Abstract
Colorectal cancer (CRC) is the second most common cause of death from cancer in both the UK and the US. The incidence increases with age, and the disease is much more common in Western industrialized countries that have a high-fat, low-fiber diet. In most cases, CRC develops over a period of years in a preexisting adenomatous polyp (the “adenoma-carcinoma sequence”). Knowledge of this pathway has led to the development of screening programs using colonoscopy or barium enema. The size of the polyp determines the risk of malignant change; only a small percentage of polyps will develop into cancers. Those less than 1cm have less than a 1% chance of containing malignant cells, whereas half of those over 2cm are malignant. Approximately 3% of patients with colorectal cancer will have a second or synchronous tumor at the time of presentation.
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© 2007 Springer-Verlag London Limited
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Clarke, J. (2007). Colorectal Cancer. In: PET/CT in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-84628-504-2_5
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DOI: https://doi.org/10.1007/978-1-84628-504-2_5
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