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Carotenoid Metabolism and Health in Pregnancy and Lactation

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Carotenoids and Human Health

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Abstract

Carotenoids derived entirely from the mother are important sources of provitamin A for the fetus and the young infant, making adequate carotenoid intake in pregnancy and lactation critical.

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References

  1. Lietz G, Lange J, Rimbach G. Molecular and dietary regulation of beta, beta carotene 15, 15’-monooxygenase 1 (BCMO1). Arch Biochem Biophys. 2010;502:8–16.

    Article  PubMed  CAS  Google Scholar 

  2. Debier C, Larondelle Y. Vitamins A and E: metabolism, roles and transfer to offspring. Br J Nutr. 2005;93:153–74.

    Article  PubMed  CAS  Google Scholar 

  3. Wyss A. Carotene oxygenases, a new family of double bond cleavage enzymes. J Nutr. 2004;134:246S–50S.

    PubMed  CAS  Google Scholar 

  4. Marceau G, Gallot D, Lemery D, Sapin V. Metabolism of retinol during mammalian placental and embryonic development. Vitam Horm. 2007;75:97–115.

    Article  PubMed  CAS  Google Scholar 

  5. Sundaram M, Sivaprassadaro A, DeSousa MM, Findlay JB. The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor. J Biol Chem. 1998;273:3336–42.

    Article  PubMed  CAS  Google Scholar 

  6. Kawaguchi R, Yu J, Honda J, et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315:820–5.

    Article  PubMed  CAS  Google Scholar 

  7. Dimenstein R, Trugo NMF, Donangelo CM, et al. Effect of subadequate maternal vitamin A status on placental transfer of retinol and beta-carotene to the human fetus. Biol Neonate. 1998;69:230–4.

    Google Scholar 

  8. Gomes MM, Saunders C, Ramalho A. Placenta: a possible predictor of vitamin A deficiency. Br J Nutr. 2010;103:1340–4.

    Article  PubMed  CAS  Google Scholar 

  9. Scaife AR, McNeil G, Campbell DM, Matindale S, Devereux G, Seaton A. Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery. Br J Nutr. 2006;95:771–8.

    Article  PubMed  CAS  Google Scholar 

  10. De Barros Silva SS, Rondo PH, Erzinger GS. Beta-carotene concentrations in maternal and cord blood of smokers and non-smokers. Early Hum Dev. 2005;81:313–7.

    Article  PubMed  Google Scholar 

  11. Yamini S, West Jr KP, Wu L, Dreyfuss ML, Yang DX, Khatry SK. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Eur J Clin Nutr. 2001;55:252–9.

    Article  PubMed  CAS  Google Scholar 

  12. Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001.

    Google Scholar 

  13. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995–2005: WHO global database on vitamin A deficiency. 2009, WHO, Geneva. [online], http://www.who.int/vmnis/vitamina/prevalence/en/index.html.

  14. Christian P, West Jr KP, Khatry SK, et al. Night blindness of pregnancy in rural Nepal-nutritional and health risks. Int J Epidemiol. 1998;27:231–7.

    Article  PubMed  CAS  Google Scholar 

  15. Christian P, West Jr KP, Khatry SK. Maternal night blindness increases risk of mortality in the first 6 months of life among infants in Nepal. J Nutr. 2001;131:1510–2.

    PubMed  CAS  Google Scholar 

  16. Tanumihardjo SA, Palacios N, Pixley KV. Provitamin A carotenoid bioavailability: what really matters? Int J Vit Nutr Res. 2010;80:336–50.

    CAS  Google Scholar 

  17. Christian P, West Jr KP, Khatry SK, et al. Vitamin A or beta-carotene supplementation reduces but does not eliminate maternal night blindness in Nepal. J Nutr. 1998;128:1458–63.

    PubMed  CAS  Google Scholar 

  18. West KP Jr, Katz J, Khatry SK et al. Double blind, cluster randomized trial of low dose supplementation with vitamin A of beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ. 1999 27;318:570–5.

    Google Scholar 

  19. Katz J, West Jr KP, Khatry SK, Pradhan EK, LeClerq SC, Christian P, Wu LSF, Adhikari RK, Shrestha SR, Sommer A. Low-dose vitamin A or beta-carotene supplementation does not reduce early infant mortality: A double-masked, randomized, controlled community trial in Nepal. Am J Clin Nutr. 2000;71:1570–6.

    PubMed  CAS  Google Scholar 

  20. West Jr KP, Christian P, Labrique AB, et al. Effects of vitamin A or beta carotene supplementation on pregnancy-related mortality and infant mortality in rural Bangladesh: a cluster randomized trial. JAMA. 2011;305:1986–95.

    Article  PubMed  CAS  Google Scholar 

  21. Watson PE, McDonald BW. The association of maternal diet and dietary supplement intake in pregnant New Zealand women with infant birth weight. Eur J Clin Nutr. 2010;64:184–93.

    Article  PubMed  CAS  Google Scholar 

  22. Mathews F, Youngman L, Neil A. Maternal circulating nutrient concentrations in pregnancy: implications for birth and placental weights of term infants. Am J Clin Nutr. 2004;79:103–10.

    PubMed  CAS  Google Scholar 

  23. Azar M, Basu A, Jenkins AJ, et al. Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study. Diabetes Care. 2011;34:1258–64.

    Article  PubMed  CAS  Google Scholar 

  24. Palan PR, Mikhail MS, Romney SL. Placental and serum levels of carotenoids in preeclampsia. Obstet Gynecol. 2001;98:459–62.

    Article  PubMed  CAS  Google Scholar 

  25. Banerjee S, Jeyaseelan S, Guleria R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J Obstet Gynaecol Res. 2009;35:477–82.

    Article  PubMed  CAS  Google Scholar 

  26. Sharma JB, Kumar A, Kumar A, et al. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol Obstet. 2003;81:257–62.

    Article  PubMed  CAS  Google Scholar 

  27. Miyake Y, Sasaki S, Tanaka K, Hirota Y. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy. 2010;65:758–65.

    Article  PubMed  CAS  Google Scholar 

  28. Orhon FS, Ulukol B, Kahya D, Cengiz B, Başkan S, Tezcan S. The influence of maternal smoking on maternal and newborn oxidant and antioxidant status. Eur J Pediatr. 2009;168:975–81.

    Article  PubMed  CAS  Google Scholar 

  29. Litonjua AA, Rifas-Shiman SL, Ly NP, et al. Maternal antioxidant intake in pregnancy and wheezing illness in children at 2 y of age. Am J Clin Nutr. 2006;84:903–11.

    PubMed  CAS  Google Scholar 

  30. Sausenthaler S, Koletzko S, Schaaf B, et al. Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am J Clin Nutr. 2007;85:530–7.

    PubMed  CAS  Google Scholar 

  31. Willers SM, Wijga AH, Brunekreef B, et al. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am J Respir Crit Care Med. 2008;178:124–31.

    Article  PubMed  Google Scholar 

  32. Khachik F, Spangler CJ, Smith Jr JC, Canfield LM, Steck A, Pfander H. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal Chem. 1997;69:1873–81.

    Article  PubMed  CAS  Google Scholar 

  33. Sommerburg O, Meissner K, Nelle M, Lenhartz H, Leichsenring M. Carotenoid supply in breast-fed and formula-fed neonates. Eur J Pediatr. 2000;159:86–90.

    Article  PubMed  CAS  Google Scholar 

  34. Macias C, Schweigert FJ. Changes in the concentration of carotenoids, vitamin A, alpha-tocopherol and total lipids in human milk throughout early lactation. Ann Nutr Metab. 2001;45:82–5.

    Article  PubMed  CAS  Google Scholar 

  35. Patton S, Canfield LM, Huston GE, Ferris AM, Jensen RG. Carotenoids of human colostrum. Lipds. 1990;25:159–65.

    Article  CAS  Google Scholar 

  36. Lietz G, Mulokozi G, Henry JC, Tomkins AM. Xanthophyll and hydrocarbon carotenoid patterns differ in plasma and breast milk of women supplemented with red palm oil during pregnancy and lactation. J Nutr. 2006;136:1821–7.

    PubMed  CAS  Google Scholar 

  37. Schweigert FJ, Bathe K, Chen F, Büscher U, Dudenhausen JW. Effect of the stage of lactation in humans on carotenoid levels in milk, blood plasma and plasma lipoprotein fractions. Eur J Nutr. 2004;43:39–44.

    Article  PubMed  CAS  Google Scholar 

  38. Gossage C, Deyhim M, Moser-Veillon PB, Douglas LW, Kramer TR. Effect of beta-carotene supplementation and lactation on carotenoid metabolism and mitogenic T lymphocyte proliferation. Am J Clin Nutr. 2000;71:950–5.

    PubMed  CAS  Google Scholar 

  39. Rühl R. Effects of dietary retinoids and carotenoids on immune development. Proc Nutr Soc. 2007;66:458–69.

    Article  PubMed  Google Scholar 

  40. Canfield LM, Giuliano AR, Neilson EM, et al. beta-Carotene in breast milk and serum is increased after a single beta-carotene dose. Am J Clin Nutr. 1997;66:52–61.

    PubMed  CAS  Google Scholar 

  41. Canfield LM, Giuliano AR, Neilson EM, Blashil BM, Graver EJ, Yap HH. Kinetics of the response of milk and serum beta-carotene to daily beta-carotene supplementation in healthy, lactating women. Am J Clin Nutr. 1998;67:276–83.

    PubMed  CAS  Google Scholar 

  42. Canfield LM, Taren DL, Kaminsky RG, Mahal Z. Short-term beta-carotene supplementation of lactating mothers consuming diets low in vitamin A. J Nutr Biochem. 1999;10:532–8.

    Article  PubMed  CAS  Google Scholar 

  43. Cena H, Castellazzi AM, Pietri A, Roggi C, Turconi G. Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake. Public Health Nutr. 2009;12:1878–84.

    Article  PubMed  Google Scholar 

  44. Allen CM, Smith AM, Clinton SK, Schwartz SJ. Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. J Am Diet Assoc. 2002;102:1257–62.

    Article  Google Scholar 

  45. de Azeredo VB, Trugo NM. Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. Nutrition. 2008;24:133–9.

    Article  PubMed  Google Scholar 

  46. Bates CJ, Prentice AM, Paul AA. Seasonal variations in vitamins A, C, riboflavin and folate intakes and status of pregnant and lactating women in a rural Gambian community: some possible implications. Eur J Clin Nutr. 1994;48:660–8.

    PubMed  CAS  Google Scholar 

  47. Canfield LM, Clandinin MT, Davies DP, et al. Multinational study of major breast milk carotenoids of healthy mothers. Eur J Nutr. 2003;42:133–41.

    PubMed  CAS  Google Scholar 

  48. Stoltzfus RJ, Underwood BA. Breast-milk vitamin A as an indicator of the vitamin A status of women and infants. Bull World Health Organ. 1995;73:703–11.

    PubMed  CAS  Google Scholar 

  49. de Pee S, Bloem MW, Gorstein J, et al. Reappraisal of the role of vegetables in the vitamin A status of mothers in Central Java, Indonesia. Am J Clin Nutr. 1998;68:1068–74.

    PubMed  Google Scholar 

  50. da Silva Ribeiro KD, de Araújo KF, de Souza HH, Soares FB, da Costa Pereira M, Dimenstein R. Nutritional vitamin A status in northeast Brazilian lactating mothers. J Hum Nutr Diet. 2010;23:154–61.

    Article  PubMed  Google Scholar 

  51. Lietz G, Henry CJ, Mulokozi G, et al. Comparison of the effects of supplemental red palm oil and sunflower oil on maternal vitamin A status. Am J Clin Nutr. 2001;74:501–9.

    PubMed  CAS  Google Scholar 

  52. Canfield LM, Kaminsky RG, Taren DL, Shaw E, Sander JK. Red palm oil in the maternal diet increases provitamin A carotenoids in breastmilk and serum of the mother-infant dyad. Eur J Nutr. 2001;40:30–8.

    Article  PubMed  CAS  Google Scholar 

  53. de Pee S, West CE, Muhilal, Karyadi D, Hautvast JG. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet. 1995;346:75–81

    Google Scholar 

  54. Ncube TN, Greiner T, Malaba LC, Gebre-Medhin M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr. 2001;131:1497–502.

    PubMed  CAS  Google Scholar 

  55. Khan NC, West CE, de Pee S, et al. The contribution of plant foods to the vitamin A supply of lactating women in Vietnam: A randomized controlled trial. Am J Clin Nutr. 2007;85:1112–20.

    PubMed  CAS  Google Scholar 

  56. Wasantwisut E, Sungpuag P, Viriyapanich T, et al. Effects of dietary and supplemental β-carotene interventions on total body retinol stores in lactating Thai women. FASEB J. 2000;14:371–3.

    Google Scholar 

  57. Rice AL, Stoltzfus RJ, de Francisco A, Chakraborty J, Kjolhede CL, Wahed MA. Maternal vitamin A or beta-carotene supplementation in lactating Bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency. J Nutr. 1999;129:356–65.

    PubMed  CAS  Google Scholar 

  58. Sommer A, Davidson FR. Assessment and control of vitamin A deficiency: the Annecy Accords. J Nutr. 2002;132:2845S–50S.

    PubMed  CAS  Google Scholar 

  59. Jewell VC, Mayes CB, Tubman TR, Northrop-Clewes CA, Thurnham DI. A comparison of lutein and zeaxanthin concentrations in formula and human milk samples from Northern Ireland mothers. Eur J Clin Nutr. 2004;58:90–7.

    Article  PubMed  CAS  Google Scholar 

  60. Bettler J, Zimmer JP, Neuringer M, DeRusso PA. Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein. Eur J Nutr. 2010;49:45–51.

    Article  PubMed  CAS  Google Scholar 

  61. Zimmer JP, Hammond Jr BR. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophthalmol. 2007;1:25–35.

    PubMed  CAS  Google Scholar 

  62. Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004;134:257S–61S.

    PubMed  CAS  Google Scholar 

  63. Spears JW, Weiss WP. Role of antioxidants and trace elements in health and immunity of transition dairy cows. Vet J. 2008;176:70–6.

    Article  PubMed  CAS  Google Scholar 

  64. Nishiyama Y, Sugimoto M, Ikeda S, Kume S. Supplemental β-carotene increases IgA-secreting cells in mammary gland and IgA transfer from milk to neonatal mice. Br J Nutr. 2011;105:24–30.

    Article  PubMed  CAS  Google Scholar 

  65. Adkins B, Contractor N. Immune responses of female BALB/c and C57BL/6 neonatal mice to vaccination or intestinal infection are unaltered by exposure to breast milk lycopene. J Nutr. 2011;14:1326–30.

    Google Scholar 

  66. Kato I, Ren J, Visscher DW, Djuric Z. Nutritional predictors for cellular nipple aspirate fluid: Nutrition and Breast Health Study. Breast Cancer Res Treat. 2006;97:33–9.

    Article  PubMed  Google Scholar 

  67. Djuric Z, Chen G, Ren J, et al. Effects of high fruit-vegetable and/or low-fat intervention on breast nipple aspirate fluid micronutrient levels. Cancer Epidemiol Biomarkers. 2007;16:1393–9.

    Article  CAS  Google Scholar 

  68. Nantais-Smith LM, Covington CY, Nordstrom-Klee BA, et al. Differences in plasma and nipple aspirate carotenoid by lactation status. Nurs Res. 2001;50:172–7.

    Article  PubMed  CAS  Google Scholar 

  69. Katz J, Khatry SK, West Jr KP, et al. Night blindness is prevalent during pregnancy and lactation in rural Nepal. J Nutr. 1995;125:2122–7.

    PubMed  CAS  Google Scholar 

  70. Christian P, West Jr KP, Katz J, Kimbrough-Pradhan E, LeClerq SC, Khatry SK. Cigarette smoking during pregnancy in rural Nepal. Risk factors and effects of β-carotene and vitamin A supplementation. Eur J Clin Nutr. 2004;58:204–11.

    Article  PubMed  CAS  Google Scholar 

  71. Dreyfuss ML, West KP Jr, Katz J, LeClerq SC, Pradhan EK, Adhikari RK et al. Effects of maternal vitamin A or β-carotene supplementation on intrauterine/neonatal and early infant growth in Nepal (abstract). In: Report of the XVIII International Vitamin A Consultative Group Meeting. Cairo, Egypt, ILSI Research Foundation, Washington DC 1997.

    Google Scholar 

  72. Wieringa FT, Dijkhuizen MA, Muhilal, Van der Meer JW. Maternal micronutrient supplementation with zinc and β-carotene affects morbidity and immune function of infants during the first 6 months of life. Eur J Clin Nutr. 2010;64:1072–9

    Google Scholar 

  73. Christian P, West Jr KP, Khatry SK, Katz J, Dali SM, LeClerq SC, Kimbrough-Pradhan E, Shrestha SR. The effect of vitamin A and β-carotene supplementation on self-reported illness in pregnant and lactating Nepali women. J Nutr. 2000;130:2675–82.

    PubMed  CAS  Google Scholar 

  74. Checkley W, West Jr KP, Wise RA, Baldwin MR, Wu L, LeClerq SC, Christian P, Katz J, Tielsch JM, Khatry SK, Sommer A. Maternal vitamin A supplementation and lung function in offspring. N Engl J Med. 2010;362:1784–94.

    Article  PubMed  CAS  Google Scholar 

  75. Checkley W, West Jr KP, Wise RA, Baldwin MR, Wu L, LeClerq SC, Khatry SK, Katz J, Christian P, Tielsch JM, Sommer A. Supplementation with vitamin A early in life and subsequent risk of asthma. Eur Respir J. 2011;38(6):1310–9. 23 Jun 2011 (epub).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Parul Christian Dr.P.H., Msc. .

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Schulze, K., Christian, P. (2013). Carotenoid Metabolism and Health in Pregnancy and Lactation. In: Tanumihardjo, S. (eds) Carotenoids and Human Health. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-203-2_9

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  • DOI: https://doi.org/10.1007/978-1-62703-203-2_9

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