Abstract
Women with chronic kidney disease (CKD) who become pregnant during the early stages of the disease while undergoing chronic dialysis or after renal transplantation are all considered to be at high risk for complications. Hypertension is the most prevalent life-threatening maternal complication during pregnancy in all stages of CKD. There is also a greater risk for more rapid decline in kidney function for women who become pregnant with a serum creatinine greater than or equal to 1.4 mg/dL, and especially for those who have levels >2.0 mg/dL [1]. Women who become pregnant after a kidney transplant do not have an increased risk for loss of kidney function if the function includes a creatinine <1.5 mg/dL and <500 mg/24 h protein excretion [1, 2]. Immunosuppressive medications (especially cyclosporine), however, have been known to contribute to infants born small for gestational age. These medications have not been shown to increase abnormalities in the fetus, except for mycophenolate mofetil, which is now believed to be teratogenic [3]. The incidence of premature birth also remains high for women during all stages of CKD [1].
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Stover, J. (2014). Pregnancy. In: Byham-Gray, L., Burrowes, J., Chertow, G. (eds) Nutrition in Kidney Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-685-6_17
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DOI: https://doi.org/10.1007/978-1-62703-685-6_17
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