Skip to main content

Celiac Lymph Nodes and Esophageal Cancer

  • Chapter
Difficult Decisions in Thoracic Surgery

Abstract

Celiac lymph nodes are considered a distant metastatic site (M1) in esophageal cancer. The M1a subclassification is recommended for distal thoracic esophageal cancer metastatic to celiac lymph nodes. This suggests that although these cancers are beyond cure, they are different from esophageal cancers with other sites of distant metastases (M1b). Of 46 disease sites for which the American Joint Committee on Cancer (AJCC) has staging recommendations, only 7 (15%) require subdivision of M1: 2 with 3 subclassifications (M1a, M1b and M1c) — cutaneous melanoma and prostate; and 5 with 2 subclassifications (M1a and M1b) — bone, retinoblastoma, testis, gestational trophoblastic tumor, and esophagus. Only prostate, testis, and esophagus designate nonregional nodes as M1a.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. AJCC Cancer Staging Manual. 6th ed. New York: Springer; 2002.

    Google Scholar 

  2. Clark GW, Peters JH, Ireland AP, et al. Nodal metastasis and sites of recurrence after en bloc esophagectomy for adenocarcinoma. Ann Thorac Surg 1994;58:646–653; discussion 53–54.

    Article  PubMed  CAS  Google Scholar 

  3. Fujita H, Kakegawa T, Yamana H, et al. Lymph node metastasis and recurrence in patients with a carcinoma of the thoracic esophagus who underwent three-field dissection. World J Surg 1994;18: 266–272.

    Article  PubMed  CAS  Google Scholar 

  4. Hulscher JB, Buskens CJ, Bergman JJ, Fockens P, Van Lanschot JJ, Obertop H. Positive peritruncal nodes for esophageal carcinoma. not always a dismal prognosis. Dig Surg 2001;18:98–101.

    Article  PubMed  CAS  Google Scholar 

  5. Akiyama H, Tsurumaru M, Udagawa H, Kajiyama Y. Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 1994;220:364–372; discussion 72–73.

    Article  PubMed  CAS  Google Scholar 

  6. Hagen JA, DeMeester SR, Peters JH, Chandrasoma P, DeMeester TR. Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies. Ann Surg 2001;234:520–530; discussion 30–31.

    Article  PubMed  CAS  Google Scholar 

  7. Hulscher JB, Van Sandick JW, Offerhaus GJ, Tilanus HW, Obertop H, Van Lanschot JJ. Prospective analysis of the diagnostic yield of extended en bloc resection for adenocarcinoma of the oesophagus or gastric cardia. Br J Surg 2001;88:715–719.

    Article  PubMed  CAS  Google Scholar 

  8. Sannohe Y, Hiratsuka R, Doki K. Lymph node metastases in cancer of the thoracic esophagus. Am J Surg 1981;141:216–218.

    Article  PubMed  CAS  Google Scholar 

  9. Akiyama H, Tsurumaru M, Kawamura T, Ono Y. Principles of surgical treatment for carcinoma of the esophagus: analysis of lymph node involvement. Ann Surg 1981;194:438–446.

    Article  PubMed  CAS  Google Scholar 

  10. Igaki H, Kato H, Tachimori Y, Sato H, Daiko H, Nakanishi Y. Prognostic evaluation for squamous cell carcinomas of the lower thoracic esophagus treated with three-field lymph node dissection. Eur J Cardiothorac Surg 2001;19:887–893.

    Article  PubMed  CAS  Google Scholar 

  11. Baba M, Aikou T, Yoshinaka H, et al. Long-term results of subtotal esophagectomy with three-field lymphadenectomy for carcinoma of the thoracic esophagus. Ann Surg 1994;219:31–36.

    Article  Google Scholar 

  12. Feith M, Stein HJ, Siewert JR. Pattern of lymphatic spread of Barrett’s cancer. World J Surg 2003;27: 1052–1057.

    Article  PubMed  Google Scholar 

  13. Romagnuolo J, Scott J, Hawes RH, et al. Helical CT versus EUS with fine needle aspiration for celiac nodal assessment in patients with esophageal cancer. Gastrointest Endosc 2002;55:648–654.

    Article  PubMed  Google Scholar 

  14. Reed CE, Mishra G, Sahai AV, Hoffman BJ, Hawes RH. Esophageal cancer staging: improved accuracy by endoscopic ultrasound of celiac lymph nodes. Ann Thorac Surg 1999;67:319–321; discussion 322.

    Article  PubMed  CAS  Google Scholar 

  15. Rasanen JV, Sihvo EI, Knuuti MJ, et al. Prospective analysis of accuracy of positron emission tomography, computed tomography, and endoscopic ultrasonography in staging of adenocarcinoma of the esophagus and the esophagogastric junction. Ann Surg Oncol 2003;10:954–960.

    Article  PubMed  Google Scholar 

  16. Catalano MF, Alcocer E, Chak A, et al. Evaluation of metastatic celiac axis lymph nodes in patients with esophageal carcinoma: accuracy of EUS. Gastrointest Endosc 1999;50:352–356.

    Article  PubMed  CAS  Google Scholar 

  17. Eloubeidi MA, Wallace MB, Reed CE, et al. The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer: a single-center experience. Gastrointest Endosc 2001;54:714–719.

    Article  PubMed  CAS  Google Scholar 

  18. Heeren PA, van Westreenen HL, Geersing GJ, van Dullemen HM, Plukker JT. Influence of tumor characteristics on the accuracy of endoscopic ultrasonography in staging cancer of the esophagus and esophagogastric junction. Endoscopy 2004;36:966–971.

    Article  PubMed  CAS  Google Scholar 

  19. Eloubeidi MA, Wallace MB, Hoffman BJ, et al. Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography. Ann Thorac Surg 2001;72:212–219; discussion 919–920.

    Article  PubMed  CAS  Google Scholar 

  20. Marsman WA, van Wissen M, Bergman JJ, et al. Outcome of patients with esophageal carcinoma and suspicious celiac lymph nodes as determined by endoscopic ultrasonography. Endoscopy 2004;36:961–965.

    Article  PubMed  CAS  Google Scholar 

  21. Parmar KS, Zwischenberger JB, Reeves AL, Waxman I. Clinical impact of endoscopic ultrasound-guided fine needle aspiration of celiac axis lymph nodes (M1a disease) in esophageal cancer. Ann Thorac Surg 2002;73:916–920; discussion 920–921.

    Article  PubMed  Google Scholar 

  22. Krasna MJ, Reed CE, Nedzwiecki D, et al. CALGB 9380: a prospective trial of the feasibility of thoracoscopy/ laparoscopy in staging esophageal cancer. Ann Thorac Surg 2001;71:1073–1079.

    Article  PubMed  CAS  Google Scholar 

  23. Luketich JD, Schauer P, Landreneau R, et al. Minimally invasive surgical staging is superior to endoscopic ultrasound in detecting lymph node metastases in esophageal cancer. J Thorac Cardiovasc Surg 1997;114:817–821; discussion 821–823.

    Article  PubMed  CAS  Google Scholar 

  24. Stein HJ, Kraemer SJ, Feussner H, Fink U, Siewert JR. Clinical value of diagnostic laparoscopy with laparoscopic ultrasound in patients with cancer of the esophagus or cardia. J Gastrointest Surg 1997;1:167–173.

    Article  PubMed  CAS  Google Scholar 

  25. Frizzell B, Sinha D, Williams T, Reed CE, Sherman CA, Turrisi A. Influence of celiac axis lymph nodes in the definitive treatment of esophageal cancer. Am J Clin Oncol 2003;26:215–220.

    Article  PubMed  Google Scholar 

  26. Christie NA, Rice TW, DeCamp MM, et al. M1a/M1b esophageal carcinoma: clinical relevance. J Thorac Cardiovasc Surg 1999;118:900–907.

    Article  PubMed  CAS  Google Scholar 

  27. Rice TW, Blackstone EH, Rybicki LA, et al. Refining esophageal cancer staging. J Thorac Cardiovasc Surg 2003;125:1103–1113.

    Article  PubMed  Google Scholar 

  28. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725–730.

    Article  PubMed  CAS  Google Scholar 

  29. Bedard EL, Inculet RI, Malthaner RA, Brecevic E, Vincent M, Dar R. The role of surgery and postoperative chemoradiation therapy in patients with lymph node positive esophageal carcinoma. Cancer 2001;91:2423–2430.

    Article  PubMed  CAS  Google Scholar 

  30. Rice TW, Adelstein DJ, Chidel MA, et al. Benefit of postoperative adjuvant chemoradiotherapy in locoregionally advanced esophageal carcinoma. J Thorac Cardiovasc Surg 2003;126:1590–1596.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag London Limited

About this chapter

Cite this chapter

Rice, T.W., Boffa, D.J. (2007). Celiac Lymph Nodes and Esophageal Cancer. In: Ferguson, M.K. (eds) Difficult Decisions in Thoracic Surgery. Springer, London. https://doi.org/10.1007/978-1-84628-474-8_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-474-8_33

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-384-0

  • Online ISBN: 978-1-84628-474-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics