Abstract
PPARs were originally described as orphan nuclear receptors, but numerous potential endogenous ligand(s) were soon described; however, the real identity of true endogenous PPAR ligand is still very much debated (Varga et al. 2011). All three PPARs are activated by a variety of polyunsaturated long-chain fatty acids and arachidonic acid derivatives (Dreyer et al. 1993; Grimaldi 2007). Because of this, it has been hypothesized that PPARs act as lipid sensors rather than being specific receptors for one particular lipid molecule. This idea suggests an important role for these receptors in adapting the metabolic rates of various tissues to the concentration of dietary lipids (Grimaldi 2007). In addition to these naturally occurring molecules, numerous synthetic ligands of varying selectivity bind to and activate various PPAR subtypes. The lack of strict specificity of ligand binding to PPARs might be attributed, at least in part, to the unusually large ligand-binding pocket in these receptors compared to other more specific nuclear hormone receptors.
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Barnett D, Craig JG, Robinson DS, Rogers MP (1977) Effect of clofibrate on glucose tolerance in maturity onset diabetes. Br J Clin Pharmacol 4:455–458
Bentley P, Calder I, Elcombe C, Grasso P, Stringer D, Wiegand HJ (1993) Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem Toxicol 31:857–907
Blumcke S, Schwartzkopff W, Lobeck H, Edmondson NA, Prentice DE, Blane GF (1983) Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients. Atherosclerosis 46:105–116
Bouaboula M, Hilairet S, Marchand J, Fajas L, Le Fur G, Casellas P (2005) Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. Eur J Pharmacol 517:174–178
Bugge A, Mandrup S (2010) Molecular mechanisms and genome-wide aspects of PPAR subtype specific transactivation. PPAR Res 2010:169506
Cantello BC, Cawthorne MA, Cottam GP, Duff PT, Haigh D, Hindley RM, Lister CA, Smith SA, Thurlby PL (1994) [[omega-(Heterocyclyamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J Med Chem 37:3977–3985
Cattley RC, DeLuca J, Elconbe C, Fenner-Crisp P, Lake BG, Marsman DS, Pastor TA, Popp JA, Robinson DE, Schwetz B, Tugwood J, Wahli W (1998) Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regul Toxicol Pharmacol 27:47–60
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF (2009) Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 138:476–488
Chang AY, Wyse BM, Gilchrist BJ, Peterson T, Diani AR (1983) Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters and normal and streptozotosin-diabetic rats. Diabetes 32:830–838
Cheatham WW (2010) Peroxisome proliferator-activated receptor translational research and clinical experience. Am J Clin Nutr 91:262S–266S
Coleman JD, Prabhu KS, Thompson JT, Reddy PS, Peters JM, Peterson BR, Reddy CC, Vanden Heuvel JP (2007) The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med 42:1155–1164
Cottet J, Redel J, Krumm-Heller C, Tricaud ME (1953) Hypocholesterolemic property of sodium phenyl ethyl acetate (22 TH) in the rat. Bull Acad Natl Med 137:441–442
Delerive P, Furman C, Teissier E, Fruchart J, Duriez P, Staels B (2000) Oxidized phospholipids activate PPARalpha in a phospholipase A2-dependent manner. FEBS Lett 47:34–38
Dreyer C, Keller H, Mahfoudi A, Laudet V, Krey G, Wahli W (1993) Positive regulation of peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator–activated receptors (PPAR). Biol Cell 77:67–76
Esposito E, Cuzzocrea S (2011) Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury. Expert Opin Ther Targets 15:943–959
Fievet C, Fruchart JC, Stales B (2006) PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and metabolic syndrome. Curr Opin Pharmacol 6:606–614
Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D (2005) Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology 48:1147–1153
Fujita T, Sugiyama Y, Taketomi S, Sohda T, Kawamatsu Y, Iwatsuka H, Suzuoki Z (1983) Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexyl methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent. Diabetes 32:804–810
Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I, Horikoshi H (1988) Characterization of a new oral antidiabetic agent CS-045: studies in kk and ob/ob mice and zucker fatty rats. Diabetes 37:1549–1558
Fyffe SA, Alphey MS, Buetow L, Smith TK, Ferguson MA, Sørensen MD, Björkling F, Hunter WN (2006) Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids. J Mol Biol 356:1005–10013
Gearing KL, Gottlicher M, Teboul M, Widmark E, Gustafson JA (1993) Interaction of peroxisome-proliferator-activated receptor and retinoid x-receptor. Proc Natl Acad Sci USA 90:1440–1444
Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T (2007) COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med 204:2053–2061
Gonzalez IC, Lamar J, Iradier F, Xu Y, Winneroski LL, York J, Yumibe N, Zink R, Montrose-Rafizadeh C, Etgen GJ, Broderick CL, Oldham BA, Mantlo N (2007) Design and synthesis of a novel class of dual PPARgamma/delta agonists. Bioorg Med Chem Lett 17:1052–1055
Goto T, Nagai H, Egawa K, Kim YI, Kato S, Taimatsu A, Sakamoto T, Ebisu S, Hohsaka T, Miyagawa H, Murakami S, Takahashi N, Kawada T (2011) Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. Biochem J 438:111–119
Grimaldi PA (2007) Peroxisome proliferator activated receptors as sensors of fatty acids and derivatives. Cell Mol Life Sci 64:2459–2464
Gulick T, Cresci S, Caira T, Moore DD, Kelly DP (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 91:11012–11016
Gupta RA, Tan J, Krause WF, Geraci MW, Willson TM, Dey SK, DuBois RN (2000) Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci USA 97:13275–13280
Hess R, Staubli W, Riess W (1965) Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208:856–858
Ijpenberg A, Jeanin E, Wahli W, Desvergne B (1997) Polrity and specific sequence requirements of peroxisome proliferator-activated receptor heterodimer binding to DNA. A functional analysis of the malic enzyme PPAR response element. J Biol Chem 272:20108–20117
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM (1992) Convergence of 9-Cis retinoic acid and peroxisome proliferator signaling pathways through heterodimer formation of their receptors. Nature 358:771–774
Lalloyer F, Staels B (2010) Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol 30:894–899
Leibowitz MD, Fiévet C, Hennuyer N, Peinado-Onsurbe J, Duez H, Bergera J, Cullinan CA, Sparrow CP, Baffic J, Berger GD, Santini C, Marquis RW, Tolman RL, Smith RG, Moller DE, Auwerx J (2000) Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett 473:333–336
Lim H, Gupta R, Ma W-G, Paria B, Moller D, Morrow J, DuBois R, Trzaskos J, Dey S (1999) Cyclooxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARγ. Gene Dev 13:1561–1574
Mathivat A, Cottet J (1953) Clinical trials on the hypocholesterolimia producing effect of 2-phenyl butyric acid. Bull Mem Soc Med Hop Paris 69:1030–1048
Matzkies F, Schulzky D, Berg G (1978) Porcetofen, a new lipid-and urine-acid-reducing substance. Frtschr Med 96:1939–1941
Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM (2002) Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem 277:41925–41930
Narala VR, Adapala RK, Suresh MV, Brock TG, Peters-Golden M, Reddy RC (2010) Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 285:22067–22074
Nielsen R, Grontved L, Stunnenberg HG, Mandrup S (2006) Peroxisome proliferator-activated receptor subtype-and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery. Mol Cell Biol 26:5698–5714
Oakes ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW (1994) A new antidiabetic agent, BRL-49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 43:1203–1210
Oberkofler H, Esterbauer H, Linnemayr V, Strosberg AD, Krempler F, Patsch W (2002) Peroxisome proliferator activated receptor (PPAR) γ coactivator-1 recruitment regulates PPAR subtype specificity. J Biol Chem 277:16750–16757
O’Sullivan SE, Kendall DA (2010) Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. Immunobiology 215:611–616
Reddy JK, Azamoff DL, Hignite CE (1980) Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature 283:397–398
Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B (2007) Safety issues and prospects for future generations of PPAR modulators. Biochim Biophys Acta 1771:1065–1081
Schopfer FJ, Lin Y, Baker PR, Cui T, Garcia-Barrio M, Zhang J, Chen K, Chen YE, Freeman BA (2005) Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand. Proc Natl Acad Sci USA 102:2340–2345
Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA (2010) Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. J Biol Chem 285:12321–12333
Schupp M, Lazar MA (2010) Endogenous ligands for nuclear receptors: digging deeper. J Biol Chem 285:40409–40415
Shaw N, Elholm M, Noy N (2003) Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem 278:41589–41592
Sohda T, Mizuno K, Tawada H, Sugiyama Y, Fujita T, Kawamatsu Y (1982a) Studies on antidiabetic agents I: synthesis of 5-[4-(2-methyl-2-phenylpropoxy)-benzyl]thiazolidine-2,4-dione (AL-321) and related compounds. Chem Pharm Bull(Tokyo) 30:3563–3573
Sohda T, Mizuno K, Imamiya A, Sugiyama Y, Fujita T, Kawamatsu Y (1982b) Studies on antidiabetic agents II: synthesis of 5-[4-(1-methylcyclohexyl methoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives. Chem Pharm Bull(Tokyo) 30:3580–3600
Sohda T, Momose Y, Meguro K, Kawamatsu Y, Sugiyama Y, Ikeda H (1990) Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy) benzyl]-2,4-thiazolidinediones. Arzneimitteleforschung 40:37–42
Sun Y, Alexander SP, Kendall DA, Bennett AJ (2006) Cannabinoids and PPARalpha signaling. Biochem Soc Trans 34:1095–1097
Throp JM, Waring WS (1962) Modification of metabolism and distribution of lipids by ethyl chlorophenoxyisobutyrate. Nature 194:948–949
Tsukahara T, Tsukahara R, Fujiwara Y, Yue J, Cheng Y, Guo H, Bolen A, Zhang C, Balazs L, Re F, Du G, Frohman MA, Baker DL, Parrill AL, Uchiyama A, Kobayashi T, Murakami-Murofushi K, Tigyi G (2010) Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid. Mol Cell 39:421–432
Varga T, Czimmerer Z, Nagy L (2011) PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta 1812:1007–1022
Waku T, Shiraki T, Oyama T, Maebara K, Nakamori R, Morikawa K (2010) The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites. EMBO J 29:3395–3407
Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM (2003) Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113:159–170
Watkins PB, Whitcomb RW (1998) Hepatic dysfunction associated with troglitazone. N Engl J Med 338:916–917
Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J (2003) Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci USA 100:2730–2735
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Youssef, J.A., Badr, M.Z. (2013). PPAR Ligands. In: Peroxisome Proliferator-Activated Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-420-3_4
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DOI: https://doi.org/10.1007/978-1-62703-420-3_4
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