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Bone Allograft Safety and Performance

  • Calin S. Moucha
  • Regis L. Renard
  • Ankur Gandhi
  • Sheldon S. Lin
  • Rocky S. Tuan
Chapter
Part of the Topics in Bone Biology book series (TBB, volume 3)

Abstract

Bone allograft transplantation is a common practice; in the United States 650,000 procedures were performed in 1999, a 186% increase from 1990 [3]. This increase can be attributed to morbidities associated with bone autografts [6, 18, 30, 35, 59], the increased availability of bone allografts, and the expansion of these applications [9, 16, 21, 22, 29, 31, 42, 66]. A variety of musculoskeletal allografts are available for different reconstructive applications. Bone allograft is an alternative to autograft because it has osteoconductive properties, acts as a scaffold for bone growth, and induces bone formation by providing osteogenic factors, in addition to mesenchymal precursor cells, osteoblasts, and osteocytes. Although these properties are advantageous, the potential for the transmission of infectious diseases remains a great concern [1, 2, 4, 10, 12, 24, 26, 27, 32, 38, 49, 53].

Keywords

Bone Graft Tissue Bank Human Immunodeficiency Virus Bone Allograft Human Immunodeficiency Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Calin S. Moucha
    • 1
  • Regis L. Renard
    • 2
  • Ankur Gandhi
    • 2
  • Sheldon S. Lin
    • 3
  • Rocky S. Tuan
    • 4
  1. 1.Division of Adult Joint Replacement Department of Orthopedics New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA
  2. 2.Department of Orthopedics New Jersey Medicine SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA
  3. 3.Foot and Ankle Division Department of Orthopedics New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA
  4. 4.Cartilage Biology and Orthopedics Branch National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institutes of HealthBethesdaUSA

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