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Pro- and Prebiotics for the Prevention and Treatment of Diseases in Childhood

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Nutrition in Infancy

Part of the book series: Nutrition and Health ((NH))

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Abstract

Children have ten times more microbial than body cells. Most of them are located within the gastrointestinal tract, the so-called gut microbiota. So far, more than 500 different species have been identified with microbiological techniques. However, there are probably many more as might soon be revealed by the Human Microbiome Project (HMP), which was started in 2007 by the National Institute of Health employing new molecular technologies, such as meta-genomics and high-throughout sequencing which no longer require traditional cell culture. The human microbiome is the collective genome of all microorganisms present in the human body and on its surface. Remarkable differences in the microbiota of human beings have already been shown. One of the goals of the HMP was to understand whether changes in the human microbiome are associated with changes in health status.

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References

  1. Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010;328(5975):228–31.

    Article  PubMed  CAS  Google Scholar 

  2. Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, Louis P, et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). 2008;32(11):1720–4.

    Article  CAS  Google Scholar 

  3. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature. 2008;455(7216):1109–13.

    Article  PubMed  CAS  Google Scholar 

  4. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57–63.

    Article  PubMed  CAS  Google Scholar 

  5. Food and Agriculture Organisation of the United Nations; World Health Organisation. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. 2001. http://www.who.int/foodsafety/publications/fs_management/en/probiotics.pdf. Accessed Dec 2011.

    Google Scholar 

  6. Food and Agriculture Organisation of the United Nations; World Health Organisation. Guidelines for the evaluation of probiotics in food: joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. 2002. ftp://ftp.fao.org/es/esn/food/wgreport2.pdf Accessed Dec 2011.

    Google Scholar 

  7. Council for Agricultural Science and Technology. Probiotics: their potential to impact human health. Ames, IA: Council for Agricultural Science and Technology; 2007. http://www.cast-science.org/websiteUploads/publciationPDFs/CAST%20Probiotics%20Issue%20Paper%20FINAL144.pdf.AccessedDec2011

    Google Scholar 

  8. Ruemmele FM, Bier D, Marteau P, Rechkemmer G, Bourdet-Sicard R, Walker WA, et al. Clinical evidence for immunomodulatory effects of probiotic bacteria. J Pediatr Gastroenterol Nutr. 2009;48(2):126–41.

    Article  PubMed  CAS  Google Scholar 

  9. Bjorkstein B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999;29(3):342–6.

    Article  Google Scholar 

  10. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro-and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer. 2005;51(1):102–9.

    Article  PubMed  CAS  Google Scholar 

  11. Roberfroid M. Prebiotics; the concept revisited. J Nutr. 2007;137(3 suppl 2):830S–7.

    PubMed  CAS  Google Scholar 

  12. Grönlund MM, Gueimonde M, Laitinen K, et al. Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin Exp Allergy. 2007;37(12):1764–72.

    Article  PubMed  Google Scholar 

  13. Perez PF, Doré J, Leclerc M, Levenez F, Benyacoub J, Serrant P, et al. Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics. 2007;119(3):e724–32.

    Article  PubMed  Google Scholar 

  14. Díaz-Ropero MP, Martín R, Sierra S, Lara-Villoslada F, Rodríguez JM, Xaus J, et al. Two Lactobacillus strains, isolated from breast milk, differently modulate the immune response. J Appl Microbiol. 2007;102(2):337–43.

    Article  PubMed  Google Scholar 

  15. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatr Res. 2011;69(6):465–72.

    Article  PubMed  Google Scholar 

  16. Fukushima Y, Kawata Y, Hara H, Terada A, Mitsuoka T. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol. 1998;42(1–2):39–44.

    Article  PubMed  CAS  Google Scholar 

  17. Rautava S, Arvilommi H, Isolauri E. Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Pediatr Res. 2006;60(2):221–4.

    Article  PubMed  Google Scholar 

  18. Holscher HD, Czerkies LA, Cekola P, Litov R, Benbow M, Santema S, et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. J Parenter Enteral Nutr. 2012;36:106S–17.

    Article  CAS  Google Scholar 

  19. Braegger C, Chmielewska A, Decsi T, Kolacek S, Mihatsch W, Moreno L, et al. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr. 2011;52(2):238–50.

    Article  PubMed  Google Scholar 

  20. Thomas DW, Greer FR; American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Gastroenterology, Hepatology, and Nutrition. Probiotics and prebiotics in pediatrics. Pediatrics. 2010;126(6):1217–31.

    Google Scholar 

  21. Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994;344(8929):1046–9.

    Article  PubMed  CAS  Google Scholar 

  22. Chouraqui JP, Van Egroo LD, Fichot MC. Acidified milk formula supplemented with bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr. 2004;38(3):288–92.

    Article  PubMed  Google Scholar 

  23. Corrêa NB, Péret Filho LA, Penna FJ, Lima FM, Nicoli JR. A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol. 2005;39(5):385–9.

    Article  PubMed  Google Scholar 

  24. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005;115(1):5–9.

    PubMed  Google Scholar 

  25. Maldonado J, Lara-Villoslada F, Sierra S, Sempere L, Gómez M, Rodriguez JM, et al. Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children. Nutrition. 2010;26(11–12):1082–7.

    Article  PubMed  Google Scholar 

  26. Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhea. Int J Clin Pract. 2000;54(9):568–71.

    PubMed  CAS  Google Scholar 

  27. Szajewska H, Kotowska M, Mrukowicz JZ, Armańska M, Mikołajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr. 2001;138(3):361–5.

    Article  PubMed  CAS  Google Scholar 

  28. Guandalini S, Pensabene L, Zikri MA, Dias JA, Casali LG, Hoekstra H, et al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr. 2000;30(1):54–60.

    Article  PubMed  CAS  Google Scholar 

  29. Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2010;11:CD003048.

    Google Scholar 

  30. Shornikova AV, Casas IA, Isolauri E, Mykkänen H, Vesikari T. Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. J Pediatr Gastroenterol Nutr. 1997;24(4):399–404.

    Article  PubMed  CAS  Google Scholar 

  31. Shornikova AV, Casas IA, Mykkänen H, Salo E, Vesikari T. Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis. Pediatr Infect Dis J. 1997;16(12):1103–7.

    Article  PubMed  CAS  Google Scholar 

  32. Eom TH, Oh EY, Kim YH, Lee HS, Jang PS, Kim DU, Kim JT, Lee BC. The therapeutic effects of Lactobacillus reuteri in acute diarrhea in infants and toddlers. Korean J Ped. 2005;48:986–90.

    Google Scholar 

  33. Bernaola Aponte G, Bada Mancilla CA, Carreazo Pariasca NY, Rojas Galarza RA. Probiotics for treating persistent diarrhoea in children. Cochrane Database Syst Rev. 2010;11:CD007401.

    Google Scholar 

  34. Brown KH, Perez F, Peerson JM, Fadel J, Brunsgaard G, Ostrom KM, et al. Effect of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery diarrhea in children. Pediatrics. 1993;92(2):241–7.

    PubMed  CAS  Google Scholar 

  35. Moore N, Chao C, Yang LP, Storm H, Oliva-Hemker M, Saavedra JM. Effects of fructo-oligosaccharide-supplemented infant cereal: a double-blind, randomized trial. Br J Nutr. 2003;90(3):581–7.

    Article  PubMed  CAS  Google Scholar 

  36. Arslanoglu S, Moro GE, Boehm G. Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J Nutr. 2007;137(11):2420–4.

    PubMed  CAS  Google Scholar 

  37. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr. 2008;138(6):1091–5.

    PubMed  CAS  Google Scholar 

  38. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child. 2006;91(10):814–9.

    Article  PubMed  CAS  Google Scholar 

  39. Vandenplas Y, Veereman-Wauters G, De Greef E, Peeters S, Casteels A, Mahler T, et al. Probiotics and prebiotics in prevention and treatment of diseases in infants and children. J Pediatr (Rio J). 2011;87(4):292–300.

    Article  Google Scholar 

  40. Szajewska H, Ruszczyński M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr. 2006;149(3):367–72.

    Article  PubMed  Google Scholar 

  41. Johnston BC, Supina AL, Ospina M, Vohra S. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2007;2:CD004827.

    Google Scholar 

  42. Kale-Pradhan PB, Jassal HK, Wilhelm SM. Role of Lactobacillus in the prevention of antibiotic-associated diarrhea: a meta-analysis. Pharmacotherapy. 2010;30(2):119–26.

    Article  PubMed  Google Scholar 

  43. Bergonzelli GE, Blum S, Brussow H, Corthésy-Theulaz I. Probiotics as a treatment strategy for gastrointestinal diseases? Digestion. 2005;72(1):57–68.

    Article  PubMed  Google Scholar 

  44. Felley CP, Corthésy-Theulaz I, Rivero JL, Sipponen P, Kaufmann M, Bauerfeind P, et al. Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol. 2001;13(1):25–9.

    Article  PubMed  CAS  Google Scholar 

  45. Lesbros-Pantoflickova D, Corthésy-Theulaz I, Blum AL. Helicobacter pylori and probiotics. J Nutr. 2007;137(3 Suppl 2):812S–8.

    PubMed  CAS  Google Scholar 

  46. Szajewska H, Horvath A, Piwowarczyk A. Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther. 2010;32(9):1069–79. doi:10.1111/j.1365-2036.2010.04457.x. Epub 2010 Sep 16.

    Article  PubMed  CAS  Google Scholar 

  47. Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53(2):230–43.

    PubMed  Google Scholar 

  48. Day AS, Whitten KE, Bohane TD. Use of complementary and alternative medicines by children and adolescents with inflammatory bowel disease. J Paediatr Child Health. 2004;40(12):681–4.

    Article  PubMed  CAS  Google Scholar 

  49. Heuschkel R, Afzal N, Wuerth A, Zurakowski D, Leichtner A, Kemper K, et al. Complementary medicine use in children and young adults with inflammatory bowel disease. Am J Gastroenterol. 2002;97(2):382–8.

    Article  PubMed  Google Scholar 

  50. Mallon P, McKay D, Kirk S, Gardiner K. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007;4:CD005573.

    Google Scholar 

  51. Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, et al. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology. 2003;124(5):1202–9.

    Article  PubMed  Google Scholar 

  52. Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, et al. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut. 2004;53(1):108–14.

    Article  PubMed  CAS  Google Scholar 

  53. Kuisma J, Mentula S, Jarvinen H, Kahri A, Saxelin M, Farkkila M. Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora. Aliment Pharmacol Ther. 2003;17(4):509–15.

    Article  PubMed  CAS  Google Scholar 

  54. Elahi B, Nikfar S, Derakhshani S, Vafaie M, Abdollahi M. On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials. Dig Dis Sci. 2008;53(5):1278–84.

    Article  PubMed  Google Scholar 

  55. Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009;104(2):437–43.

    Article  PubMed  CAS  Google Scholar 

  56. Guandalini S. Update on the role of probiotics in the therapy of pediatric inflammatory bowel disease. Expert Rev Clin Immunol. 2010;6(1):47–54.

    Article  PubMed  CAS  Google Scholar 

  57. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347(12):911–20.

    Article  PubMed  Google Scholar 

  58. van Nimwegen FA, Penders J, Stobberingh EE, Postma DS, Koppelman GH, Kerkhof M, et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol. 2011;128(5):948–55.

    Article  PubMed  Google Scholar 

  59. Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001;357(9262):1076–9.

    Article  PubMed  Google Scholar 

  60. Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003;361(9372):1869–71.

    Article  PubMed  Google Scholar 

  61. Kalliomäki M, Salminen S, Poussa T, Isolauri E. Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(4):1019–21.

    Article  PubMed  Google Scholar 

  62. Abrahamsson TR, Jakobsson T, Böttcher MF, Fredrikson M, Jenmalm MC, Björkstén B, et al. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(5):1174–80.

    Article  PubMed  CAS  Google Scholar 

  63. Taylor AL, Dunstan JA, Prescott SL. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol. 2007;119(1):184–91.

    Article  PubMed  Google Scholar 

  64. Zhu DL, Yang WX, Yang HM. Meta analysis of lactic acid bacteria as probiotics for the primary prevention of infantile eczema. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(9):734–9.

    PubMed  Google Scholar 

  65. Brunser O, Figueroa G, Gotteland M, Haschke-Becher E, Magliola C, Rochat F, et al. Effects of probiotic or prebiotic supplemented milk formulas on fecal microbiota composition of infants. Asia Pac J Clin Nutr. 2006;15(3):368–76.

    PubMed  CAS  Google Scholar 

  66. Haschke-Becher E, Brunser O, Cruchet S, Gotteland M, Haschke F, Bachmann C. Urinary D-lactate excretion in infants receiving Lactobacillus johnsonii with formula. Ann Nutr Metab. 2008;53(3–4):240–4.

    Article  PubMed  CAS  Google Scholar 

  67. Chouraqui JP, Grathwohl D, Labaune JM, Hascoet JM, de Montgolfier I, Leclaire M, et al. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am J Clin Nutr. 2008;87(5):1365–73.

    PubMed  CAS  Google Scholar 

  68. Vendt N, Grünberg H, Tuure T, Malminiemi O, Wuolijoki E, Tillmann V, et al. Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial. J Hum Nutr Diet. 2006;19(1):51–8.

    Article  PubMed  CAS  Google Scholar 

  69. Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr. 2006;83(6):1256–64; quiz 1446–7.

    Google Scholar 

  70. Saavedra JM, Abi-Hanna A, Moore N, Yolken RH. Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety. Am J Clin Nutr. 2004;79(2):261–7.

    PubMed  CAS  Google Scholar 

  71. Nopchinda S, Varavithya W, Phuapradit P, Sangchai R, Suthutvoravut U, Chantraruksa V, et al. Effect of bifidobacterium Bb12 with or without Streptococcus thermophilus supplemented formula on nutritional status. J Med Assoc Thai. 2002;85 Suppl 4:S1225–31.

    PubMed  Google Scholar 

  72. Velaphi SC, Cooper PA, Bolton KD, Mokhachane M, Mphahlele RM, Beckh-Arnold E, et al. Growth and metabolism of infants born to women infected with human immunodeficiency virus and fed acidified whey-adapted starter formulas. Nutrition. 2008;24(3):203–11.

    Article  PubMed  CAS  Google Scholar 

  73. Brunser O, Gotteland M, Cruchet S, Figueroa G, Garrido D, Steenhout P. Effect of a milk formula with prebiotics on the intestinal microbiota of infants after an antibiotic treatment. Pediatr Res. 2006;59(3):451–6.

    Article  PubMed  Google Scholar 

  74. Rao S, Srinivasjois R, Patole S. Prebiotic supplementation in full-term neonates: a systematic review of randomized controlled trials. Arch Pediatr Adolesc Med. 2009;163(8):755–64.

    Article  PubMed  Google Scholar 

  75. Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;4:CD006474.

    Google Scholar 

  76. Simakachorn N, Bibiloni R, Yimyaem P, Tongpenyai Y, Varavithaya W, Grathwohl D, et al. Tolerance, safety, and effect on the faecal microbiota of an enteral formula supplemented with pre- and probiotics in critically ill children. J Pediatr Gastroenterol Nutr. 2011;53(2):174–81.

    Article  PubMed  CAS  Google Scholar 

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Haschke-Becher, E., Haschke, F. (2013). Pro- and Prebiotics for the Prevention and Treatment of Diseases in Childhood. In: Watson, R., Grimble, G., Preedy, V., Zibadi, S. (eds) Nutrition in Infancy. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-254-4_21

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