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Role of Nitric Oxide in Neurological Disorders

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Applications of Biotechnology in Neurology

Abstract

Although one of the simplest biological molecules in nature, nitric oxide (NO) has found its way into nearly every phase of biology and medicine, ranging from its role as a critical endogenous regulator of blood flow and thrombosis to a principal neurotransmitter mediating erectile function as well as a major pathophysiological mediator of inflammation and host defense. Role of NO in physiology, pathology, pharmacology andhuman therapeutics has been described in detail in a special report on the topic (Jain 2012).

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References

  • Bath PM, Willmot M, Leonardi-Bee J, Bath FJ. Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. Cochrane Database Syst Rev 2002; CD000398.

    Google Scholar 

  • Bennett BM, Reynolds JN, Prusky GT, et al. Cognitive Deficits in Rats after Forebrain Cholinergic Depletion are Reversed by a Novel NO Mimetic Nitrate Ester. Neuropsychopharmacology 2007;32:505-13.

    Article  PubMed  CAS  Google Scholar 

  • Brunelli S, Sciorati C, D’Antona G, et al. Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. PNAS 2007;104:264-9.

    Article  PubMed  CAS  Google Scholar 

  • Brunori M, Vallone B. A globin for the brain. FASEB J 2006;20:2192-7.

    Article  PubMed  CAS  Google Scholar 

  • Casado B, Pannell LK, Whalen G, et al. Human neuroglobin protein in cerebrospinal fluid. Proteome Sci 2005;3:2

    Article  PubMed  Google Scholar 

  • Cherian L, Hlatky R, Robertson CS. Nitric oxide in traumatic brain injury. Brain Pathol 2004;14:195-201.

    Article  PubMed  CAS  Google Scholar 

  • Choi JY, Park CS, Kim DJ, et al. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology 2002;23:367-74.

    Article  PubMed  CAS  Google Scholar 

  • Cocchiarella A. Partial motor restoration upon administration of sildenafil: a case study. Dev Neurorehabil 2012;15:39-43.

    Article  PubMed  Google Scholar 

  • Conti G, Rostami AM, Scarpini E, et al. iNOS induction in rat peripheral nervous system during EAN. Neurology 2003 March;60 (suppl 1): A385-386.

    Google Scholar 

  • Costa C, Tozzi A, Siliquini S, et al. A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide. Neurobiol Dis 2011;44:185-91.

    Article  PubMed  CAS  Google Scholar 

  • ENOS Trial Investigators. Glyceryl trinitrate versus control, and continuing versus stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the efficacy of nitric oxide in Stroke (ENOS) trial. Int J Stroke 2006;1:245–9.

    Google Scholar 

  • Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin 2010;26:1715-31.

    Article  PubMed  CAS  Google Scholar 

  • Gu Y, Zheng G, Xu M, et al. Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem 2012;120:147-56.

    Article  PubMed  CAS  Google Scholar 

  • Jain KK. Textbook of Hyperbaric Medicine, 5th ed. Hogrefe, Göttingen, 2009.

    Google Scholar 

  • Jain KK. Drug-induced Neurological Disorders, 5th ed. Hogrefe, Göttingen, 2011.

    Google Scholar 

  • Jain KK. Handbook of Neuroprotection. Springer, New York, 2011a.

    Book  Google Scholar 

  • Jain KK. Nitric Oxide: technologies, markets & companies. Jain PharmaBiotech Publications, Basel, 2012.

    Google Scholar 

  • Jain KK. Pain: Drugs, Markets and Companies. Basel, Jain PharmaBiotech Publications, 2012a.

    Google Scholar 

  • Jain KK. Zonisamide. In Gilman S (ed) MedLink Neurology. Medlink Publishing Corporation, San Diego, California, 2012b.

    Google Scholar 

  • Khan AA, Wang Y, Sun Y, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A 2006;103:17944-8.

    Article  PubMed  CAS  Google Scholar 

  • Khurana VG, Meissner I, Sohni YR, et al. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 2005;102:526-31.

    Article  PubMed  CAS  Google Scholar 

  • Lee Y, Shin T. Expression of constitutive endothelial and inducible nitric oxide synthase in the sciatic nerve of Lewis rats with experimental autoimmune neuritis. J Neuroimmunol 2002;126:78-85.

    Article  PubMed  CAS  Google Scholar 

  • L’Episcopo F, Tirolo C, Caniglia S, et al. Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease. J Neuroinflammation 2010;7:83.

    Article  PubMed  Google Scholar 

  • Li J, Baud O, Vartanian T, et al. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. PNAS 2005;102:9936-41.

    Article  PubMed  CAS  Google Scholar 

  • Liu L, Huq S, Xu W. Targeting cyclooxygenase and nitric oxide pathway cross-talk: a new signal transduction pathway for developing more effective anti-inflammatory drugs. Current Signal Transduction Therapy 2009;4:66-75.

    Article  CAS  Google Scholar 

  • Mariucci G, Taha E, Tantucci M, et al. Intravenous administration of pravastatin immediately after middle cerebral artery occlusion reduces cerebral oedema in spontaneously hypertensive rats. Eur J Pharmacol 2011;660:381-6.

    Article  PubMed  CAS  Google Scholar 

  • Marks JD, Schreiber MD. Inhaled nitric oxide and neuroprotection in preterm infants. Clin Perinatol 2008;35:793-807.

    Article  PubMed  Google Scholar 

  • Nathan C, Calingasan N, Nezezon J, et al. Protection from Alzheimer’s-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med 2005;202:1163-9.

    Article  PubMed  CAS  Google Scholar 

  • Olesen J. The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache. Pharmacol Ther 2008;120:157-71.

    Article  PubMed  CAS  Google Scholar 

  • Onozawa T, Atsuta Y, Sato M, et al. Nitric oxide induced ectopic firing in a lumbar nerve root with cauda equina compression. Clin Orthop 2003;408:167-73.

    Article  PubMed  Google Scholar 

  • Pitsikas N, Rigamonti A, Cella SG, et al. The nitric oxide donor molsidomine antagonizes age-related memory deficits in the rat. Neurobiology of Aging 2005;26:259-64.

    Article  PubMed  CAS  Google Scholar 

  • Pluta RM, Dejam A, Grimes G, et al. Nitrite Infusions to Prevent Delayed Cerebral Vasospasm in a Primate Model of Subarachnoid Hemorrhage. JAMA 2005;293:1477-84.

    Article  PubMed  CAS  Google Scholar 

  • Pradilla G, Thai QA, Legnani FG, et al. Delayed Intracranial Delivery of a Nitric Oxide Donor from a Controlled-release Polymer Prevents Experimental Cerebral Vasospasm in Rabbits. Neurosurgery 2004;55:1393-400.

    Article  PubMed  Google Scholar 

  • Reif A, Grünblatt E, Herterich S, et al. Association of a functional NOS1 promoter repeat with Alzheimer’s disease in the VITA cohort. J Alzheimers Dis 2011;23:327-33.

    PubMed  CAS  Google Scholar 

  • Reinert M, Wiest R, Barth L, et al. Transdermal nitroglycerin in patients with subarachnoid hemorrhage. Neurol Res 2004;26:435-9.

    Article  PubMed  CAS  Google Scholar 

  • Sardo P, Ferraro G. Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat. BMC Neuroscience 2007;8:47.

    Article  PubMed  Google Scholar 

  • Sehba FA, Chereshnev I, Maayani S, et al. Nitric oxide synthase in acute alteration of nitric oxide levels after subarachnoid hemorrhage. Neurosurgery 2004;55:671-8.

    Article  PubMed  Google Scholar 

  • Shin HK, Salomone S, Potts EM, et al. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab 2007;27:998-1009

    PubMed  CAS  Google Scholar 

  • Srinivasan K, Sharma SS. 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP. Life Sci 2012;90:154-60.

    Article  PubMed  CAS  Google Scholar 

  • Steinert JR, Chernova T, Forsythe ID. Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 2010;16:435-52.

    Article  PubMed  CAS  Google Scholar 

  • Stern M, Bicker G. Nitric oxide regulates axonal regeneration in an insect embryonic CNS. Dev Neurobiol 2008;68:295-308.

    Article  PubMed  CAS  Google Scholar 

  • Tan KH, Harrington S, Purcell WM, Hurst RD. Peroxynitrite mediates nitric oxide-induced blood-brain barrier damage. Neurochem Res 2004;29:579-87.

    Article  PubMed  CAS  Google Scholar 

  • Terpolilli NA, Moskowitz MA, Plesnila N. Nitric oxide: considerations for the treatment of ischemic stroke. J Cereb Blood Flow Metab 2012;32:1332-46.

    Article  PubMed  CAS  Google Scholar 

  • Terpolilli NA, Zweckberger K, Trabold R, et al. The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice. J Neurotrauma 2009;26:1963-75.

    Article  PubMed  Google Scholar 

  • Wang H, Hitron IM, Iadecola C, Pickel VM. Synaptic and Vascular Associations of Neurons Containing Cyclooxygenase-2 and Nitric Oxide Synthase in Rat Somatosensory Cortex. Cereb Cortex 2005;15:1250-60.

    Article  PubMed  Google Scholar 

  • Willmot M, Gibson C, Gray L, et al. Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: A systematic review. Free Radic Biol Med 2005b;39:412-25.

    Article  PubMed  CAS  Google Scholar 

  • Willmot M, Gray L, Gibson C, et al. A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow. Nitric Oxide 2005a;12:141-9.

    Article  PubMed  CAS  Google Scholar 

  • Yang ZX, Qin J. Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of recurrent febrile seizures. Biochem Biophys Res Commun 2004;315:349-55.

    Article  PubMed  CAS  Google Scholar 

  • Yuen KC, Baker NR, Rayman G.Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray: a double-blind placebo-controlled cross-over study. Diabetes Care 2002;25:1699-703.

    Article  PubMed  CAS  Google Scholar 

  • Zhang R, Wang L, Zhang L, et al. Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res 2003;92:308-13.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain MD, FRACS, FFPM

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  1. Kewal K. Jain MD, FRACS, FFPM
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Jain, K.K. (2013). Role of Nitric Oxide in Neurological Disorders. In: Applications of Biotechnology in Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-272-8_8

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