Abstract
Transient receptor potential (TRP) ion channels act as molecular sensors and transducers of diverse stimuli into cellular and physiological responses. Accumulating evidence has implicated the regulatory roles of TRP ion channels in various human diseases including malignancies. The requirement of the TRP melastatin-subfamily members, TRPM7 and TRPM8, in pancreatic development and cancer has been brought to light in recent discovery. Investigation of the mechanisms that mediate the functional roles of these TRP channels is expected to generate new insights into the pathogenesis of pancreatic neoplasia, and facilitate development of clinical biomarkers and therapeutic targets toward the goal of personalized therapy in pancreatic cancer.
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Acknowledgements
N.S.Y. is supported by the Physician Scientist Stimulus Package from The Pennsylvania State University College of Medicine. The research work in the laboratory of N.S.Y. has been funded by Penn State Hershey Cancer Institute, The University of Iowa Carver College of Medicine, Holden Comprehensive Cancer Center at The University of Iowa, National Institutes of Health (NIDDK and NCI), American Cancer Society, and Fraternal Orders of Eagles.
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Yee, N.S., Yee, R.K. (2013). Ion Channels as Novel Pancreatic Cancer Biomarkers and Targets. In: Lee, N., Cheng, C., Luk, J. (eds) New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-456-2_5
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DOI: https://doi.org/10.1007/978-1-62703-456-2_5
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