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Biology of Bone

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Osteoporosis in Older Persons

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Bone is an exquisitely sophisticated organ/tissue in mammals. Bone is generally viewed as the main component of the skeleton, providing mechanical and structural support to the rest of the organs and systems. This function is indispensable for life, both during the growth and development period as well as during adult life. However, bone also provides the unique architecture and microenvironment that preserves the niches that maintain immature stem cells. This inadequately recognized function is also essential, because these stem cells are required for tissue repair and regeneration during adult life. In this respect, besides providing mechanical support, bone holds and supports the main reservoir of cells needed to sustain tissue integrity and function throughout our lives. Thus, understanding how bone is made and maintained during life is central to developing adequate strategies to preserve a healthy skeleton as we age; so that proper mechanical support, structural integrity, and tissue repair capacity is maintained.

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Authors and Affiliations

  1. University of Miami Miller School of Medicine and Geriatric Research, Educational and Clinical Center and Research Service, Veterans Affairs Medical Center, Miami, FL, USA

    Paul C. Schiller PhD (Associate Professor), Gianluca D'Ippolito PhD (Assistant Professor) & Guy A. Howard PhD (Professor)

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  1. Paul C. Schiller PhD
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  2. Gianluca D'Ippolito PhD
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  3. Guy A. Howard PhD
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Editors and Affiliations

  1. Division of Geriatric Medicine-Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada

    Gustavo Duque

  2. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA

    Douglas P. Kiel

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© 2009 Springer-Verlag London Limited

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Schiller, P.C., D'Ippolito, G., Howard, G.A. (2009). Biology of Bone. In: Duque, G., Kiel, D.P. (eds) Osteoporosis in Older Persons. Springer, London. https://doi.org/10.1007/978-1-84628-697-1_1

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  • DOI: https://doi.org/10.1007/978-1-84628-697-1_1

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-515-8

  • Online ISBN: 978-1-84628-697-1

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