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Urological Cancers in Clinical Practice pp 161–186Cite as

Novel Therapies for Renal Cell Cancer

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Abstract

The discovery of diverse details of the genetics, cell biology, and pathology of disease and the extensive infrastructure for synthesis and testing of targeted drugs or immune strategies are a basis to be hopeful that innovative, effective, widely applicable therapies can be realized for metastatic kidney cancer. High-dose interleukin-2 had been the sole medical therapy approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic renal cancer, and interferon-a, also in widespread use, has had approval in Europe. More than 100 published single-arm/single-drug kidney cancer trials, many based on sound preclinical hypotheses, would seem to be a basis for pessimism. Partial response and disease stabilization at high frequency led to the approval of sorafenib and sunitinib. Whereas progress in conventional cytotoxics has largely bypassed renal cancer, and immune therapies have had dramatic success limited to a minority of patients, some therapies may turn out to be broadly tolerated and efficacious. This is an era for optimism for the application of new technology to kidney cancer therapy.

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  1. Genitourinary Oncology & Experimental Therapeutics Department of Interdisciplinary Oncology H. Lee Mofitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA

    Mayer N. Fishman MD, PhD

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  1. Mayer N. Fishman MD, PhD
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  1. Department of Oncology, Division of Surgery, Oncology Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, The Garry Weston Centre, Hammersmith Hospital, London, UK

    Jonathan Waxman BSc, MD, FRCP (Professor of Oncology) (Professor of Oncology)

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Fishman, M.N. (2007). Novel Therapies for Renal Cell Cancer. In: Waxman, J. (eds) Urological Cancers in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-84628-507-3_8

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