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Genetics of Osteoporosis in Older Age

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Osteoporosis in Older Persons

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Osteoporosis results from a failure to acquire optimal peak bone mass during growth (1) and/or to maintain bone mass in later years. There are two backgrounds for the pathophysiology of invo-lutional osteoporosis: a rapid bone loss after menopause as a result of estrogen withdrawal, and a gradual age-related bone loss thereafter. Women experience a more rapid phase of bone loss after the menopause, caused mainly by estrogen deficiency (2,3), but a less rapid bone loss persists in older persons, in both men and women (4,5). Some authors thus distinguish between two types of pathophysiology of osteoporosis: menopausal and age-related (“senile.”). Bone health in old age depends on a susceptibility to osteoporotic fractures, which seems to be dependent on genetic factors (heritable). The genetic contribution to involutional osteoporosis is substantial and has been extensively studied. With recent advances in the elucidation of the mechanisms involved in osteoporosis, there is a recognition that the two types of syndromes may have different genetic components. Genetic contributions to fractures and fragility in elderly persons in comparison with younger individuals distinguish age-related osteoporosis.

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Authors and Affiliations

  1. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA

    David Karasik PhD

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  1. David Karasik PhD
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  2. Douglas P. Kiel MD, MPH
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  1. Division of Geriatric Medicine-Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada

    Gustavo Duque

  2. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA

    Douglas P. Kiel

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Karasik, D., Kiel, D.P. (2009). Genetics of Osteoporosis in Older Age. In: Duque, G., Kiel, D.P. (eds) Osteoporosis in Older Persons. Springer, London. https://doi.org/10.1007/978-1-84628-697-1_7

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  • DOI: https://doi.org/10.1007/978-1-84628-697-1_7

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