Abstract
Nuclear receptors (NRs) are a large family of transcription factors activated by lipophilic hormones, vitamins, dietary lipids, and other intracellular signals (Evans 1988, 2004; Nagy and Schwabe 2004; Sonoda et al. 2008). These receptors regulate numerous metabolic pathways and processes in various organs, rendering them as valuable potential targets for the development of therapeutic agents against a multitude of conditions and diseases. In insects, the existence of the ecdysone receptor (EcR), a member of the nuclear receptor superfamily which is activated by the ecdysteroid molting hormones, has allowed the development of nonsteroidal EcR agonists that disrupt molting and can thus be used as safe pesticides (Fahrbach et al. 2011).
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Youssef, J.A., Badr, M.Z. (2013). Introduction. In: Peroxisome Proliferator-Activated Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-420-3_1
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DOI: https://doi.org/10.1007/978-1-62703-420-3_1
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Publisher Name: Humana Press, Totowa, NJ
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