Biodegradable Orthopedic Implants

  • Hansoo Park
  • Johnna S. Temenoff
  • Antonios G. Mikos
Part of the Topics in Bone Biology book series (TBB, volume 3)


Over the past 30 years, there have been significant advances in the development of biodegradable materials [79]. In particular, these materials have received attention for use as implants to aid regeneration of orthopedic defects [49, 91]. Every year more than 3.1 million orthopedic surgeries are performed in the United States alone [1]. However, although current treatments using nondegradable fixation materials have proven efficacious, tissue-engineering approaches with biodegradable implants are being considered as promising future alternatives [8, 49]. One possible advantage of these systems is that biodegradable implants can be engineered to provide temporary support for bone fractures, and because they can degrade at a rate matching new tissue formation, their use can eliminate the need for a second surgery [49].


Tissue Engineering Anterior Cruciate Ligament Reconstruction Interference Screw Biomed Mater Cartilage Tissue Engineering 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    American Academy of Orthopaedic Surgeons website, Scholar
  2. 2.
    Ahsan T, Sah RL (1999) Biomechanics of integrative cartilage repair. Osteoarthritis Cartilage 7:29–40.PubMedGoogle Scholar
  3. 3.
    Ali SA, Zhong SP, Doherty PJ, Williams, DF (1993) Mechanisms of polymer degradation in implantable devices. I. Poly(caprolactone). Biomaterials 14:648–656.PubMedGoogle Scholar
  4. 4.
    Ambrose CG, Clyburn TA, Louden K, Joseph J, Wright J, Gulati P, et al. (2004) Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clin Orthop 421:293–299.PubMedGoogle Scholar
  5. 5.
    Amiel D, Frank C, Harwood F, Fronek J, Akeson W (1984) Tendons and ligaments: a morphological and biochemical comparison. J Orthop Res 1:257–265.PubMedGoogle Scholar
  6. 6.
    Andriano KP, Tabata Y, Ikada Y, Heller J (1999) In vitro and in vivo comparison of bulk and surface hydrolysis in absorbable polymer scaffolds for tissue engineering. J Biomed Mater Res 48:602–612.PubMedGoogle Scholar
  7. 7.
    Athanasiou K, Zhu C, Lanctot D, Agrawal C, Wang X (2000) Fundamentals of biomechanics in tissue engineering of bone. Tissue Eng 6:361–381.PubMedGoogle Scholar
  8. 8.
    Athanasiou KA, Agrawal CM, Barber FA, Burkhart SS (1998) Orthopaedic applications for PLA-PGA biodegradable polymers. Arthroscopy 14:726–737.PubMedGoogle Scholar
  9. 9.
    Awad HA, Erickson GR, Guilak F (2002) Biomaterials for cartilage tissue engineering. In: Lewandrowski K, Wise D, Trantolo D, Gresser J, Yaszemski M, Altobelli D, eds. Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications. Marcel Dekker, New York.Google Scholar
  10. 10.
    Barbensee JE, McIntire LV, Mikos AG (2000) Growth factor delivery for tissue engineering. Pharm Res 17:497–504.Google Scholar
  11. 11.
    Bostman O, Pihlajamaki H (2000) Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review. Biomaterials 21:2615–2621.PubMedGoogle Scholar
  12. 12.
    Bryant SJ, Anseth KS (2002) Hydrogel properties influence ECM production by chondrocytes photo-encapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res 59:63–72.PubMedGoogle Scholar
  13. 13.
    Butler DL, Goldstein SA, Guilak F (2000) Functional tissue engineering: the role of biomechanics. J Biomech Eng 122:570–575.PubMedGoogle Scholar
  14. 14.
    Caborn DN, Urban WPJ, Johnson DL, Nyland J, Pienkowski D (1997) Biomechanical comparison between BioScrew and titanium alloy interference screws for bone-patellar tendon-bone graft fixation in anterior cruciate ligament reconstruction. Arthroscopy 13: 229–232.PubMedGoogle Scholar
  15. 15.
    Chen VJ, Ma PX (2004) Nano-fibrous poly(-lactic acid) scaffolds with interconnected spherical macropores. Biomaterials 25:2065–2073.PubMedGoogle Scholar
  16. 16.
    Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, et al (2000) Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 21:2155–2161.PubMedGoogle Scholar
  17. 17.
    Claes LE, Ignatius AA, Rehm KE, Scholz C (1996) New bioresorbable pin for the reduction of small bony fragments: design, mechanical properties and in vitro degradation. Biomaterials 17:1621–1626.PubMedGoogle Scholar
  18. 18.
    Daamen WF, Nillesen STM, Hafmans T, Veerkamp JH, van Luyn MJA, van Kuppevelt TH (2005) Tissue response of defined collagen-elastin scaffolds in young and adult rats with special attention to calcification. Biomaterials 26:81–92.PubMedGoogle Scholar
  19. 19.
    Daniels AU, Chang MK, Andriano KP (1990) Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone. J Appl Biomater 1:57–78.PubMedGoogle Scholar
  20. 20.
    Disegi JA, Wyss H (1989) Implant materials for fracture fixation: a clinical perspective. Orthopedics 12:75–79.PubMedGoogle Scholar
  21. 21.
    Donahue HJ, Chen Q, Jacobs CR, Saunders MM, Yellowley CE (2001) Bone cells and mechanotransduction. In: Rosier R, Evans C, eds. Molecular Biology in Orthopaedics. American Academy of Orthopaedic Surgeons, Scottsdate, pp 179–190.Google Scholar
  22. 22.
    Drury JL, Dennis RG, Mooney DJ (2004) The tensile properties of alginate hydrogels. Biomaterials 25: 3187–3199.PubMedGoogle Scholar
  23. 23.
    Elisseeff J, McIntosh W, Anseth KS, Riley S, Ragan P, Langer R (2000) Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res 51:164–171.PubMedGoogle Scholar
  24. 24.
    Elisseeff J, McIntosh W, Fu K, Blunk BT, Langer R (2001) Controlled-release of IGF-I and TGF-beta1 in a photopolymerizing hydrogel for cartilage tissue engineering. J Orthop Res 19:1098–1104.PubMedGoogle Scholar
  25. 25.
    Fisher JP, Holland TA, Dean D, Engel PS, Mikos AG (2001) Synthesis and properties of photocross-linked poly(propylene fumarate) scaffolds. J Biomater Sci Polym Ed 12:673–687.PubMedGoogle Scholar
  26. 26.
    Fisher JP, Jo S, Mikos AG, Reddi AH (2004) Ther moreversible hydrogel scaffolds for articular cartilage engineering. J Biomed Mater Res 71A:268–274.Google Scholar
  27. 27.
    Fisher JP, Vehof JW, Dean D, van der Waerden JP, Holland TA, Mikos AG, et al. (2002) Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. J Biomed Mater Res 59:547–556.PubMedGoogle Scholar
  28. 28.
    Fleming JE, Muschler GF, Boehm C, Lieberman IH, McLain RF (2004) Intraoperative harvest and concentration of human bone marrow osteoprogenitors for enhancement of spinal fusion. In: Goldberg V, Caplan A, eds. Orthopedic Tissue Engineering: Basic Science and Practice. Marcel Decker, New York, pp 51–65.Google Scholar
  29. 29.
    Goodstone NJ, Cartwright A, Ashton B (2004) Effects of high molecular weight hyaluronan on chondrocytes cultured within a resorbable gelatin sponge. Tissue Eng 10:621–631.PubMedGoogle Scholar
  30. 30.
    Gordon TD, Schloesser L, Humphries DE, Spector M (2004) Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro. Tissue Eng 10:1287–1295.PubMedGoogle Scholar
  31. 31.
    Goulet F, Germain L, Rancourt D, Caron C, Normand A, Auger FA (1997) Tendons and ligaments. In: Lanza R, Langer R, eds. Principles of Tissue Engineering. Academic Press, San Diego, pp 633–644.Google Scholar
  32. 32.
    Gunatillake PA, Adhikari R (2003) Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 5:1–16.PubMedGoogle Scholar
  33. 33.
    Halstenberg S, Panitch A, Rizzi S, Hall H, Hubbell JA (2002) Biologically engineered protein-graftpoly( ethylene glycol) hydrogels: a cell adhesive and plasmin-degradable biosynthetic material for tissue repair. Biomacromolecules 3:710–723.PubMedGoogle Scholar
  34. 34.
    Hanson SR, Harker LA (1994) Blood coagulation and blood-material interactions. In: Ratner B, Hoffman A, Schoen F, Lemons J, eds. Biomaterials Science: An Introduction to Materials in Medicine. Hanser, New York.Google Scholar
  35. 35.
    Heath CA (2000) Cells for tissue engineering. Trends Biotechnol 18:17–19.PubMedGoogle Scholar
  36. 36.
    Heinegard D, King K, Morgelin M, Rosenberg K, Wiberg C (2001) Matrix molecules with roles in cartilage assembly. In: Rosier R, Evans C, eds. Molecular Biology in Orthopaedics. American Academy of Orthopaedic Surgeons, Scottsdale, pp 315–323.Google Scholar
  37. 37.
    Higashi S, Yamamuro T, Nakamura T, Ikada Y, Hyon SH, Jamshidi K (1986) Polymer-hydroxyapatite composites for biodegradable bone fillers. Biomaterials 7:183–187.PubMedGoogle Scholar
  38. 38.
    Holland TA, Bodde EW, Baggett LS, Tabata Y, Mikos AG, Jansen JA (2005) Osteochondral repair in the rabbit model utilizing bilayered, degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds. J Biomed Mater Res A 75:156–167.PubMedGoogle Scholar
  39. 39.
    Holland TA, Mikos AG (2003) Advances in drug delivery for articular cartilage. J Control Release 86:1–14.PubMedGoogle Scholar
  40. 40.
    Holland TA, Tabata Y, Mikos AG (2003) In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels. J Control Release 91:299–313.PubMedGoogle Scholar
  41. 41.
    Holland TA, Tessmar JKV, Tabata Y, Mikos AG (2003) Transforming growth factor-1 release from oligo (poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment. J Control Release 94:101–114.Google Scholar
  42. 42.
    Hollinger JO (1983) Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA). J Biomed Mater Res 17:71–82.PubMedGoogle Scholar
  43. 43.
    Horch RA, Shahid N, Mistry AS, Timmer MD, Mikos AG, Barron AR (2004) Nanoreinforcement of poly (propylene fumarate)-based networks with surface modified alumoxane nanoparticles for bone tissue engineering. Biomacromolecules 5:1990–1998.PubMedGoogle Scholar
  44. 44.
    Huang W, Carlsen B, Wulur I, Rudkin G, Ishida K, Wu B, et al. (2004) BMP-2 exerts differential effects on differentiation of rabbit bone marrow stromal cells grown in two-dimensional and three-dimensional systems and is required for in vitro bone formation in a PLGA scaffold. Exp Cell Res 299: 325–334.PubMedGoogle Scholar
  45. 45.
    Hunziker EB (1992) The different types of chondrocytes and their function in vivo. In: Adolphe M, ed. Biological Regulation of the Chondrocytes. CRC Press, Boca Raton, pp 1–31.Google Scholar
  46. 46.
    Ibusuki S, Fujii Y, Iwamoto Y, Matsuda T (2003) Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin: fabrication and in vitro performance. Tissue Eng 9:371–84.PubMedGoogle Scholar
  47. 47.
    Iooss P, Le Ray AM, Grimandi G, Daculsi G, Merle C (2001) A new injectable bone substitute combining poly(epsilon-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials 22:2785–2794.PubMedGoogle Scholar
  48. 48.
    Ishaug-Riley SL, Crane-Kruger GM, Yaszemski MJ, Mikos AG (1998) Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 19:1405–1412.PubMedGoogle Scholar
  49. 49.
    Jackson DW, Simon TM (1999) Tissue engineering principles in orthopaedic surgery. Clin Orthop 367S: 31–45.Google Scholar
  50. 50.
    Jeong B, Kim SW, Bae YH (2002) Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev 54:37–51.PubMedGoogle Scholar
  51. 51.
    Jo S, Shin H, Shung AK, Fisher JP, Mikos AG (2001) Synthesis and characterization of oligo(poly(ethylene glycol) fumarate) macromer. Macromolecules 34: 2839–2845.Google Scholar
  52. 52.
    Kang SI, Bae YH (2004) pH-dependent elution profiles of selected proteins in HPLC having a stationary phase modified with pH-sensitive sulfonamide polymers. J Biomater Sci Polym Ed 15:879–894.PubMedGoogle Scholar
  53. 53.
    Karp JM, Sarraf F, Shoichet MS, Davies JE (2004) Fibrin-filled scaffolds for bone-tissue engineering: an in vivo study. J Biomed Mater Res 71A:162–171.Google Scholar
  54. 54.
    Kasper FK, Seidlits SK, Tang A, Crowther RS, Carney DH, Barry MA, et al (2005) In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels. J Control Release 104:521–539.PubMedGoogle Scholar
  55. 55.
    Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, et al. (2002) Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci USA 99:9996–10001.PubMedGoogle Scholar
  56. 56.
    Kohn J, Langer R (1994) Bioresorbable and bioerodible materials. In: Ratner B, Hoffman A, Schoen F, Lemons J, eds. Biomaterials Science: An Introduction to Materials in Medicine. Hanser, New York, pp 65–73.Google Scholar
  57. 57.
    Kojima K, Ignotz RA, Kushibiki T, Tinsley KW, Tabata Y, Vacanti CA (2004) Tissue-engineered trachea from sheep marrow stromal cells with transforming growth factor [beta]2 released from biodegradable microspheres in a nude rat recipient. J Thorac Cardiovasc Surg 128:147–153.PubMedGoogle Scholar
  58. 58.
    Leddy HA, Awad HA, Guilak F (2004) Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. J Biomed Mater Res 70B:397–406.Google Scholar
  59. 59.
    Lee CH, Singla A, Lee Y (2001) Biomedical applications of collagen. Int J Pharm 221:1–22.PubMedGoogle Scholar
  60. 60.
    Lee CR, Grodzinsky AJ, Spector M (2001) The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocytemediated contraction, proliferation and biosynthesis. Biomaterials 22:3145–3154.PubMedGoogle Scholar
  61. 61.
    Lee JE, Kim KE, Kwon IC, Ahn HJ, Lee SH, Cho H, et al. (2004) Effects of the controlled-released TGF-[beta]1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glycosaminoglycan scaffold. Biomaterials 25:4163–4173.PubMedGoogle Scholar
  62. 62.
    Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101:1869–1880.PubMedGoogle Scholar
  63. 63.
    Li WJ, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, et al. (2005) A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 26: 599–609.PubMedGoogle Scholar
  64. 64.
    Lima EG, Mauck RL, Han SH, Park S, Ng KW, Ateshian GA, et al. (2004) Functional tissue engineering of chondral and osteochondral constructs. Biorheology 41:577–590.PubMedGoogle Scholar
  65. 65.
    Lu L, Peter SJ, Lyman MD, Lai HL, Leite SM, Tamada JA, et al. (2000) In vitro degradation of porous poly(-lactic acid) foams. Biomaterials 21:1595–1605.PubMedGoogle Scholar
  66. 66.
    Luginbuehl V, Meinel L, Merkle HP, Gander B (2004) Localized delivery of growth factors for bone repair. Eur J Pharm Biopharm 58:197–208.PubMedGoogle Scholar
  67. 67.
    Lutolf MP, Hubbell JA (2003) Synthesis and physicochemical characterization of end-linked poly (ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules 4:713–722.PubMedGoogle Scholar
  68. 68.
    Ma Z, Gao C, Gong Y, Shen J (2005) Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast growth factor. Biomaterials 26:1253–1259.PubMedGoogle Scholar
  69. 69.
    Mauck RL, Wang CC, Oswald ES, Ateshian GA, Hung CT (2003) The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthritis Cartilage 11:879–890.PubMedGoogle Scholar
  70. 70.
    Middleton JC, Tipton AJ (2000) Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21:2335–2346.PubMedGoogle Scholar
  71. 71.
    Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R (1993) Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res 27:183–189.PubMedGoogle Scholar
  72. 72.
    Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, et al. (1994) Preparation and characterization of poly(L-lactic acid) foams. Polymer 35:1068–1077.Google Scholar
  73. 73.
    Moreira PL, An YH, Santos AR Jr, Genari SC (2004) In vitro analysis of anionic collagen scaffolds for bone repair. J Biomed Mater Res 71B:229–237.Google Scholar
  74. 74.
    O’Driscoll SW (1999) Articular cartilage regeneration using periosteum. Clin Orthop 367S:S186–203.Google Scholar
  75. 75.
    Ouyang HW, Goh JC, Thambyah A, Teoh SH, Lee EH (2003) Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. Tissue Eng 9:431–439.PubMedGoogle Scholar
  76. 76.
    Pachence JM, Kohn J (1997) Biodegradable polymers for tissue engineering. In: Lanza R, Langer R, eds. Principles of Tissue Engineering. Academic Press, San Diego, pp 273–293.Google Scholar
  77. 77.
    Park H, Temenoff JS, Holland TA, Tabata Y, Mikos AG (2005) Delivery of TGF-β and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials 2005: 26:7095–7103.PubMedGoogle Scholar
  78. 78.
    Park SN, Park JC, Kim HO, Song MJ, Suh H (2002) Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopr opyl)carbodiimide cross-linking. Biomaterials 23: 1205–1212.PubMedGoogle Scholar
  79. 79.
    Peppas NA, Langer R (1994) New challenges in biomaterials. Science 263:1715–1720.PubMedGoogle Scholar
  80. 80.
    Podual K, Doyle FJ III, Peppas NA (2000) Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase. Polymer 41:3975–3983.Google Scholar
  81. 81.
    Pulapura S, Kohn J (1992) Tyrosine-derived polycarbonates: backbone-modified “pseudo”-poly (amino acids) designed for biomedical applications. Biopolymers 32:411–417.PubMedGoogle Scholar
  82. 82.
    Quick DJ, Anseth KS (2004) DNA delivery from photocrosslinked PEG hydrogels: encapsulation efficiency, release profiles, and DNA quality. J Control Release 96:341–351.PubMedGoogle Scholar
  83. 83.
    Rice MA, Anseth KS (2004) Encapsulating chondrocytes in copolymer gels: bimodal degradation kinetics influence cell phenotype and extracellular matrix development. J Biomed Mater Res 70A:560–568.Google Scholar
  84. 84.
    Rupp S, Krauss PW, Fritsch EW (1997) Fixation strength of a biodegradable interference screw and a press-fit technique in anterior cruciate ligament reconstruction with a BPTB graft. Arthroscopy 13: 61–65.PubMedGoogle Scholar
  85. 85.
    Shin H, Jo S, Mikos AG (2003) Biomimetic materials for tissue engineering. Biomaterials 24:4353–4364.PubMedGoogle Scholar
  86. 86.
    Shin H, Quinten-Ruhe P, Mikos AG, Jansen JA (2003) In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels. Biomaterials 24:3201–3211.PubMedGoogle Scholar
  87. 87.
    Shin H, Zygourakis K, Farach-Carson MC, Yaszemski MJ, Mikos AG (2004) Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides. J Biomed Mater Res 69A:535–543.Google Scholar
  88. 88.
    Suh JK, Matthew HW (2000) Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 21:2589–2598.PubMedGoogle Scholar
  89. 89.
    Tabata Y, Ikada Y (1988) Macrophage phagocytosis of biodegradable microspheres composed of L-lactic acid/glycolic acid homo-and copolymers. J Biomed Mater Res 22:837–858.PubMedGoogle Scholar
  90. 90.
    Tamada J, Langer R (1992) The development of polyanhydrides for drug delivery applications. J Biomater Sci Polym Ed 3:315–353.PubMedGoogle Scholar
  91. 91.
    Temenoff JS, Mikos AG (2000) Injectable biodegradable materials for orthopaedic tissue engineering. Biomaterials 21:2405–2412.PubMedGoogle Scholar
  92. 92.
    Temenoff JS, Mikos AG (2000) Review: tissue engineering for regeneration of articular cartilage. Biomaterials 21:431–440.PubMedGoogle Scholar
  93. 93.
    Temenoff JS, Park H, Jabbari E, Conway DE, Sheffield TL, Ambrose CG, et al. (2004) Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules 5:5–10.PubMedGoogle Scholar
  94. 94.
    Temenoff JS, Park H, Jabbari E, Sheffield TL, LeBaron RG, Ambrose CG, et al. (2004) In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. J Biomed Mater Res 70A:235–244.Google Scholar
  95. 95.
    Temenoff JS, Shin H, Conway DE, Engel PS, Mikos AG (2003) In vitro cytotoxicity of redox radical initiators for cross-linking of oligo(poly(ethylene glycol) fumarate) macromers. Biomacromolecules 4:1605–1613.PubMedGoogle Scholar
  96. 96.
    Temenoff JS, Steinbis ES, Mikos AG (2004) Biodegradable scaffolds. In: Goldberg V, Caplan A, eds. Orthopedic Tissue Engineering: Basic Science and Practice. Marcel Decker, New York, pp 77–103.Google Scholar
  97. 97.
    Thornton AJ, Alsberg E, Albertelli M, Mooney DJ (2004) Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation 77:1798–1803.PubMedGoogle Scholar
  98. 98.
    Timmer MD, Carter C, Ambrose CG, Mikos AG (2003) Fabrication of poly(propylene fumarate)-based orthopaedic implants by photo-crosslinking through transparent silicone molds. Biomaterials 24:4707–4714.PubMedGoogle Scholar
  99. 99.
    Tuli R, Nandi S, Li WJ, Tuli S, Huang X, Manner PA, et al. (2004) Human mesenchymal progenitor cellbased tissue engineering of a single-unit osteochondral construct. Tissue Eng 10:1169–1179.PubMedGoogle Scholar
  100. 100.
    Vacanti JP, Langer R, Upton J, Marler JJ (1998) Transplantation of cells in matrices for tissue regeneration. Adv Drug Deliv Rev 33:165–182.PubMedGoogle Scholar
  101. 101.
    Weiner S, Traub W (1992) Bone structure: from angstroms to microns. FASEB J 6:879–885.PubMedGoogle Scholar
  102. 102.
    Williams CG, Kim TK, Taboas A, Maliak AN, Manson P, Elisseeff JH (2003) In vitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng 9:679–688.PubMedGoogle Scholar
  103. 103.
    Williamson AK, Chen AC, Sah RL (2001) Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res 19:1113–1121.PubMedGoogle Scholar
  104. 104.
    Yamamoto M, Takahashi Y, Tabata Y (2003) Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 24:4375–4383.PubMedGoogle Scholar
  105. 105.
    Yamane S, Iwasaki N, Majima T, Funakoshi T, Masuko T, Harada K, et al. (2005) Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering. Biomaterials 26:611–619.PubMedGoogle Scholar
  106. 106.
    Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG (1996) In vitro degradation of a poly(propylene fumarate)-based composite material. Biomaterials 17:2127–2130.PubMedGoogle Scholar
  107. 107.
    Zhang SM, Cui FZ, Liao SS, Zhu Y, Han L (2003) Synthesis and biocompatibility of porous nanohydroxyapatite/collagen/alginate composite. J Mater Sci Mater Med 14:641–645.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Hansoo Park
    • 1
  • Johnna S. Temenoff
    • 1
  • Antonios G. Mikos
    • 1
  1. 1.Department of BioengineeringRice UniversityHoustonUSA

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