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Ion and Fluid Dynamics in Hypertension

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Pediatric Hypertension

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

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Abstract

The role of ion transport in hypertension has been the focus of much investigation, and manipulation of ion transport is utilized therapeutically. However, the mechanisms behind sodium flux that lead to hypertension are not well understood. Target proteins and diuretic agents, monogenic forms of hypertension, and genetic disorders of renal salt wasting have all provided insight into these pathways. This chapter reviews some of the channels involved in blood pressure regulation and their relevance to human hypertension.

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Authors and Affiliations

  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at Massachusetts General Hospital, 55 Fruit Street, Yawkey 6C, Boston, MA, 02114, USA

    Avram Z. Traum M.D.

  2. Department of Pediatrics, Harvard Medical School, Boston, USA

    Avram Z. Traum M.D.

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  1. Avram Z. Traum M.D.
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Correspondence to Avram Z. Traum M.D. .

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Editors and Affiliations

  1. University of Washington, Division of Pediatrics, Seattle Children's Hospital, Sand Point Way NE. 4800, Seattle, 98105, Washington, USA

    Joseph T. Flynn

  2. Harvard Medical School, Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Julie R. Ingelfinger

  3. Global Clinical Research, Bristol-Myers Squibb, Route 206 & Provinceline Road, Princeton, 08543, New Jersey, USA

    Ronald J. Portman

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Traum, A.Z. (2013). Ion and Fluid Dynamics in Hypertension. In: Flynn, J., Ingelfinger, J., Portman, R. (eds) Pediatric Hypertension. Clinical Hypertension and Vascular Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-490-6_4

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