Increased ectopic ventricular complex (EVC) activity has been conceptually considered as one of the possible triggering mechanisms associated with an increased risk of malignant ventricular arrhythmias.


Ventricular Arrhythmia Cardiovascular Health Study Coronary Heart Disease Death Right Bundle Branch Block Multiple Risk Factor Intervention Trial 
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  1. 1.
    Cranefied PF, Aronson RS. Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms. Mount Kisco, New York: Futura Publishing Company, 1988, p. 420.Google Scholar
  2. 2.
    Janse MJ, van Capelle FJ, Morsink H et al. Flow of “injury” current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms. Circulation Res 1980;47:151–65.PubMedGoogle Scholar
  3. 3.
    Janse MJ, Kleber AG. Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia. Circulation Res 1981;49:1069–81.PubMedGoogle Scholar
  4. 4.
    Janse MJ, van Capelle FJ. Electrotonic interactions across an inexcitable region as a cause of ectopic activity in acute myocardial ischemia. A study in porcine and canine hearts and computer models. Circulation Res 1982;50:527–37.PubMedGoogle Scholar
  5. 5.
    Pratt CM, Slymen DJ, Wierman AM et al. Analysis of the spontaneous variability of ventricular arrhythmias: consecutive ambulatory electrocardiographic recording of ventricular tachycardia. Am J Cardiol 1985;56:67–72.PubMedCrossRefGoogle Scholar
  6. 6.
    Toivonen L. Spontaneous variability in the frequency of ventricular premature complexes over prolonged intervals and implications for antiarrhythmic treatment. Am J Cardiol 1987;60:608–12.PubMedCrossRefGoogle Scholar
  7. 7.
    Sami M, Kraemer H, Harrison DC et al. A new method for evaluating antiarrhythmic drug efficacy. Circulation 1980;62:1172–9.PubMedGoogle Scholar
  8. 8.
    Anderson JL, Karagounis LA, Stein KM et al. Predictive value for future arrhythmic events of fractal dimension, a measure of time clustering of ventricular premature complexes, after myocardial infarction. J Am Coll Cardiol 1997;30:226–32.PubMedCrossRefGoogle Scholar
  9. 9.
    Stein KM, Karagounis LA, Anderson JL et al. Fractal clustering of ventricular ectopy correlates with sympathetic tone preceding ectopic beats. Circulation 1995;91:722–7.PubMedGoogle Scholar
  10. 10.
    Huikuri HV, Valkama JO, Airaksinen KE et al. Frequency domain measures of heart rate variability before the onset of nonsustained and sustained ventricular tachycardia in patients with coronary artery disease. Circulation 1993;87:1220–8.PubMedGoogle Scholar
  11. 11.
    Lown B, Wolf M. Approaches to sudden death from coronary heart disease. Circulation 1971;44:130–42.PubMedGoogle Scholar
  12. 12.
    Kostis JB, Byington R, Friedman LM et al. Prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction. J Am Coll Cardiol 1987;10:231–42.PubMedGoogle Scholar
  13. 13.
    Bigger JT, Feld FM. Analysis of prognostic significance of ventricular arrhythmias after myocardial infarction. Shortcomings of Lown grading system. Br Heart J 1981;45:717–24.PubMedGoogle Scholar
  14. 14.
    Reunanen A, Aromaa A, Pyõrãlã K et al. The Social Insurance Institution’s Heart Disease Study. Baseline data and 5-year mortality experience. Acta Med Scand 1983;673(Suppl):1–109.Google Scholar
  15. 15.
    Simpson RJ, Cascio WE, Schreiner PJ et al. Prevalence of premature ventricular contractions in a population of African American and white men and women: the Atherosclerosis in Communities (ARIC) study. Am Heart J 2002;143:535–40.PubMedCrossRefGoogle Scholar
  16. 16.
    Crow RS, Prineas RJ, Dias V et al. Ventricular premature beats in a population sample. Frequency and associations with coronary risk characteristics. Circulation 1975;52(Suppl III):211–5.Google Scholar
  17. 17.
    Koren MJ, Mensah GA, Blake J et al. Comparison of left ventricular mass and geometry in black and white patients with essential hypertension. Am J Hypertens 1993;6:815–23.PubMedGoogle Scholar
  18. 18.
    Bikkina M, Larson MG, Levy D. Prognostic implications of asymptomatic ventricular arrhythmias: the Framingham Study. Ann Intern Med 1992;117:990–6.PubMedGoogle Scholar
  19. 19.
    Romhilt DW, Chaffin C, Sung CC, Irby EC. Arrhythmias on ambulatory electrocardiographic monitoring in women without apparent heart disease. Am J Cardiol 1984;54:582–6.PubMedCrossRefGoogle Scholar
  20. 20.
    Manolio TA, Furberg CD, Rautaharju PM et al. Cardiac arrhythmias on 24-h ambulatory electrocardiography on older women and men: the Cardiovascular Health Study. J Am Coll Cardiol 1994;23:916–25.PubMedGoogle Scholar
  21. 21.
    Rautaharju PM, Manolio TA, Psaty BM et al. Correlates of QT prolongation in older adults (the Cardiovascular Health Study). Am J Cardiol 1994;73:999–1002.PubMedCrossRefGoogle Scholar
  22. 22.
    Camm AJ, Evans KE, Ward DE, Martin A. The rhythm of the heart in active elderly subjects. Am Heart J 1980;99:598–603.PubMedCrossRefGoogle Scholar
  23. 23.
    Fleg JL, Kennedy HL. Cardiac arrhythmias in a healthy elderly population. Chest 1982;81:302–7.PubMedGoogle Scholar
  24. 24.
    Byington RP. Beta-blocker Heart Attack Trial: design, methods, and baseline results. Beta-blocker Heart Attack Trial research group. Control Clin Trials 1984;5:382–437.PubMedCrossRefGoogle Scholar
  25. 25.
    Lichstein E, Morganroth J, Harris R, Hubble E. Effect of propranolol on ventricular arrhythmia. The Beta-blocker Heart Attack Trial experience. Circulation 1983;67:5–10.Google Scholar
  26. 26.
    Kuch KH, Costard A, Schluter M, Kunze KP. Significance of timing programmed electrical stimulation after acute myocardial infarction. J Am Coll Cardiol 1986;8:1279–88.Google Scholar
  27. 27.
    Goldstein S, Zoble RG, Akiyama T et al. Relation of circadian ventricular ectopic activity to cardiac mortality. CAST investigators. Am J Cardiol 1996;78:881–5.PubMedCrossRefGoogle Scholar
  28. 28.
    Simpson RJ Jr, Cascio WE, Crow RS et al. Association of ventricular premature complexes with electrocardiographic-estimated left ventricular mass in a population of African-American and white men and women (the Atherosclerosis Risk in Communities study). Am J Cardiol 2001;87:49–53.PubMedCrossRefGoogle Scholar
  29. 29.
    Bikkina M, Larson MG, Levy D. Asymptomatic ventricular arrhythmias and mortality risk in subjects with left ventricular hypertrophy. J Am Coll Cardiol 1993;22:1111–6.PubMedCrossRefGoogle Scholar
  30. 30.
    Kotler MN, Tabatznik B, Mower MM, Tominaga S. Prognostic significance of ventricular ectopic beats with respect to sudden death in the late postinfarction period. Circulation 1973;47:959–66.PubMedGoogle Scholar
  31. 31.
    Ruberman W, Weinblatt E, Goldberg J et al. Ventricular premature beats and mortality after myocardial infarction. N Engl J Med 1977;297:750–7.PubMedCrossRefGoogle Scholar
  32. 32.
    Moss AJ, Davis HT, DeCamilla J, Bayer LW. Ventricular ectopic beats and their relation to sudden and nonsudden death after myocardial infarction. Circulation 1979;60:998–1003.PubMedGoogle Scholar
  33. 33.
    Mukharji J, Rude RE, Poole WK et al. Risk factors for sudden death after acute myocardial infarction: two-year follow-up. Am J Cardiol 1984;54:31–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Bigger JT Jr, Fleiss JL, Kleiger R et al. The relationship among ventricular arrhythmias, left ventricular dysfunction, and mortality in the two years after myocardial infarction. Circulation 1984;69:250–7.PubMedGoogle Scholar
  35. 35.
    Maisel AS, Scott N, Gilpin E et al. Complex ventricular arrhythmias in patients with Q wave versus non-Q wave myocardial infarction. Circulation 1985;72:963–70.PubMedGoogle Scholar
  36. 36.
    Kostis JB, Wilson AC, Sanders MR, Buyington RP. Prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction who receive propranolol. Am J Cardiol 1988;61:975–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Denes P, Gillis AM, Pawitan Y et al. Prevalence, characteristics and significance of ventricular premature complexes and ventricular tachycardia detected by 24-hour continuous electrocardiographic recording in the Cardiac Arrhythmia Suppression Trial. CAST investigators. Am J Cardiol 1991;68:887–96.PubMedCrossRefGoogle Scholar
  38. 38.
    The Cardiac Arrhythmia Suppression Trial (CAST) investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1989;321:406–12.Google Scholar
  39. 39.
    Hjalmarson A. Metoprolol in Acute Myocardial Infarction (MIAMI). Am J Cardiol 1985;56:1G–46G.CrossRefGoogle Scholar
  40. 40.
    Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. Lancet 1986;2:57–66.Google Scholar
  41. 41.
    Norris RM, Barnaby PF, Brown MA, Geary GG, Clarke ED, Logan RL, Sharpe DN. Prevention of ventricular fibrillation during acute myocardial infarction by intravenous propranolol. Lancet 1984;2:883–6.PubMedCrossRefGoogle Scholar
  42. 42.
    Ryden L, Ariniego R, Arnman K et al. A doubleblind trial of metoprolol in acute myocardial infarction. Effects on ventricular tachyarrhythmias. N Engl J Med 1983;308:614–8.PubMedCrossRefGoogle Scholar
  43. 43.
    Olsson G, Rehnquist N. Treatment of ventricular arrhythmias in the coronary patient: what sort of patient? For which rhythm disorder? With what procedure? Am J Cardiol 1989;64:57J–60J.PubMedCrossRefGoogle Scholar

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