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Osteogenic Growth Factors and Cytokines and Their Role in Bone Repair

  • Chapter
Engineering of Functional Skeletal Tissues

Part of the book series: Topics in Bone Biology ((TBB,volume 3))

Abstract

Ontogenetic development is initiated at the time of fertilization and terminates with the differentiation, growth, and maturation of specialized tissues and organs. These developmental processes are characterized by molecular specialization that accompanies cellular differentiation and tissue morphogenesis. Most developmental processes terminate after birth or when animals reach sexual maturity, but some morphogenetic processes are reinitiated in response to injury in specific tissues. One such regenerative process is the repair of skeletal fractures and bone tissue after surgery, a process that recapitulates specific aspects of the initial developmental processes in the course of healing [58, 209]. Several aspects of the postnatal tissue environment of fracture healing, however, are unique and differ from what occurs in embryological and postnatal development.

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Authors and Affiliations

  1. Orthopedic Research Laboratory Department of Orthopedic Surgery Boston University Medical Center, Boston University School of Medicine, Boston, MA, USA

    Louis C. Gerstenfeld PhD, Cory M. Edgar PhD, Sanjeev Kakar MD, MRCS, Kimberly A. Jacobsen MA & Thomas A. Einhorn MD

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  1. Louis C. Gerstenfeld PhD
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  2. Cory M. Edgar PhD
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  3. Sanjeev Kakar MD, MRCS
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  4. Kimberly A. Jacobsen MA
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  5. Thomas A. Einhorn MD
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Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, CT, USA

    Felix Bronner PhD (Professor Emeritus) (Professor Emeritus)

  2. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Mary C. Farach-Carson PhD (Professor of Biological Sciences) (Professor of Biological Sciences)

  3. Department of Bioengineering, Rice University, Houston, TX, USA

    Antonios G. Mikos PhD (Professor of Bioengineering) (Professor of Bioengineering)

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© 2007 Springer-Verlag London Limited

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Gerstenfeld, L.C., Edgar, C.M., Kakar, S., Jacobsen, K.A., Einhorn, T.A. (2007). Osteogenic Growth Factors and Cytokines and Their Role in Bone Repair. In: Bronner, F., Farach-Carson, M.C., Mikos, A.G. (eds) Engineering of Functional Skeletal Tissues. Topics in Bone Biology, vol 3. Springer, London. https://doi.org/10.1007/978-1-84628-366-6_2

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  • DOI: https://doi.org/10.1007/978-1-84628-366-6_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-962-3

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