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The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence

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Adipose Tissue and Adipokines in Health and Disease

Part of the book series: Nutrition and Health ((NH))

Abstract

White adipose tissue (WAT) is an immensely plastic organ that plays a vital role in regulating metabolic homeostasis and systemic inflammation. Advancing age mitigates the dynamic nature of WAT which promotes the manifestation of several lipodystrophic-associated comorbidities. Inflammation and the accumulation of senescence cells likely play a key role in this process by inhibiting adipogenesis. The reduction of WAT functional capacity with aging and the role that inflammation and cellular senescence may play in this process will be explored throughout this review.

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Acknowledgements

This work was supported by NIH grants AG13925 (JLK), AG31736 (A. Bartke), and AG41122 (JLK), the Robert and Arlene Kogod Center on Aging, and the Noaber, Glenn, and Ellison Foundations.

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Authors and Affiliations

  1. Mayo Clinic, Robert & Arlene Kogod Center on Aging, 200 First Street SW, Rochester, MN, 55905, USA

    Michael B. Stout Ph.D., Tamara Tchkonia Ph.D. & James L. Kirkland M.D., Ph.D.

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Correspondence to James L. Kirkland M.D., Ph.D. .

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  1. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Giamila Fantuzzi

  2. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Carol Braunschweig

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Stout, M.B., Tchkonia, T., Kirkland, J.L. (2014). The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence. In: Fantuzzi, G., Braunschweig, C. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-770-9_5

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  • DOI: https://doi.org/10.1007/978-1-62703-770-9_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-769-3

  • Online ISBN: 978-1-62703-770-9

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