Dimmick JE, Hardwick DF (1992) Gastrointestinal system and exocrine pancreas. In: Dimmick JE, Kalousek DK (eds) Developmental Pathology of the Embryo and Fetus. JB Lippincott, Philadelphia, pp. 509–544Google Scholar
  67. Dirkes K, Crombleholme TM, Craigo SD, et al. (1995) The natural history of meconium peritonitis diagnosed in utero. J Pediatr Surg 30:979–982PubMedCrossRefGoogle Scholar
  68. Dohn K, Povlsen O (1951) Enterocystomas. Report of six cases. Acta Chir Scand 102:21–35Google Scholar
  69. Donnison AB, Shwachman H, Gross RE (1966) A review of 164 children with meconium ileus seen at the Children's Hospital Medical Center, Boston. Pediatrics 37:833–850PubMedGoogle Scholar
  70. Dudgeon DL, Coran AG, Lauppe FA, Hodgman JE, Rosenkrantz JG (1973) Surgical management of acute necrotising enterocolitis in infancy. J Pediatr Surg 8:607–614PubMedCrossRefGoogle Scholar
  71. Duncan BW, Adzick NS, Eraklis A (1992) Retroperito-neal alimentary tract duplications detected in utero. J Pediatr Surg 27:1231–1233PubMedCrossRefGoogle Scholar
  72. Durham Smith E (1968) Urinary anomalies and complications in imperforate anus and rectum. J Pediatr Surg 3:337–349CrossRefGoogle Scholar
  73. Eckoldt F, Heling KS, Woderich R, et al. (2003) Meco-nium peritonitis and pseudo-cyst formation: prenatal diagnosis and post-natal course. Prenat Diag 23:904–908CrossRefGoogle Scholar
  74. Elhalaby EA, Coran AG, Blane CE, et al. (1995) Entero-colitis associated with Hirschsprung's disease: a clinical-radiological characterization based on 168 patients. J Pediatr Surg 30:76–83PubMedCrossRefGoogle Scholar
  75. Elliott K, Knight J (1974) Size at birth. Ciba Found Symp 27:202–203Google Scholar
  76. Emura T, Hashizume K, Asashims M (2003) Experimental study of the embryogenesis of gastrointestinal duplication and enteric cyst. Pediatr Surg Int 19:147–151PubMedGoogle Scholar
  77. Engel RR, Virnig NL, Hunt CE, Levitt MD (1973) Origin of mural gas in necrotising enterocolitis. Pediatr Res 7:292Google Scholar
  78. Engum SA, Petrites M, Rescorla J, et al. (1993) Familial Hirschsprung's disease: 20 cases in 12 kindreds. J Pediatr Surg 28:1286–1290PubMedCrossRefGoogle Scholar
  79. Erez I, Reish O, Kovalivker M, et al. (2001) Congenital short-bowel syndrome and malrotation: clinical presentation and outcome of six affected offspring in three repeated families. Eur J Pediatr Surg 11:331– 334PubMedCrossRefGoogle Scholar
  80. Esterly JR, Baghdassarian OM (1963) Presacral neuro-enteric cyst: an unusual malformation resulting from persistence of the neuroenteric canal. Bull Johns Hopkins Hosp 113:202–210PubMedGoogle Scholar
  81. Faix RG, Adams JT (1994) Neonatal necrotizing entero-colitis: current concepts and controversies. Adv Pediatr Infect Dis 9:1–36PubMedGoogle Scholar
  82. Fallon M, Gordon ARG, Lendrum AC (1954) Mediasti-nal cysts of foregut origin associated with vertebral abnormalities. Br J Surg 41:520–533PubMedCrossRefGoogle Scholar
  83. Favara BE, Franciosi RA, Akers DR (1971) Enteric duplications. Thirty seven cases: a vascular theory of pathogenesis. Am J Dis Child 122:501– 506Google Scholar
  84. Fonkalsrud EW, deLorimier AA, Hays DM (1969) Congenital atresia and stenosis of the duodenum. Pediatrics 43:79–83PubMedGoogle Scholar
  85. Forouhar F (1982) Meconium peritonitis. Am J Clin Pathol 78:208–213PubMedGoogle Scholar
  86. Franz ID, L'Heureux P, Engel RR, Hunt CE (1975) Necrotising enterocolitis. J Pediatr 86:259–263CrossRefGoogle Scholar
  87. Fuhr AH, Krogh PHJ (1972) Congenital epulis of the newborn. J Oral Surg 30:30–35PubMedGoogle Scholar
  88. Fujimoto T, Hata J, Yokoyama S, Mitomi T (1989) A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: analysis in human embryos with special reference to the pathogenesis of Hirschsprung's disease. J Pediatr Surg 24:550–556PubMedCrossRefGoogle Scholar
  89. Garrett JR, Howard ER, Nixon HH (1969) Autonomic nerves in rectum and colon in Hirschsprung's disease. A cholinesterase and catecholamine histochemical study. Arch Dis Child 44:406–417PubMedCrossRefGoogle Scholar
  90. Garza-Cox S, Keeney SE, Angel CA, Thompson LL, Swischuck LE (2004) Meconium obstruction in the very low birthweight premature infant. Pediatrics 114:285–290PubMedCrossRefGoogle Scholar
  91. Ghosh A, Griffi ths DM (1998) Rectal biopsy in the investigation of constipation. Arch Dis Child 79:266–268PubMedCrossRefGoogle Scholar
  92. Goldberg HM, Johnson TP (1962) Posterior abdomi-nothoracic enteric duplications. Br J Surg 50:445– 449CrossRefGoogle Scholar
  93. Goto S, Ikeda K, Toyohara T (1984) Histochemical con-fi rmation of the acetylcholinesterase-activity in rectal suction biopsy from neonates with Hirschsprung's disease. Z Kinderchir 39:246–249PubMedGoogle Scholar
  94. Gough MH (1961) Congenital abnormalities of the anus and rectum. Arch Dis Child 36:146–151PubMedCrossRefGoogle Scholar
  95. Greenwood RD, Rosenthal A, Nadas AS (1974) Cardiovascular malformations associated with omphalocele. J Pediatr 85:818–821PubMedCrossRefGoogle Scholar
  96. Grosfeld JL, Dalsing MC, Hull M, Weber TR (1983) Neonatal apnea, xanthines, and necrotising entero-colitis. J Pediatr Surg 18:80–84PubMedCrossRefGoogle Scholar
  97. Grosfeld JL, O'Neill JA, Clatworthy HW (1970) Enteric duplications in infancy and childhood: an 18 year review. Ann Surg 172:83–90PubMedGoogle Scholar
  98. Hackam DJ, Reblock KK, Redlinger RE, Barksdale EM Jr (2004) Diagnosis and outcome of Hirschsprung's disease: does age really matter? Pediatr Surg Int 20:319–322PubMedCrossRefGoogle Scholar
  99. Hackam DJ, Upperman JS, Grishin A, Ford AR (2005) Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotiz-ing enterocolitis. Semin Pediatr Surg 14:49–57PubMedCrossRefGoogle Scholar
  100. Hakanson DO, Oh W (1977) Necrotising enterocolitis and hyperviscosity in the newborn infant. J Pediatr 90:458–461PubMedCrossRefGoogle Scholar
  101. Hardwick DF, Kalousek DK (1992) Gastrointestinal system and exocrine pancreas. In: Dimmick JE, Kalousek DK (eds) Developmental Pathology of the Embryo and Fetus. JB Lippincott, Philadelphia, pp. 509–544Google Scholar
  102. Hartwig NG, Vermeij-Keers CHR, deVries HE, Kagie M, Kragt H (1989) Limb body wall malformation complex: an embryologic etiology? Hum Pathol 20:1071–1077PubMedCrossRefGoogle Scholar
  103. Hashida Y, Jaffe R, Yunis EJ (1983) Pancreatic pathology in trisomy 13: specifi city of the morphologic lesion. Pediatr Pathol 1:169–178PubMedCrossRefGoogle Scholar
  104. Heller K, Waag KL, Beyersdorf F (1989) Intestinal duplications–intestinal diverticula–segmental dilatation of the intestine: a common genetic complex. Pediatr Surg Int 4:249–253CrossRefGoogle Scholar
  105. Hershenson MB, Brouillette RT, Klemka L, et al. (1985) Respiratory insuffi ciency in newborns with abdominal wall defects. J Pediatr Surg 20:348–353PubMedCrossRefGoogle Scholar
  106. Higginbottom MC, Jones KL, Hall BD, Smith DW (1979) The amniotic band disruption complex: timing of amniotic rupture and variable spectra of consequent defects. J Pediatr 95:544–549PubMedCrossRefGoogle Scholar
  107. Holder TM, Cloud DT, Lewis JE, Pilling GP IV (1964) Esophageal atresia and tracheoesophageal fi stula. Pediatrics 34:542–549PubMedGoogle Scholar
  108. Holder-Espinasse M, Ahmad Z, Hamill J, et al. (2004) Familial syndromic duodenal atresia: Feingold syndrome. Eur J Pediatr Surg 14:112–116PubMedCrossRefGoogle Scholar
  109. Holgersen LO (1981) The etiology of spontaneous gastric perforation of the newborn: a re-evaluation. J Pediatr Surg 16:608–613PubMedCrossRefGoogle Scholar
  110. Holsclaw DS, Eckstein HB, Nixon HH (1965) Meconium ileus. A 20 year review of 109 cases. Am J Dis Child 109:101–113PubMedGoogle Scholar
  111. Howard FM, Flynn DM, Bradley JM, Noone P, Swawatkowski M (1977) Outbreak of necrotising enterocolitis caused by Clostridium butyricum: Lancet 2:1099–1102PubMedCrossRefGoogle Scholar
  112. Howell WE, Stein H, Romaro AJ (1972) Sublingual dermoid cyst in infant: report of case. J Oral Surg 30:437–441PubMedGoogle Scholar
  113. Hoyme HE, Higginbottom MC, Jones KL (1981) The vascular pathogenesis of gastroschisis: intrauterine interruption of the omphalomesenteric artery. J Pediatr 98:228–231PubMedCrossRefGoogle Scholar
  114. Hsueh W, Caplan MS, Qu X-W, et al. (2002) Neonatal necrotizing enterocolitis: clinical considerations and pathogenic concepts. Pediatr Dev Pathol 6:6–23PubMedCrossRefGoogle Scholar
  115. Hsueh W, Caplan MS, Tan X, McKendrick W, Gonzalez-Crussi F (1998) Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. Pediatr Devel Pathol 1:2–16CrossRefGoogle Scholar
  116. Hu MX, Methratta S (2001) An unusual case of neonatal peritoneal calcifi cations associated with hydrometro-colpos. Pediatr Radiol 31:742–744PubMedCrossRefGoogle Scholar
  117. Huntley CC, Shaffner L, Challa VR, Lyerly AD (1982) Histochemical diagnosis of Hirschsprung disease. Pediatrics 69:775–761Google Scholar
  118. Jackson JM (1963) Annular pancreas and duodenal obstruction in the neonate. A review. Arch Surg 87:379–383PubMedGoogle Scholar
  119. Jackson RH, Bird AR (1961) Meckel's diverticulum in childhood. Br Med J 2:1399–1402PubMedCrossRefGoogle Scholar
  120. Jaffe R (1991) The pancreas. In: Wigglesworth JS, Singer DB (eds) Fetal and Perinatal Pathology, vol 2. Blackwell Scientifi c Publications, Boston, pp. 1021– 1055.Google Scholar
  121. Javid PJ, Jaksic T, Skarsgard ED, et al. (2004) Survival rate in congenital diaphragmatic hernia: the experience of the Canadian Neonatal Network. Pediatr Surg 39:657–660CrossRefGoogle Scholar
  122. Johnston JH, Penn IA (1966) Exstrophy of the cloaca. Br J Urol 38:302–307PubMedCrossRefGoogle Scholar
  123. Jones KL (1997) Smith's Recognizable Patterns ofHuman Malformations, 5th ed. WB Saunders,PhiladelphiaGoogle Scholar
  124. Jones PG (1963) Exomphalos (syn. omphalocele). Areview of 45 cases. Arch Dis Child 38:180–187CrossRefPubMedGoogle Scholar
  125. Kallen K, Castilla EE, Robert E, Mastriacovo P, Kallen B (2000) OEIS complex—a population study. Am J Med Genet 92:62–68PubMedCrossRefGoogle Scholar
  126. Kapur RP (1999a) Hirschsprung disease and other enteric dysganglionoses. Crit Rev Clin Lab Sci 36:225–273CrossRefGoogle Scholar
  127. Kapur RP (1999b) Early death of neural crest cells is responsible for total aganglionosis in Sox10(Dom)/ Sox10(Dom) mouse embryos. Pediatr Dev Pathol 2:559–569CrossRefGoogle Scholar
  128. Kapur RP (2001) Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models. J Pathol 194:277–288PubMedCrossRefGoogle Scholar
  129. Kapur RP (2003) Neuronal dysplasia: a controversial pathological correlate of intestinal pseudo-obstruction. Am J Med Genet 122:287–293CrossRefGoogle Scholar
  130. Kelly N, Friend K, Boyle P, et al. (2004) The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery 136:557–566PubMedCrossRefGoogle Scholar
  131. Kiesewetter WB, Smith JE (1958) Malrotation of the midgut in infancy and childhood. AMA Arch Surg 77:483–491PubMedGoogle Scholar
  132. King A, Mueller RF, Heeley AR, Roberton NRC (1986) Diagnosis of cystic fi brosis in premature infants. Pediatr Res 20:536–541PubMedCrossRefGoogle Scholar
  133. King DR, Savrin R, Boles ET (1980) Gastroschisis update. J Pediatr Surg 15:553–557PubMedCrossRefGoogle Scholar
  134. Kliegman RM (1990) Neonatal necrotising enterocolitis: bridging the basic science with the clinical disease. J Pediatr 117:833–835PubMedCrossRefGoogle Scholar
  135. Konje JC, de Chazal R, MacFadyen U, Taylor DJ (1995) Antenatal diagnosis and management of meconium peritonitis: a case report and review of the literature. Ultrasound Obstet Gynaecol 6:66–69CrossRefGoogle Scholar
  136. Kopel FB (1972) Gastrointestinal manifestations of cystic fi brosis. Curr Clin Concepts 62:483–491Google Scholar
  137. Lack EE (1985) Extragonadal germ cell tumors of the head and neck region: review of 16 cases. Hum Pathol 16:56–64PubMedCrossRefGoogle Scholar
  138. Lake BD (1981) Metabolic disorders: general considerations. In: Berry CL (ed) Pediatric Pathology. Springer-Verlag, Berlin, Heidelberg, New York, pp. 617–639Google Scholar
  139. Lemire RJ, Graham CB, Beckwith JB (1971) Skin-covered sacrococcygeal masses in infants and children. J Pediatr 79:948–954PubMedCrossRefGoogle Scholar
  140. Lemons JA, Ridenour R, Orsini EN (1979) Congenital absence of the pancreas and intrauterine growth retardation. Pediatrics 64:255–257PubMedGoogle Scholar
  141. Lin HC, Su BH, Chen AC, et al. (2005) Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 115:1–4PubMedCrossRefGoogle Scholar
  142. Lister J, Rickham PP (1980) Hirschsprung's disease. In: Rickham PP, Lister J, Irving IM (eds) Neonatal Surgery, 2nd ed. Butterworths, London, pp. 441– 455Google Scholar
  143. Lloyd JR (1969) The etiology of gastrointestinal perforations in the newborn. J Pediatr Surg 4:77–84PubMedCrossRefGoogle Scholar
  144. Lorimer WS, Ellis DG (1966) Meconium peritonitis. Surgery 60:470–475PubMedGoogle Scholar
  145. Louw JH (1966) Jejunoileal atresia and stenosis. J Pediatr Surg 1:8–23CrossRefGoogle Scholar
  146. Luig M, Lui K, NSW and ACT NICUS Group (2005) Epidemiology of necrotizing enterocolitis-Part II: risks and susceptibility of premature infants during the surfactant era: a regional study. J Paediatr Child Health 41:174–179PubMedCrossRefGoogle Scholar
  147. Maka M, Stolt CC, Wegner M (2005) Identifi cation of Sox8 as a modifi er gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Dev Biol 277:155–169PubMedCrossRefGoogle Scholar
  148. Mann L, Feguson-Smith MA, Desai M, Gibson AAM, Raine PAM (1984) Prenatal assessment of anterior abdominal wall defects and their prognosis. Prenat Diagn 4:427–435PubMedCrossRefGoogle Scholar
  149. Marchildon MB, Buck BE, Abdenour G (1982) Necrotis-ing enterocolitis in the unfed infant. J Pediatr Surg 17:620–623PubMedCrossRefGoogle Scholar
  150. Martin LW, Perrin EV (1967) Neonatal perforation of the appendix in association with Hirschsprung's disease. Ann Surg 166:799–802PubMedCrossRefGoogle Scholar
  151. Martinez-Mora J, Boix-Ochoa J, Tresserra L (1971) Vascular tumours of the parotid region in children. Surg Gynecol Obstet 133:973–977PubMedGoogle Scholar
  152. Master V, Woods RH, Morris LL, Freeman J (2004) Gastric duplication cyst causing gastric outlet obstruction. Pediatr Radiol 34:574–576PubMedCrossRefGoogle Scholar
  153. McFadden DE, Pantzar JT (1992) Genital system. In: Dimmick JE, Kalousek DK (eds) Developmental Pathology of the Embryo and Fetus. JB Lippincott, Philadelphia, pp. 605–624Google Scholar
  154. McKenzie F, Turner A, Withers S, et al. (2002) Dominant inheritance of cleft palate, microstomia and micrognathia—possible linkage to the fragile site at 16q22(FRA 16B). Clin Dysmorph 11:237–241PubMedCrossRefGoogle Scholar
  155. McLetchie NGB, Purves JK, Saunders RL de CH (1954) The genesis of gastric and certain intestinal divertic-ula and enterogenous cysts. Surg Gynecol Obstet 99:135–141Google Scholar
  156. Meier-Ruge W (1974) Hirschsprung's disease: its aetiology, pathogenesis and differential diagnosis. Curr Top Pathol 59:131–179PubMedGoogle Scholar
  157. Merriam JC, Benirschke K (1959) Esophageal erosions in the newborn. Lab Invest 8:39–47PubMedGoogle Scholar
  158. Miller JP, Smith SD, Newman B, Sukarochana K (1988) Neonatal abdominal calcifi cation: Is it always meco-nium peritonitis? J Pediatr Surg 23:555–556PubMedCrossRefGoogle Scholar
  159. Miller ME, Graham JM, Higginbottom MC, Smith DW (1981) Compression-related defects from early amnion rupture: evidence for mechanical teratogen-esis. J Pediatr 98:292–297PubMedCrossRefGoogle Scholar
  160. Mizrahi A, Barlow O, Berdon W, Blanc WA, Silverman WA (1965) Necrotising enterocolitis in premature infants. J Pediatr 66:697–706PubMedCrossRefGoogle Scholar
  161. Moore TC, Schumacker HB (1952) Intussusception of ileum through persistent omphalomesenteric duct. Surgery 31:278–284PubMedGoogle Scholar
  162. Morrell MT, Keynes M (1981) Annular pancreas. In: Keynes WM, Keith RG (eds) The Pancreas. Heine-mann, London, pp. 159–168Google Scholar
  163. Muller F, Aubry MC, Gasser B, et al. (1985) Prenatal diagnosis of cystic fi brosis. Prenat Diagn 5:109–117PubMedCrossRefGoogle Scholar
  164. Nacheff M, Morgan R, Einsenstein EM (1964) The surgical treatment of perforated duodenal ulcer in the newborn. Am J Surg 108:717–723PubMedCrossRefGoogle Scholar
  165. Nakayama DK, Harrison MR, Gross BH, et al. (1984) Management of the fetus with an abdominal wall defect. J Pediatr Surg 19:408–413PubMedCrossRefGoogle Scholar
  166. Neal WA, Reynolds JW, Jarvis CW, Williams HJ (1972) Umbilical artery catheterisation: demonstration of arterial thrombosis by aortography. Pediatrics 50:6–13PubMedGoogle Scholar
  167. Neilson IR, Yazbeck S (1990) Ultrashort Hirschsprung's disease: myth or reality. J Pediatr Surg 25:1135– 1138PubMedCrossRefGoogle Scholar
  168. Nicolaides KH, Rodeck CH, Fosden CM (1986) Rapid karyotyping in non-lethal fetal malformations. Lancet 1:283–287PubMedCrossRefGoogle Scholar
  169. Nixon HH, Tawes R (1971) Etiology and treatment of small intestinal atresia: analysis of a series of 127 jejunoileal atresias and comparison with 62 duodenal atresias. Surgery 69:41–51PubMedGoogle Scholar
  170. Nyberg DA, Fitzsimmons J, Mack LA, et al. (1989) Chromosomal abnormalities in fetuses with omphalocele. J Ultrasound Med 8:299–308PubMedGoogle Scholar
  171. Okamoto E, Ueda T (1967) Embryogenesis of intramural ganglia of the gut and its relation to Hirschsprung's disease. J Pediatr Surg 2:437–443CrossRefGoogle Scholar
  172. Olsen MM, Luck SR, Lloyd-Still J, Raffensperger JG (1982) The spectrum of meconium disease in infancy. J Pediatr Surg 17:479–481PubMedCrossRefGoogle Scholar
  173. Olson JL, Marcus JR, Zuker RM (2005) Congenital epulis. J Craniofasc Surg 16:161–164CrossRefGoogle Scholar
  174. Oppenheimer EH, Esterly JR (1962) Observations in cystic fi brosis of the pancreas. II. Neonatal intestinal obstruction. Bull Johns Hopkins Hosp 111:1PubMedGoogle Scholar
  175. Oppenheimer EH, Esterly JR (1975) Pathology of cystic fi brosis. Review of literature and comparison with 146 autopsied cases. In: Rosenberg HS, Bolande RP (eds) Perspectives in Pediatric Pathology, vol 2. Year Book Medical Publishers, Chicago, pp. 241 278Google Scholar
  176. Parikh DH, Tam PKH, Lloyd DA, van Velzen D, Edgar DH (1992) Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschsprung's disease. J Pediatr Surg 27:991– 996PubMedCrossRefGoogle Scholar
  177. Parisi MA, Kapur RP (2000) Genetics of Hirschsprung disease. Curr Opin Pediatr 12:610–617PubMedCrossRefGoogle Scholar
  178. Park RW, Grand RJ (1981) Gastrointestinal manifestations of cystic fi brosis: a review. Gastroenterology 81:1143–1161PubMedGoogle Scholar
  179. Parmigiani S, Giordano G, Fellagra G, et al. (2004) A rare case of multiple congenital epulis. J Matern Fetal Neonatal Med 16(suppl 2):55–58PubMedCrossRefGoogle Scholar
  180. Parrish RA, Sherman RT, Wilson H (1964) Spontaneous rupture of the gastro-enteric tract in the newborn: a report of 13 cases and description of a characteristic x-ray fi nding. Ann Surg 159:244–251PubMedCrossRefGoogle Scholar
  181. Partridge JP, Gough MH (1961) Congenital abnormalities of the anus and rectum. Br J Surg 49:37–49PubMedCrossRefGoogle Scholar
  182. Philippart AI, Reed JO, Geargeson KE (1975) Neonatal small left colon syndrome: intramural not intralumi-nal obstruction. J Pediatr Surg 10:733–739PubMedCrossRefGoogle Scholar
  183. Picard E, Aviram M, Yahav Y, et al. (2004) Familial concordance of phenotype and microbial variation among siblings with CF. Pediatr Pulmon 38:292– 297CrossRefGoogle Scholar
  184. Piotrowska AP, Solari V, Puri P (2003) Distribution of heme oxygenase-2 in nerves and interstitial cells of Cajal in the normal pylorus and in infantile hyper-trophic pyloric stenosis. Arch Pathol Lab Med 127:1182–1186PubMedGoogle Scholar
  185. Pokorny WJ, McGill CW, Harberg FJ (1984) Morgagni hernias during infancy: presentation and associated anomalies. J Pediatr Surg 19:394–397PubMedCrossRefGoogle Scholar
  186. Pumberger W, Birnbacher R, Pomberger G, Dentinger J (2002) Duodeno-jejunal atresia with volvulus, absent dorsal root mesentery, and absent superior mesenteric artery: a hereditary compound structure in duodenal atresia? Am J Med Genet 109:52–55PubMedCrossRefGoogle Scholar
  187. Puri P, Lake BD, Gorman F, O'Donnell B, Nixon HH (1983) Megacystis–microcolon–intestinal hypoperi-stalsis syndrome: a visceral myopathy. J Pediatr Surg 18:64–69PubMedCrossRefGoogle Scholar
  188. Qualman SJ, Murray R (1994) Aganglionosis and related disorders. Hum Pathol 25:1141–1149PubMedCrossRefGoogle Scholar
  189. Qualman SJ, Pysher T, Schauer G (1997) Hirschsprung's disease: differential diagnosis and sequelae. In: Dahms BB, Qualman SJ (eds) Perspectives in Pediat-ric Pathology, vol 20. Karger, Basel, Switzerland, pp. 111–126.Google Scholar
  190. Quan L, Smith DW (1973) The VATER association. J Pediatr 82:104–107PubMedCrossRefGoogle Scholar
  191. Reiquam CW, Allen RP, Akers DR (1965) Normal and abnormal small bowel lengths. An analysis of 389 autopsy cases in infants and children. Am J Dis Child 109:447–451Google Scholar
  192. Ren Y, Lin CL, Li Z, et al. (2005) Up-regulation of mac-rophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopa-thology 46:659–667CrossRefGoogle Scholar
  193. Rickham PP (1955) Peritonitis in the neonatal period. Arch Dis Child 30:23–31PubMedCrossRefGoogle Scholar
  194. Rickham PP, Boeckman CR (1965) Neonatal meconium obstruction in the absence of mucovisicidosis. Am J Surg 109:173–177PubMedGoogle Scholar
  195. Robertson FM, Crombleholme TM, Paidas M, Harris, BH (1994) Prenatal diagnosis and management of gastrointestinal anomalies. Semin Perinatol 18:182– 195PubMedGoogle Scholar
  196. Rodin AE, Nichols MM, Hsu FL (1973) Necrotising enterocolitis occurring in full-term neonates at birth. Arch Pathol 96:335–338PubMedGoogle Scholar
  197. Rohde RA, Hodgman JE, Cleland RS (1964) Multiple congenital anomalies in the E1-trisomy (Group 16– 18) syndrome. Pediatrics 33:258–270PubMedGoogle Scholar
  198. Rotenberg B, El-Hakim H, Lodha A, et al. (2002) Naso-pharyngeal teratocarcinosarcoma. Int J Pediatr Oto-rhynolaryngol 62:159–164CrossRefGoogle Scholar
  199. Rothschild HB, Storck A, Myers B (1953) Mesenteric occlusion in a newborn infant. J Pediatr 43:569– 572PubMedCrossRefGoogle Scholar
  200. Santulli TV, Amoury RA (1967) Congenital anomalies of the gastrointestinal tract. Pediatr Clin North Am 14:21–45PubMedGoogle Scholar
  201. Santulli TV, Blanc WA (1961) Congenital atresia of the intestine: pathogenesis and treatment. Ann Surg 151:939–948Google Scholar
  202. Santulli TV, Schullinger JN, Heird WC, et al. (1975) Acute necrotising enterocolitis in infancy: a review of 64 cases. Pediatrics 55:376–387PubMedGoogle Scholar
  203. Sarioglu A, Tanyel FC, Buyukpamukcu N, Hicsommez A (1997) Hirschsprung-associated congenital anomalies. Eur J Pediatr Surg 7:331–337PubMedCrossRefGoogle Scholar
  204. Saur D, Vanderwinden JM, Seidler B, et al. (2004) Single—nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthetase exon 1c in infantile hypertrophic pyloric stenosis. Proc Natl Acad Sci USA 101:1662–1667PubMedCrossRefGoogle Scholar
  205. Scharli AF, Meier-Ruge W (1981) Localized and disseminated forms of neuronal intestinal dysplasia mimicking Hirschsprung's disease. J Pediatr Surg 16:164–170PubMedCrossRefGoogle Scholar
  206. Schutte BC, Murray JC (1999) The many faces and factors of orofacial clefts. Hum Mol Genet 8:1853–1859PubMedCrossRefGoogle Scholar
  207. Scott NM, Weinberg SM, Neiswanger K, Brandon CA, Marazita ML (2005) Hair whorls and handedness: informative markers in nonsyndromic cleft lip with or without cleft palate (NSCL/P)cases and their unaffected relatives. Am J Med Genet A 136:158– 161PubMedGoogle Scholar
  208. Sharma SC, Menon P (2005) Congenital microgastria with oesophageal stenosis and diaphragmatic hernia. Pediatr Surg Int 21:292–294PubMedCrossRefGoogle Scholar
  209. Shaw A (1975) The myth of gastroschisis. J Pediatr Surg 10:235–241PubMedCrossRefGoogle Scholar
  210. Siebert JR, Beckwith JB (1984) Left ventricular hypopla-sia in congenital diaphragmatic hernia. J Pediatr Surg 19:567–571PubMedCrossRefGoogle Scholar
  211. Siebert JR, Rutledge JC, Kapur RP (2005) Association of cloacal anomalies, caudal duplication and twinning. Pediatr Dev Pathol 8:339–354PubMedCrossRefGoogle Scholar
  212. Siplovich L, Davies MRQ, Kaschula ROC, Cywes S (1988) Intestinal obstruction in the newborn with congenital syphilis. J Pediatr Surg 23:810–813PubMedCrossRefGoogle Scholar
  213. Smith B, Clatworthy HW (1961) Meconium peritonitis: prognostic signifi cance. Pediatrics 27:967–970Google Scholar
  214. Smith JR (1960) Accessory enteric formations. Arch Dis Child 35:87–89PubMedCrossRefGoogle Scholar
  215. Smith NM, Chambers HM, Furness ME, Haan EA (1992) The OEIS complex (omphalocoele-extrophy-imper-forate anus-spinal defects): recurrence in sibs. J Med Genet 29:730–732PubMedCrossRefGoogle Scholar
  216. Smith NM, Chambers SE, Billson VR, et al. (1993) Oral teratoma (epignathus) with intracranial extension: a report of two cases. Prenat Diag 13:945–952CrossRefGoogle Scholar
  217. Smith VV, Milla PJ (1997) Histological phenotypes of enteric smooth muscle disease causing functional intestinal obstruction in childhood. Histopathology 31:112–122PubMedCrossRefGoogle Scholar
  218. Snyder WH, Chaffi n L (1954) Embryology and pathology of the intestinal tract: presentation of 40 cases of malrotation. Ann Surg 140:368–379PubMedCrossRefGoogle Scholar
  219. Srikanth MS, Ford EG, Isaacs H Jr, Mahour H (1993) Megacystis microcolon intestinal hypoperistalis syndrome: late sequelae and possible pathogenesis. J Pediatr Surg 28:957–959PubMedGoogle Scholar
  220. Stanier P, Moore GF (2004) Genetics of cleft lip and palate: syndrome genes contribute to the incidence of non-syndromic clefts. Hum Mol Genet 13: R73–R81PubMedCrossRefGoogle Scholar
  221. Stephens FD, Durham Smith E (1986) Classifi cation, identifi cation and assessment of surgical treatment of anorectal anomalies. Pediatr Surg Int 1:200–205CrossRefGoogle Scholar
  222. Stevens CA, Sargent LA (2002) Ablepharon-macrosto-mia syndrome. Am J Med Genet 107:30–37PubMedCrossRefGoogle Scholar
  223. Stevenson JK, Graham CB, Oliver TK, Goldenberg VE (1969) Neonatal necrotising enterocolitis—a report of twenty-one cases with fourteen survivors. Am J Surg 118:260–272PubMedCrossRefGoogle Scholar
  224. Stewart DR, Colodny AL, Dagget WC (1976) Malrota-tion of the bowel in infants and children: a 15 year review. Surgery 79:716–720PubMedGoogle Scholar
  225. Stocker JT, Heifetz SA (1987) Sirenomelia. A morphological study of 33 cases and review of the literature. Perspect Pediatr Pathol 10:7–50Google Scholar
  226. St-Vil D, Shaw KS, Lallier M, Yazbeck S, Di Lorenzo M (1996) Chromosomal anomalies in newborns with omphalocele. J Pediatr Surg 31:831–834PubMedCrossRefGoogle Scholar
  227. Suita S, Okamatsu T, Yamamoto T, et al. (2000) Changing profi le of abdominal wall defects in Japan: results of a National Survey. J Pediatr Surg 35:66–72PubMedCrossRefGoogle Scholar
  228. Sullivan PB (1996) Hirschsprung's disease. Arch Dis Child 74:5–7PubMedCrossRefGoogle Scholar
  229. Tan, HL, Yoong A, Yu CCW (2000) Ectopic pancreatic rests: a rare cause of persistent umbilical discharge. Pediatr Surg Int 116–117Google Scholar
  230. Tang TT, Glicklich M, Siegesmund KA, Oechler HW, McCreadie SR (1979) Neonatal cystic choristoma in submandibular salivary gland simulating cystic hygroma. Arch Pathol Lab Med 103:537–539Google Scholar
  231. Teich S, Schisgall RM, Anderson KD (1986) Ischemic enterocolitis as a complication of Hirschsprungv00274;s disease. J Pediatr Surg 21:143–145PubMedCrossRefGoogle Scholar
  232. Teitelbaum DH, Caniano DA, Qualman SJ (1989) The pathophysiology of Hirschsprung's-associated enterocolitis: importance of histologic correlates. J Pediatr Surg 24:1271–1277PubMedCrossRefGoogle Scholar
  233. Temtamy SA, Miller JD (1974) Extending the scope of the VATER association: defi nition of the VATER syndrome. J Pediatr 85:345–349PubMedCrossRefGoogle Scholar
  234. Thomaidis TS, Arey JB (1963) The intestinal lesions in cystic fi brosis of the pancreas. J Pediatr 63:444–453PubMedCrossRefGoogle Scholar
  235. Thomas DFM, Fernie DS, Bayston R, Spitz L, Nixon HH (1986) Enterocolitis in Hirschsprung's disease: a controlled study of the etiologic role of Clostridium diff-fi cile. J Pediatr Surg 21:22–25PubMedCrossRefGoogle Scholar
  236. Thurlbeck WM (1992) Respiratory System. In: Dimmick JE, Kalousek DK (eds) Developmental Pathology of the Embryo and Fetus. JB Lippincott, Philadelphia, pp. 437–466Google Scholar
  237. Tibboel D, Gaillard JLJ, Molenaar JC (1986) The importance of mesenteric vascular insuffi ciency in meconium peritonitis. Hum Pathol 17:411–416PubMedCrossRefGoogle Scholar
  238. Tibboel D, van Nie, CJ, Molenaar JC (1980) The effects of temporary general hypoxia and local ischemia on the development of the intestines: an experimental study. J Pediatr Surg 15:57–62PubMedCrossRefGoogle Scholar
  239. Touloukian RJ (1973) Gastric ischaemia: the primary factor in neonatal perforation. Clin Pediatr 12:219– 225Google Scholar
  240. Toyama WM (1972) Combined congenital defects of the anterior abdominal wall, sternum, diaphragm, pericardium, and heart: a case report and review of the syndrome. Pediatrics 50:778–792PubMedGoogle Scholar
  241. van der Putte SCJ (1986) Normal and abnormal development of the anorectum. J Pediatr Surg 21:434–440PubMedCrossRefGoogle Scholar
  242. van Dooren M, Tibboel D, Torfs C (2005) The co-occurrence of congenital diaphragmatic hernia, esopha-geal atresia/tracheoesophageal fi stula and lung hypoplasia. Birth Defects Res A Clin Mol Teratol 73:53–57PubMedCrossRefGoogle Scholar
  243. Variend S, Howat AJ (1988) Upper oesophageal gastric heterotopia: a prospective necropsy study in children. J Clin Pathol 41:742–545PubMedCrossRefGoogle Scholar
  244. Vawter GF, Tefft M (1966) Congenital tumours of the parotid gland. Arch Pathol 82:242–245PubMedGoogle Scholar
  245. Veeneklaas GMH (1952) Pathogenesis of intrathoracic gastrogenic cysts. Am J Dis Child 83:500–507Google Scholar
  246. Vieten D, Corfi eld A, Carroll D, Ramani P, Spicer R (2005) Impaired mucosal regeneration in neonatal necrotizing enterocolitis. Pediatr Surg Int 21:153– 160PubMedCrossRefGoogle Scholar
  247. Vinograd I, Mogle P, Peleg O, Alpan G, Lernau OZ (1983) Meconium disease in premature infants with very low birth weight. J Pediatr 103:963–966PubMedCrossRefGoogle Scholar
  248. Wallis C (1997) Diagnosing cystic fi brosis: blood, sweat, and tears. Arch Dis Child 76:85–91PubMedCrossRefGoogle Scholar
  249. Waterston DJ, Bonham Carter RE, Aberdeen E (1962) Oesophageal atresia: tracheo-oesophageal fi stula. A study of survival in 218 infants. Lancet I:819–822CrossRefGoogle Scholar
  250. Weaver DD, Mapstone CL, Yu P (1986) The Vater association. Analysis of 46 patients. Am J Dis Child 140:225–229PubMedGoogle Scholar
  251. Weinberg AG (1975) Hirschsprung's disease—a pathol-ogist's view. In: Rosenberg HS, Bolande RP (eds) Perspectives in Pediatric Pathology, vol 2. Year Book Medical Publishers, Chicago, pp. 207–239Google Scholar
  252. Weitzman JJ, Vanderhoof RS (1966) Jejunal atresia with agenesis of the dorsal mesentery. Am J Surg 111:443–449PubMedCrossRefGoogle Scholar
  253. White RB (1956) Meconium peritonitis: a surgical emergency. J Pediatr 48:793–796PubMedCrossRefGoogle Scholar
  254. Wiswell TE, Rawlings JS, Wilson JL, Pettett G (1979) Megacystis—microcolon—intestinal hypoperistalsis syndrome. Pediatrics 63:805–808PubMedGoogle Scholar
  255. Wu JL, Fang KH, Yeh GP, Chou PH, Hsieh CT (2004) Using color Doppler sonography to identify the perivesical umbilical arteries: a useful method in the prenatal diagnosis of omphalocele-extrophy-imper-forate anus-spinal defects complex. J Ultrasound Med 23:1211–1215PubMedGoogle Scholar
  256. Young DG, Wilkinson AW (1968) Abnormalities associated with neonatal duodenal obstruction. Surgery 63:832–836PubMedGoogle Scholar
  257. Yutani C, Sakurai M, Miyaji T, Okuno M (1973) Congenital short intestine. Arch Pathol 96:81–82PubMedGoogle Scholar

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© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Jean W. Keeling
    • 1
  1. 1.Infirmary of Edinburgh, University of EdinburghRoyal Hospital for Sick Children and RoyalEdinburghUK

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