Abstract
Exercise is generally thought to have a positive effect on bone; numerous studies indicate that bone mass is increased with training. Increasing physical activity levels throughout the life-span has been recommended for preventing the development of osteoporosis [1]. It has become evident, however, that too much exercise in combination with deficient energy intake may be detrimental to bone in some individuals. This may be owing to hormonal changes that occur when the body attempts to conserve energy or when an individual is under excess stress.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Blimkie CJR, Chilibeck PD, Davison KS. Bone mineralization patterns: reproductive endocrine, calcium and physical activity influences during the lifespan. In: Bar-Or O, Lamb D, Clarkson P, editors. Perspectives in exercise science and sports medicine: exercise and the female—a life span approach, vol. 9. Carmel, NJ: Cooper Publishing; 1996. p. 73–145.
Heaney RP, Recher RR, Stegman MR, Moy AJ. Calcium absorption in women: relationship to calcium intake, estrogen status and age. J Bone Miner Res. 1989;4:469–75.
Yeh JK, Liu CC, Aloia JF. Additive effect of treadmill exercise and 17 beta-estradiol replacement on prevention of tibial bone loss in adult oveariectomized rat. J Bone Miner Res. 1993;8:677–83.
Prior JC. Progesterone as a bone-trophic hormone. Endocr Rev. 1990;11:386–98.
Drinkwater BL, Nilson K, Chesnut CH, Bremner WJ, Shainholtz S, Southworth MB. Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med. 1984;311:277–81.
Robinson TL, Snow-Harter C, Taaffe CR, Gillis D, Shaw J, Marcus R. Gymnasts exhibit higher bone mass than runners despite similar prevalence of amenorrhea and oligomenorrhea. J Bone Miner Res. 1995;10:26–35.
Wolman RL, Clark P, McNally E, Harries M, Reeve J. Menstrual state and exercise as determinants of spinal trabecular bone density in female athletes. BMJ. 1990;301:516–8.
Slemenda C, Johnston CC. High impact activities in young women: site-specific bone mass effects among female figure skaters. Bone Miner. 1993;20:125–32.
Warren MP, Brooks-Gunn J, Fox RP, Lancelot C, Newman D, Hamilton WG. Lack of bone accretion and amenorrhea: evidence for a relative osteopenia in weight-bearing bones. J Clin Endocrinol Metab. 1991;72:847–53.
Fehling PC, Alekel L, Clasey J, Rector A, Stillman RJ. A comparison of bone mineral densities among female athletes in impact loading and active loading sports. Bone. 1995;17:205–10.
Young N, Formica C, Szmukler G, Seeman E. Bone density at weight-bearing and nonweight-bearing sites in ballet dancers: the effects of exercise, hypogonadism, and body weight. J Clin Endocrinol Metab. 1994;78:449–54.
Warren MP, Brooks-Gunn J, Hamilton LH, Warren LF, Hamilton WG. Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea. N Engl J Med. 1986;314:1348–53.
Rencken ML, Chesnut CH, Drinkwater BL. Bone density at multiple skeletal sites in amenorrheic athletes. JAMA. 1996;276:238–40.
Marcus R, Cann C, Madvig P, Minkoff J, Goddard M, Bayer M, et al. Menstrual function and bone mass in elite women distance runners. Ann Intern Med. 1985;102:158–63.
Myburgh KH, Hutchins J, Fataar AB, Hough SF, Noakes TD. Low bone density is an etiologic factor for stress fractures in athletes. Ann Intern Med. 1990;113:754–9.
Loucks AB, Verdun M, Heath EM. Low energy availability, not stress of exercise, alters LH pulsatility in exercising women. J Appl Physiol. 1998;84:37–46.
Harber VJ, Petersen SR, Chilibeck PD. Thyroid hormone concentrations and muscle metabolism in amenorrheic and eumenorrheic athletes. Can J Appl Physiol. 1998;23:293–306.
Wilmore JH, Wambscans KC, Brenner M, Broeder CE, Paijmans I, Volpe JA, et al. Is there energy conservation in amenorrheic compared with eumenorrheic distance runners? J Appl Physiol. 1992;72:15–22.
Loucks AB, Laughlin GA, Mortola JF, Girton L, Nelson JC, Yen SSC. Hypothalamic–pituitary–thyroidal function in eumenorrheic and amenorrheic athletes. J Clin Endocrinol Metab. 1992;75:514–8.
Harber VJ, Petersen SR, Chilibeck PD. Thyroid hormone concentrations and skeletal muscle metabolism during exercise in anorexic females. Can J Physiol Pharmacol. 1997;75:1197–202.
Ding J, Sheckter CB, Drinkwater BL, Soules M, Bremner WJ. High serum cortisol levels in exercise-associated amenorrhea. Ann Intern Med. 1988;108:530–4.
Loucks AB, Mortola JF, Girton L, Yen SSC. Alterations in the hypothalamic–pituitary–ovarian and the hypothalamic–pituitary–adrenal axes in athletic women. J Clin Endocrinol Metab. 1989;68:402–11.
Mann DR, Jackson GG, Blank MS. Influence of adrenocoritcotropin and adrenalectomy on gonadotropin secretion in immature rats. Neuroendocrinology. 1982;34:20–6.
Olster DH, Ferin M. Corticotropin-releasing hormone inhibits gonadotropin secretion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab. 1987;65:262–7.
Drinkwater BL, Nilson K, Ott S, Chesnut CH. Bone mineral density after resumption of menses in amenorrheic athletes. JAMA. 1986;256:380–2.
Linberg JS, Powell RR, Hunt MM, Ducey DE, Wade CE. Increased vertebral bone mineral in response to reduced exercise in amenorrheic runners. West J Med. 1987;146:39–42.
Cumming DC. Exercise-associated amenorrhea, low bone density, and estrogen replacement therapy. Arch Intern Med. 1996;56:2193–5.
Jonnavithula S, Warren MP, Fox RP, Lazaro MI. Bone density is compromised in amenorrheic women despite return of menses: a 2-year study. Obstet Gynecol. 1993;81:669–74.
Keen AD, Drinkwater BL. Irreversible bone loss in former amenorrheic athletes. Osteoporois Int. 1993;7:311–5.
Wheeler GD, Wall SR, Belcastro AN, Cumming DC. Reduced serum testosterone and prolactin levels in male distance runners. JAMA. 1984;252:514–6.
Strauss RH, Lanese RR, Malarkey WB. Weight loss in amateur wrestlers and its effect on serum testosterone levels. JAMA. 1985;254:3337–8.
Hope WG, Ibarra MJ, Thomas ML. Testosterone alters duodenal calcium transport and longitudinal bone growth rate in parallel in the male rat. Proc Soc Exp Biol Med. 1992;200:536–41.
Kasperk CH, Wergedal JE, Farley JR, Linkhart TA, Turner RT, Baylink DJ. Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology. 1989;124:1576–8.
Cumming DC, Quigley ME, Yen SS. Acute suppression of circulating testosterone levels by cortisol in men. J Clin Endocrinol Metab. 1983;57:671–3.
Gambacciani M, Yen SS, Rasmussen DD. GnRH release from the mediobasal hyothalamus: in vitro inhibition by corticotropin-releasing factor. Neuroendocrinology. 1986;43:533–6.
Hetland ML, Haarbo J, Christinsen C. Low bone mass and high bone turnover in male long distance runners. J Clin Endocrinol Metab. 1993;77:770–5.
MacDougall JD, Webber CE, Martin J, Ormerod S, Chesley A, Younglai EV, et al. Relationship among running mileage, bone density, and serum testosterone in male runners. J Appl Physiol. 1992;73:1165–70.
Burge MR, Lanzi RA, Skarda ST, Eaton RP. Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate. Fertil Steril. 1997;67:783–5.
McSheehy PM, Chambers TJ. Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoblastic bone resorption. Endocrinology. 1986;119:1654–9.
Ljunghall S, Joborn H, Roxin LE, Skarfors WT, Wide LE, Lithell HO. Increase in serum parathyroid hormone levels after prolonged physical exercise. Med Sci Sports Exerc. 1988;20:122–5.
Aloia JF, Rasulo P, Deftos LJ, Vaswani A, Yeh JK. Exercise-induced hypercalcemia and the calciotropic hormones. J Lab Clin Med. 1985;106:229–32.
Grimston SK, Tanguay KE, Gundberg CM, Hanley DA. The calciotropic hormone response to changes in serum calcium during exercise in female long distance runners. J Clin Endocrinol Metab. 1993;76:867–72.
Hodsman AB, Fraher LJ, Ostbye T, Adachi JD, Steer BM. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. J Clin Invest. 1993;91:1138–48.
Dempster DW, Cosman F, Parisien M, Shen B, Lindsay R. Anabolic actions of parathyroid hormone on bone. Endocr Rev. 1993;14:690–709.
Brown EM, Hurwitz S, Aurbach GD. Beta adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells. Endocrinology. 1977;100:1609–702.
Salvesen H, Johansson AG, Foxdal P, Wide L, Piehl-Aulin K, Ljunghall S. Intact serum parathyroid hormone levels increase during running exercise in well-trained men. Calcif Tissue Int. 1994;54:256–61.
Rockwell JC, Sorensen AM, Baker S, Leahey D, Stock JL, Michaels J, et al. Weight training decreases vertebral bone density in premenopausal women: a prospective study. J Clin Endocrinol Metab. 1990;71:988–93.
Bloomfield SA, Mysiw WJ, Jackson RD. Bone mass and endocrine adaptations to training in spinal cord injured individuals. Bone. 1996;19:61–8.
Nelson ME, Fiaterone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. JAMA. 1994;272:1909–14.
Boucher A, D’Amour P, Hamel L, Fugere P, Gascon-Barre M, Lepage R, et al. Estrogen replacement decreases the set point of parathyroid hormone stimulation by calcium in normal postmenopausal women. J Clin Endocrinol Metab. 1989;68:831–6.
Kohrt WM, Snead DB, Slatopolsky E, Birge J. Additive effects of weight-bearing exercise and estrogen on bone mineral density in older women. J Bone Miner Res. 1995;10:1303–11.
Notelovitz M, Martin D, Tesar R, Khan FY, Probart C, Fields C, et al. Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women. J Bone Miner Res. 1991;6:583–9.
Cheng MZ, Zaman G, Rawlinson SCF, Suswillo RFL, Lanyon LE. Mechanical loading and sex hormone interactions in organ cultures of rat ulna. J Bone Miner Res. 1996;11:502–11.
Mathews LS, Norstedt G, Palmiter RD. Regulation of insulin-like growth factor 1 gene expression by growth hormone. Proc Natl Acad Sci USA. 1986;83:9343–7.
Kassem M, Blum W, Risteli J, Mosekilde L, Eriksen EF. Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int. 1993;52:222–6.
Schmid C, Guler HP, Rowe D, Froesch ER. Insulin-like growth factor I regulates type 1 procollagen messenger ribonucleic acid steady state levels in bone of rats. Endocrinology. 1989;125:1575–80.
Kraemer RR, Kilgore JL, Kraemer GR, Castracane VD. Growth hormone, IGF-1 and testosterone responses to resistive exercise. Med Sci Sports Exerc. 1992;24:1346–52.
Craig BW, Brown R, Everhart J. Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech Ageing Dev. 1989;49:159–69.
Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol. 1990;69:1442–50.
Cumming DC, Brunsting LA, Strich G, Ries AL, Rebar RW. Reproductive hormone increases in response to acute exercise in men. Med Sci Sports Exerc. 1986;18:369–73.
Cappon J, Brasel JA, Mohan S, Cooper DM. Effect of brief exercise on circulating insulin-like growth factor 1. J Appl Physiol. 1994;76:2490–6.
Cumming DC, Wall SR, Galbraith MA, Belcastro AN. Reproductive hormone responses to resistance exercise. Med Sci Sports Exerc. 1987;19:234–8.
Kraemer RR, Heleniak RJ, Tryniecki JL, Kraemer GR, Okazaki NJ, Castracane VD. Follicular and luteal phase hormonal responses to low-volume resistive exercise. Med Sci Sports Exerc. 1995;27:809–17.
Kraemer WJ, Gordon SE, Fleck SJ, Marchitelli LJ, Mello R, Dziados JE, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 1991;12:228–35.
Brahm H, Pielhl-Aulin K, Saltin B, Ljunghall S. Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise. Calcif Tissue Int. 1997;60:175–80.
Davee AM, Rosen CJ, Adler RA. Exercise patterns and trabecular bone density in college women. J Bone Miner Res. 1990;5:245–50.
Buchanan JR, Myers C, Lloyd T, Leuenberger P, Demers LM. Determinants of peak trabecular bone density in women: the role of androgens, estrogen, and exercise. J Bone Miner Res. 1988;3:673–80.
Nelson ME, Meredith CN, Dawson-Hughes B, Evans WJ. Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women. J Clin Endocrinol Metab. 1988;66:927–33.
Hakkinen K, Pakarinen A, Alen M, Kauhanen H, Komi PV. Neuromuscular and hormonal adaptations in athletes to strength training in two years. J Appl Physiol. 1988;65:2406–12.
Gotshalk LA, Loebel CC, Nindl BD, Putukian M, Sebastianelli WJ, Newton RU, et al. Hormonal responses of multiset versus single-set heavy-resistance exercise protocols. Can J Appl Physiol. 1997;22:244–55.
Calder AW, Chilibeck PD, Webber CE, Sale DG. Comparison of whole and split weight training routines in young women. Can J Appl Physiol. 1994;19:185–99.
Chilibeck PD, Calder A, Sale DG, Webber CE. Twenty weeks of weight training increases lean tissue mass but not bone mineral mass or density in healthy, active young women. Can J Physiol Pharmacol. 1996;74:1180–5.
Vanhelder WP, Radomeski MW, Goode RC. Growth hormone responses during intermittent weight lifting exercise in men. Eur J Appl Physiol. 1984;53:31–4.
Kerr D, Morton A, Dick I, Prince R. Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res. 1996;11:218–25.
Ryan AS, Treuth MS, Rubin MA, Miller JP, Nicklas BJ, Landis DM, et al. Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol. 1994;77:1678–84.
Nichols DL, Sanborn CF, Bonnick SL, Ben-Ezra V, Gench B, DiMarco NM. The effects of gymnastics training on bone mineral density. Med Sci Sports Exerc. 1994;26:1220–5.
Yeh JK, Aloia JF, Chen M, Ling N, Koo H-C, Millard WJ. Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-1 in rats. Am J Physiol. 1994;266:E129–35.
Brahm H, Strom H, Piehl-Aulin K, Mallmin H, Ljunghall S. Bone metabolism in endurance trained athletes: a comparison to population-based controls based on DXA, SXA, quantitative ultrasound, and biochemical markers. Calcif Tissue Int. 1997;61:448–54.
Yeh JK, Aloia JF. Effect of physical activity on calciotropic hormones and calcium balance in rats. Am J Physiol. 1990;258:E263–8.
Bell NH, Godsen RN, Henry DP, Shary J, Epstein S. The effects of muscle-building exercise on vitamin D and mineral metabolism. J Bone Miner Res. 1988;3:369–73.
Colletti LA, Edwards J, Gordon L, Shary J, Bell NH. The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men. Calcif Tissue Int. 1989;45:12–4.
Yeh JK, Aloia JF, Yasumura S. Effect of physical activity on calcium and phosphorus metabolism in the rat. Am J Physiol. 1989;256:E1–6.
Spanos D, Barett D, MacIntyre I, Pike JW, Safilian EF, Houssler MR. Effect of growth hormone on vitamin D metabolism. Nature. 1978;273:246–7.
Shangold M, Rebar RW, Colston A, Schiff I. Evaluation and management of menstrual dysfunction in athletes. JAMA. 1990;263:1665–9.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Chilibeck, P.D. (2013). Hormonal Regulations of the Effects of Exercise on Bone: Positive and Negative Effects. In: Constantini, N., Hackney, A. (eds) Endocrinology of Physical Activity and Sport. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-314-5_14
Download citation
DOI: https://doi.org/10.1007/978-1-62703-314-5_14
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-313-8
Online ISBN: 978-1-62703-314-5
eBook Packages: MedicineMedicine (R0)