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Motion and Bone Regeneration

  • Chapter
Engineering of Functional Skeletal Tissues

Part of the book series: Topics in Bone Biology ((TBB,volume 3))

Abstract

Bone is a living material composed of cells and an extracellular matrix (ECM) that has a multi-component structure [4]. The ECM of bone is composed of three phases: an inorganic mineral phase, an organic phase, and an aqueous phase. The inorganic phase of bone is calcium hydroxyapatite, Ca10(PO4)6(OH)2. The organic phase consists primarily of collagen fibers and associated noncollagenous ECM proteins. The molecular configuration of collagen provides binding sites for hydroxyapatite crystal nucleation and growth. The ECM is created and maintained by active bone cells: osteoblasts, osteoclasts, and osteocytes. Osteoblasts and osteocytes are involved in bone formation and maintenance, respectively, whereas osteoclasts promote resorption of bone [2], [99]. Bone is, in general, dynamic and constantly being remodeled by the action of these cells, and thus can regenerate itself.

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Authors and Affiliations

  1. Department of Orthodontics, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC, USA

    Ching-Chang Ko DDS, MS, PhD

  2. Department of Periodontics, University of Washington School of Dentistry, Seattle, WA, USA

    Martha J. Somerman DDS PhD

  3. Biomechanical Laboratory Department of Orthopedics, Mayo Clinic Rochester, Rochester, MN, USA

    Kai-Nan An PhD

Authors
  1. Ching-Chang Ko DDS, MS, PhD
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  2. Martha J. Somerman DDS PhD
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  3. Kai-Nan An PhD
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Editor information

Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, CT, USA

    Felix Bronner PhD (Professor Emeritus) (Professor Emeritus)

  2. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Mary C. Farach-Carson PhD (Professor of Biological Sciences) (Professor of Biological Sciences)

  3. Department of Bioengineering, Rice University, Houston, TX, USA

    Antonios G. Mikos PhD (Professor of Bioengineering) (Professor of Bioengineering)

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© 2007 Springer-Verlag London Limited

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Ko, CC., Somerman, M.J., An, KN. (2007). Motion and Bone Regeneration. In: Bronner, F., Farach-Carson, M.C., Mikos, A.G. (eds) Engineering of Functional Skeletal Tissues. Topics in Bone Biology, vol 3. Springer, London. https://doi.org/10.1007/978-1-84628-366-6_8

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  • DOI: https://doi.org/10.1007/978-1-84628-366-6_8

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-962-3

  • Online ISBN: 978-1-84628-366-6

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