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Radiotherapy in the Management of Testicular Germ Cell Tumors

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Urological Oncology

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Abstract

Radiotherapy as a routine treatment in patients with germinal cell cancers is offered to patients with early stages of seminomatous testicular cancers including clinical stage I and stage IIA and limited stage IIB disease. The rationale for radiotherapy in the management of seminoma with limited lymph node metastasis is its extreme sensitivity to radiotherapy, and the stepwise dissemination of tumor cells through lymphatics in the retroperitoneum (1). Radiotherapy, therefore, induces high cure rates in patients with low-volume seminomatous disease. Principles of management of various stages of testicular germ cell tumors (TGCTs), including relapse, is discussed in Chapter 17.1.

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References

  1. Classen J, Schmidberger H, Meisner C, et al. Radiotherapy for stages IIA/B testicular seminoma: final report of a prospective multi-center clinical trial. J Clin Oncol 2003;21:1101–1106.

    Article  PubMed  Google Scholar 

  2. von derMaase H, Rorth M, Walbom-Jorgensen S, et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. Br Med J 1986;293(6559):1398–1401.

    Article  Google Scholar 

  3. Duchesne GM, Horwich A, Dearnley DP, et al. Orchidectomy alone for stage I seminoma of the testis. Cancer 1990;65(5):1115–1118.

    Article  CAS  PubMed  Google Scholar 

  4. Choo R, Thomas G, Woo T, et al. Long-term outcome of postorchidectomy surveillance for stage I testicular seminoma. Int J Radiat Oncol Biol Phys 2005;61(3): 736–740.

    PubMed  Google Scholar 

  5. Fossa SD. Long-term sequelae after cancer therapy—survivorship after treatment for testicular cancer. Acta Oncol 2004;43(2):134–141.

    Article  PubMed  Google Scholar 

  6. Huddart RA, Norman A, Shahidi M, et al. Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol 2003;21(8):1513–1523.

    Article  CAS  PubMed  Google Scholar 

  7. Travis LB, Fossa SD, Schonfeld SJ, et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005;97:1354–1365.

    Article  PubMed  Google Scholar 

  8. Oliver RT, Mason MD, Mead GM, et al. Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet 2005; 366(9482):293–300.

    Article  CAS  PubMed  Google Scholar 

  9. Schmoll HJ, Souchon R, Krege S, et al. European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004;15(9):1377–1399.

    Article  CAS  PubMed  Google Scholar 

  10. Fossa SD, Horwich A, Russell JM, et al. Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. J Clin Oncol 1999; 17(4): 1146.

    CAS  PubMed  Google Scholar 

  11. Jones WG, Fossa SD, Mead GM, et al. Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: a report on Medical Research Council Trial TE 18, European Organization for the Research and Treatment of Cancer Trial 30942 (ISRCTN 18525328). J Clin Oncol 2005;23(6):1200–1208.

    Article  PubMed  Google Scholar 

  12. Chung PW, Warde PR, Panzarella T, et al. Appropriate radiation volume for stage IIA/B testicular seminoma. Int J Radiat Oncol Biol Phys 2003;56(3):746–748.

    PubMed  Google Scholar 

  13. Patterson H, Norman AR, Mitra SS, et al. Combination carboplatin and radiotherapy in the management of stage II testicular seminoma: comparison with radiotherapy treatment alone. Radiother Oncol 2001;59(1):5–11.

    Article  CAS  PubMed  Google Scholar 

  14. Gunar K. Zagars, Matthew T, et al. Mortality after cure of testicular seminoma. J Clin Oncol 2004;22(4):640–647.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cell Therapy and Oncology, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway

    Dag Josefsen MD, PhD

  2. Unit for Long Term Studies of Cancer Patients Clinical Cancer Research, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway

    Sophie D. Fosså MD, PhD

Authors
  1. Dag Josefsen MD, PhD
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  2. Sophie D. Fosså MD, PhD
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Editor information

Editors and Affiliations

  1. St. Bartholomew’s and Homerton Hospitals Queen Mary Barts and the London School of Medicine and Dentistry, University of London, London, UK

    Vinod H. Nargund PhD, FRCS (Urol), FEBU (Chair, Uro-Oncology MDT and Consultant Urological Surgeon) (Chair, Uro-Oncology MDT and Consultant Urological Surgeon)

  2. Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA

    Derek Raghavan MD, PhD, FACP, FRACP (Chairman and Director) (Chairman and Director)

  3. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA

    Howard M. Sandler MD (Professor and Senior Associate Chair) (Professor and Senior Associate Chair)

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© 2008 Springer-Verlag London Limited

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Josefsen, D., Fosså, S.D. (2008). Radiotherapy in the Management of Testicular Germ Cell Tumors. In: Nargund, V.H., Raghavan, D., Sandler, H.M. (eds) Urological Oncology. Springer, London. https://doi.org/10.1007/978-1-84628-738-1_24

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  • DOI: https://doi.org/10.1007/978-1-84628-738-1_24

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-387-1

  • Online ISBN: 978-1-84628-738-1

  • eBook Packages: MedicineMedicine (R0)

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