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Engineering of Functional Skeletal Tissues pp 81–94Cite as

Engineering Polymeric Scaffolds for Bone Grafts

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Part of the book series: Topics in Bone Biology ((TBB,volume 3))

Abstract

Orthopedic injuries resulting from trauma or improper development often require surgical intervention to restore natural tissue function. Currently, over one million operations are performed annually for the surgical reconstruction of bone [50]. The well-known limitations associated with autografts, allografts, and bone cements have led to the investigation of synthetic polymers as support matrices for bone tissue engineering. Polymers are long-chain molecules that are formed by linking repetitive monomer units. They have been extensively studied for tissue-engineering applications. Constructs designed from these polymers can act as a support matrix to deliver cell populations or induce surrounding tissue ingrowth. The properties of scaffolds directly determine their success in tissue engineering and must be designed specifically for each application.

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Authors and Affiliations

  1. Bioengineering Graduate Program, University of Maryland, College Park, MD, USA

    Martha W. Betz BS

  2. Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA

    Diana M. Yoon BS

  3. Department of Chemical and Biomolecular Engineering and Bioengineering Graduate Program, University of Maryland, College Park, MD, USA

    John P. Fisher PhD

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  1. Martha W. Betz BS
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  2. Diana M. Yoon BS
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Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, CT, USA

    Felix Bronner PhD (Professor Emeritus) (Professor Emeritus)

  2. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Mary C. Farach-Carson PhD (Professor of Biological Sciences) (Professor of Biological Sciences)

  3. Department of Bioengineering, Rice University, Houston, TX, USA

    Antonios G. Mikos PhD (Professor of Bioengineering) (Professor of Bioengineering)

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Betz, M.W., Yoon, D.M., Fisher, J.P. (2007). Engineering Polymeric Scaffolds for Bone Grafts. In: Bronner, F., Farach-Carson, M.C., Mikos, A.G. (eds) Engineering of Functional Skeletal Tissues. Topics in Bone Biology, vol 3. Springer, London. https://doi.org/10.1007/978-1-84628-366-6_6

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