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New Perspectives in Magnesium Research pp 316–329Cite as

Magesium in Hemodialysis Patients

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Abstract

Magnesium (Mg) is the second most abundant intracellular cation and the fourth most abundant cation of the human body. Magnesium plays an essential role as a cofactor for a variety of enzymes, including those involved in several key steps of intermediary metabolism and phosphorylation. In addition, Mg is required for protein and nucleic acid synthesis, the cell cycle progression, cytoskeletal and mitochondrial integrity, and the binding of substances to the plasma membrane. Disorders of Mg homeostasis may lead to profound changes in the function and well being of the organism. Serum Mg concentration is normal in patients with early renal failure, but hypermagnesemia usually occurs in the advanced stage of renal failure due to the reduced urinary Mg excretion. Following the introduction of chronic hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) treatment, the major factor to determine Mg balance is Mg levels in the dialysate. Patients with end-stage renal disease (ESRD) who are receiving dialysis may develop various complications including hypertension, atherosclerosis, dyslipidemia, and renal osteodystrophy. The disturbance of Mg balance in those patients maintained on dialysis may affect the development of these complications.

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Author information

Authors and Affiliations

  1. Kidney Center Shirasagi Clinic, Osaka, Japan

    Senji Okuno MD, PhD

  2. Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

    Masaaki Inaba MD, PhD

Authors
  1. Senji Okuno MD, PhD
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  2. Masaaki Inaba MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

    Yoshiki Nishizawa MD, PhD (Dean of Medicine, Professor of Internal Medicine) (Dean of Medicine, Professor of Internal Medicine)

  2. Osaka City University, Osaka, Japan

    Hirotoshi Morii MD, PhD (Emeritus Professor) (Emeritus Professor)

  3. Université Pierre et Marie Curie, Paris, France

    Jean Durlach MD, PhD (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal) (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal)

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© 2007 Springer-Verlag London Limited

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Okuno, S., Inaba, M. (2007). Magesium in Hemodialysis Patients. In: Nishizawa, Y., Morii, H., Durlach, J. (eds) New Perspectives in Magnesium Research. Springer, London. https://doi.org/10.1007/978-1-84628-483-0_26

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  • DOI: https://doi.org/10.1007/978-1-84628-483-0_26

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-388-8

  • Online ISBN: 978-1-84628-483-0

  • eBook Packages: MedicineMedicine (R0)

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