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Engineering of Functional Skeletal Tissues pp 46–54Cite as

Bone Allograft Safety and Performance

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Part of the book series: Topics in Bone Biology ((TBB,volume 3))

Abstract

Bone allograft transplantation is a common practice; in the United States 650,000 procedures were performed in 1999, a 186% increase from 1990 [3]. This increase can be attributed to morbidities associated with bone autografts [6, 18, 30, 35, 59], the increased availability of bone allografts, and the expansion of these applications [9, 16, 21, 22, 29, 31, 42, 66]. A variety of musculoskeletal allografts are available for different reconstructive applications. Bone allograft is an alternative to autograft because it has osteoconductive properties, acts as a scaffold for bone growth, and induces bone formation by providing osteogenic factors, in addition to mesenchymal precursor cells, osteoblasts, and osteocytes. Although these properties are advantageous, the potential for the transmission of infectious diseases remains a great concern [1, 2, 4, 10, 12, 24, 26, 27, 32, 38, 49, 53].

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Author information

Authors and Affiliations

  1. Division of Adult Joint Replacement Department of Orthopedics New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

    Calin S. Moucha MD

  2. Department of Orthopedics New Jersey Medicine School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

    Regis L. Renard MD & Ankur Gandhi PhD

  3. Foot and Ankle Division Department of Orthopedics New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

    Sheldon S. Lin MD

  4. Cartilage Biology and Orthopedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA

    Rocky S. Tuan PhD

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  1. Calin S. Moucha MD
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  2. Regis L. Renard MD
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  3. Ankur Gandhi PhD
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  4. Sheldon S. Lin MD
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  5. Rocky S. Tuan PhD
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Editor information

Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, CT, USA

    Felix Bronner PhD (Professor Emeritus) (Professor Emeritus)

  2. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Mary C. Farach-Carson PhD (Professor of Biological Sciences) (Professor of Biological Sciences)

  3. Department of Bioengineering, Rice University, Houston, TX, USA

    Antonios G. Mikos PhD (Professor of Bioengineering) (Professor of Bioengineering)

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Moucha, C.S., Renard, R.L., Gandhi, A., Lin, S.S., Tuan, R.S. (2007). Bone Allograft Safety and Performance. In: Bronner, F., Farach-Carson, M.C., Mikos, A.G. (eds) Engineering of Functional Skeletal Tissues. Topics in Bone Biology, vol 3. Springer, London. https://doi.org/10.1007/978-1-84628-366-6_3

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  • DOI: https://doi.org/10.1007/978-1-84628-366-6_3

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