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Abstract

High resting heart rate (HR) is in generally considered as a nonspecific indicator of poor health. Reduced HR variability (HRV) has been associated in numerous studies with mortality risk.

Keywords

Heart Rate Variability High Frequency Power Heart Rate Variability Measure Reduce Heart Rate Variability Heart Rate Variability Variable 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rautaharju PM, Zhou SH, Calhoun HP, Spodick DH. Distribution of sinus heart rates in community-based populations. In: Macfarlane PW, Rautaharju P (eds). Electrocardiology’ 93. XXth International Congress on Electrocardiology, 1993. Singapore: World Scientific Publishing Co. Pte. Ltd, 1994, pp 265–8.Google Scholar
  2. 2.
    Palatini P. Need for a revision of the normal limits of resting heart rate. Hypertension 1999;33:622–5.PubMedGoogle Scholar
  3. 3.
    Boyett MR, Jewell BR. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog Biophys Molec Biol 1980;36:1–52.CrossRefGoogle Scholar
  4. 4.
    Cohen I, Giles WR, Noble D. Cellular basis for the T wave of the electrocardiogram. Nature 1976;262:657–61.PubMedCrossRefGoogle Scholar
  5. 5.
    Antzelovitch C, Zygmunt AC, Dumaine R. Electrophysiology and pharmacology of ventricular repolarization. In: Gussak I, Antzelovitch C (eds). Cardiac Repolarization. Bridging Basic and Clinical Science. Totowa, New Jersey: Humana Press, 2003, pp 63–89.Google Scholar
  6. 6.
    Nobel D, Cohen I. The interpretation of the T wave of the electrocardiogram. Cardiovasc Res 1978;12:13–27.CrossRefGoogle Scholar
  7. 7.
    Azbel MY. Universal biological scaling and mortality. Proc Natl Acad Sci USA 1994;91:12453–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Levin HJ. Rest heart rate and life expectancy. J Am Coll Cardiol 1997;30:1104–6.CrossRefGoogle Scholar
  9. 9.
    Medalie JH, Kahn HA, Neufeld HN. Five-year myocardial infarction incidence. II. Associations of single variables to age and birthplace. J Chron Dis 1973;26:329–49.CrossRefGoogle Scholar
  10. 10.
    Schroll M, Hangerup LM. Risk factors of myocardial infarction and death in men aged 50 at entry. A ten-year prospective study from the Glostrup Population Studies. Dan Med Bull 1977;24:252–5.PubMedGoogle Scholar
  11. 11.
    Eriksen J, Rodahl K. Resting heart rate in apparently healthy middle-aged men. Eur J Appl Physiol 1979;42:61–9.CrossRefGoogle Scholar
  12. 12.
    Dyer AR, Persky V, Stamler J et al. Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiological studies. Am J Epidemiol 1980;112:736–49.PubMedGoogle Scholar
  13. 13.
    Kannel WB, Kannel C, Paffenbarger RS, Cupples LA. Heart rate and cardiovascular mortality: The Framingham Study. Am Heart J 1987;113:1489–94.PubMedCrossRefGoogle Scholar
  14. 14.
    Gillum RF, Makuc DM, Feldman JJ. Pulse rate, coronary heart disease, and death: the NHANES I Epidemiologic Follow-Up Study. Am Heart J 1991;121:172–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Reunanen A, Karjalainen J, Ristola P et al. Heart rate and mortality. J Intern Med 2000;247:231–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Benetos A, Rudnichi A, Thomas F et al. Influence of heart rate on mortality in a French population: role of age, gender, and blood pressure. Hypertension 1999;33:44–52.PubMedGoogle Scholar
  17. 17.
    Greenland P, Daviglus ML, Dyer AR et al. Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry. Am J Epidemiol 1999;149:853–62.PubMedGoogle Scholar
  18. 18.
    Palatini P, Thijs L, Staessen JA et al. Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. Arch Intern Med 2002;162:2313–21.PubMedCrossRefGoogle Scholar
  19. 19.
    Fujiura Y, Adachi H, Tsuruta M et al. Heart rate and mortality in a Japanese general population: an 18-year follow-up study. J Clin Epidemiol 2001;54:495–500.PubMedCrossRefGoogle Scholar
  20. 20.
    Seccareccia F, Pannozzo F, Dima F et al. Heart rate as a predictor of mortality: the MATISS project. Am J Public Health 2001;91:1258–63.PubMedGoogle Scholar
  21. 21.
    Zuanetti G, Mantini L, Hernandez-Bernal F et al. Relevance of heart rate as a prognostic factor in patients with acute myocardial infarction: insights from the GISSI-2 study. Eur Heart J 1998:19(Suppl F):F19–F26.PubMedGoogle Scholar
  22. 22.
    Perski A, Olsson G, Landou C et al. Minimum heart rate and coronary atherosclerosis: independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age. Am Heart J 1992;123:609–16.PubMedCrossRefGoogle Scholar
  23. 23.
    Chaitman BR. Abnormal heart rate responses to exercise predict increased long-term mortality regardless of coronary disease extent: the question why? J Am Coll Cardiol 2003;42:839–41.PubMedCrossRefGoogle Scholar
  24. 24.
    Cole CR, Blackstone EH, Pashkow F et al. Heartrate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999;341:1351–7.PubMedCrossRefGoogle Scholar
  25. 25.
    Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med 2000;132:552–5.PubMedGoogle Scholar
  26. 26.
    Vivekananthan DP, Blackstone EH, Pothier CE et al. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol 2003;42:831–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Bigger JT, Fleiss JL, Rolnitzky LM, Steinman RC. The ability of several short-term measures of RR variability to predict mortality after myocardial infarction. Circulation 1993;88:927–34.PubMedGoogle Scholar
  28. 28.
    Bigger JT Jr, Fleiss JL, Steinman RC et al. Correlations among time and frequency-domain measures of heart period variability two weeks after acute myocardial infarction. Am J Cardiol 1992;69:891–8.PubMedCrossRefGoogle Scholar
  29. 29.
    Umetani K, Singer DH, McCraty R, Atkinson M. Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 1998;31:593–601.PubMedCrossRefGoogle Scholar
  30. 30.
    Tsuji H, Venditti FJ, Manders ES et al. Determinants of heart rate variability. J Am Coll Cardiol 1996;28:1539–46.PubMedCrossRefGoogle Scholar
  31. 31.
    Pikkujãmsã S. Heart rate variability and baroreflex sensitivity in subjects without heart disease. MD thesis, University of Oulu, Finland. Oulu University Library, 1999.Google Scholar
  32. 32.
    Abdel-Rahman AR, Merrill RH, Wooles WR. Gender-related differences in the baroreceptor reflex control of heart rate in normotensive humans. J Appl Physiol 1994;77:606–13.PubMedGoogle Scholar
  33. 33.
    Liao D, Barnes RW, Chambless LE et al. Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability — the ARIC study. Atherosclerosis Risk in Communities. Am J Cardiol 1995;76:906–12.PubMedCrossRefGoogle Scholar
  34. 34.
    Huikuri HV, Pikkujãmsã SM, Airaksinen KEJ et al. Sex-related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation1996;94:122–5.PubMedGoogle Scholar
  35. 35.
    Huikuri HV, Kessler KM, Terracall E et al. Reproducibility and circadian rhythm of heart rate variability in healthy subjects. Am J Cardiol 1990;65:391–3.PubMedCrossRefGoogle Scholar
  36. 36.
    Niemelã MJ, Airaksinen KEJ, Huikuri HV. Effect of beta-blockade on heart rate variability in patients with coronary artery disease. J Am Coll Cardiol 1994;23:1370–7.PubMedGoogle Scholar
  37. 37.
    Kamath MV, Fallen E. Diurnal variation of neurocardiac rhythms in acute myocardial infarction. Am J Cardiol 1991;68:155–60.PubMedCrossRefGoogle Scholar
  38. 38.
    Cook JR, Bigger JT Jr, Kleiger RE et al. Effect of atenolol and diltiazem on heart period variability in normal persons. J Am Coll Cardiol 1991;17:480–4.PubMedGoogle Scholar
  39. 39.
    Beta-Blocker Heart Attack Research Group. A randomized trial of propranolol in patients with acute myocardial infarction. JAMA 1982;247:1707–14.CrossRefGoogle Scholar
  40. 40.
    Lampert R, Ickovics JR, Viscoli CJ et al. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. Am J Cardiol 2003;91:137–42.PubMedCrossRefGoogle Scholar
  41. 41.
    Bigger JT, Fleiss SL, Steinman RC et al. RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction. Circulation 1995;91:1936–43.PubMedGoogle Scholar
  42. 42.
    Bigger JT Jr, Fleiss JL, Rolnitzky LM. Time course of recovery of heart period variability after myocardial infarction. J Am Coll Cardiol 1991;18:1643–9.PubMedGoogle Scholar
  43. 43.
    Casolo GC, Stroder P, Signorini C et al. Heart rate variability during the acute phase of myocardial infarction. Circulation 1992;85:2073–9.PubMedGoogle Scholar
  44. 44.
    Lombardi F, Sandrone G, Pernpruder S et al. Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction. Am J Cardiol 1987;60:1239–45.PubMedCrossRefGoogle Scholar
  45. 45.
    Liao D, Evans GW, Chambless LE et al. Populationbased study of heart rate variability and prevalent myocardial infarction. The Atherosclerosis Risk in Communities Study. J Electrocardiol 1996;29:189–98.PubMedCrossRefGoogle Scholar
  46. 46.
    Malik M, Farrelli T, Camm AJ. Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability. Am J Cardiol 1990;66:1049–54.PubMedCrossRefGoogle Scholar
  47. 47.
    Huikuri HV, Niemelã MJ, Ojala S et al. Circadian rhythm of frequency domain measures of heart rate variability in healthy subjects and patients with coronary artery disease: effects of arousal and upright posture. Circulation 1994;90:121–6.PubMedGoogle Scholar
  48. 48.
    Lombardi F, Sandrone G, Mortara A et al. Circadian variation of spectral indices of heart rate variability after myocardial infarction. Am Heart J 1992;123:1521–9.PubMedCrossRefGoogle Scholar
  49. 49.
    Vanoli E, Adamson PB, Ba-Lin et al. Heart rate variability during specific sleep stages. A comparison of healthy subjects with patients after myocardial infarction. Circulation 1995;91:1918–22.PubMedGoogle Scholar
  50. 50.
    Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 1996;93:1043–65.Google Scholar
  51. 51.
    Langewitz W, Ruddel H, Schachinger H. Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress. Am Heart J 1994;127:122–8.PubMedCrossRefGoogle Scholar
  52. 52.
    Guzzetti S, Dassi S, Pecis M et al. Altered pattern of circadian neural control of heart period in mild hypertension. J Hypertens 1991;9:831–8.PubMedCrossRefGoogle Scholar
  53. 53.
    Kienzle MG, Ferguson DW, Birkett CL et al. Clinical hemodynamic and sympathetic neural correlates of heart rate variability in congestive heart failure. Am J Cardiol 1992;69:482–5.CrossRefGoogle Scholar
  54. 54.
    Casolo G, Balli E, Taddei T et al. Decreased spontaneous heart rate variability in congestive heart failure. Am J Cardiol 1989;64:1162–7.PubMedCrossRefGoogle Scholar
  55. 55.
    Saul JP, Arai Y, Berger RD et al. Assessment of autonomic regulation in chronic congestive heart failure by the heart rate spectral analysis. Am J Cardiol 1988;61:1292–9.PubMedCrossRefGoogle Scholar
  56. 56.
    Binkley PF, Nunziata E, Haas GJ et al. Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model of ventricular failure. J Am Coll Cardiol 1991;18:464–2.PubMedGoogle Scholar
  57. 57.
    Townend JN, West JN, Davies MK et al. Effect of quinapril on blood pressure and heart rate in congestive heart failure. Am J Cardiol 1992;69:1587–90.PubMedCrossRefGoogle Scholar
  58. 58.
    Tsuji H, Larson MG, Venditti FJ et al. Impact of reduced heart rate variability on risk for cardiac events. Circulation 1996;94:2850–5.PubMedGoogle Scholar
  59. 59.
    Tsuji H, Venditti FJ, Manders ES et al. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Study. Circulation 1994;90:878–83.PubMedGoogle Scholar
  60. 60.
    Liao D, Cai J, Rosamond WD et al. Cardiac autonomic function and incident coronary heart disease: a population-based case-cohort study. The ARIC Study. Am J Epidemiol 1997;145:696–706.PubMedGoogle Scholar
  61. 61.
    de Bruyne MC, Kors JA, Hoes AW et al. Both decreased and increased heart rate variability on the standard 10-second electrocardiogram predict cardiac mortality in the elderly: the Rotterdam Study. Am J Epidemiol 1999;15:1282–8.Google Scholar
  62. 62.
    Dekker JM, Crow RS, Folsom AR et al. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis Risk in Communities. Circulation 2000;102:1239–44.PubMedGoogle Scholar
  63. 63.
    Liao D, Carnethon M, Evans GW et al. Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes 2002;51:3524–31.PubMedCrossRefGoogle Scholar
  64. 64.
    Huikuri HV, Mãkikallio TH, Airaksinen KEJ et al. Power-law relationship of heart rate variability as a predictor of mortality in the elderly. Circulation 1998;97:2031–6.PubMedGoogle Scholar
  65. 65.
    Dekker JM, Schouten EG, Klootwijk P et al. Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am J Epidemiol 1997;145:899–908.PubMedGoogle Scholar
  66. 66.
    Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256–62PubMedCrossRefGoogle Scholar
  67. 67.
    Hartikainen J, Malik M, Staunton A et al. Distinction between arrhythmic and nonarrhythmic death after acute myocardial infarction based on heart rate variability, signal-averaged electrocardiogram, ventricular arrhythmias and left ventricular ejection fraction. J Am Coll Cardiol 1996;28:296–304.PubMedCrossRefGoogle Scholar
  68. 68.
    Bigger JT Jr, Fleiss JL et al. Frequency domain measures of heart period variability to assess risk late after myocardial infarction. J Am Coll Cardiol 1993;21:729–36.PubMedCrossRefGoogle Scholar
  69. 69.
    Bigger JT Jr, Fleiss JL, Steinman RC et al. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 1992;85:164–71.PubMedGoogle Scholar
  70. 70.
    La Rovere M, Bigger J Jr, Marcus F et al. Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) investigators. Lancet 1998;351:478–84.PubMedCrossRefGoogle Scholar
  71. 71.
    Zuanetti G, Neilson JMM, Latini R et al. Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era. Circulation 1996;94:432–6.PubMedGoogle Scholar
  72. 72.
    Tapanainen JM, Bloch Thomsen PE, Køber L et al. Fractal analysis of heart rate variability and mortality after an acute myocardial infarction. Am J Cardiol 2002;90:347–52.PubMedCrossRefGoogle Scholar
  73. 73.
    Tapanainen J. Non-invasive predictors of mortality after acute myocardial infarction. MD Thesis, University of Oulu, Finland, 2003.Google Scholar
  74. 74.
    Tapanainen JM, Still AM, Airaksinen KEJ, Huikuri HV. Prognostic significance of risk stratifiers of mortality, including T wave alternans, after acute myocardial infarction: results of a prospective follow-up study. J Cardiovasc Electrophysiol 2001;12:645–53.PubMedCrossRefGoogle Scholar
  75. 75.
    Mãkikallio TH, Sepp~anen T, Niemelã M et al. Abnormalities in beat to beat complexity of heart rate dynamics in patients with a previous myocardial infarction. J Am Coll Cardiol 1996;28:1005–11.PubMedCrossRefGoogle Scholar

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