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Provitamin A Carotenoids as a Dietary Source of Vitamin A

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Part of the book series: Nutrition and Health ((NH))

Abstract

Vitamin A deficiency (VAD) is an important public health problem that affects low-income populations in developing countries throughout the world.

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References

  1. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995–2005. WHO Global database on vitamin A deficiency. Geneva, Switzerland: WHO; 2009.

    Google Scholar 

  2. World Health Organization. Vitamin A supplements: a guide to their use in the treatment and prevention of vitamin A deficiency and xerophthalmia. Geneva, Switzerland: WHO; 1997. p. 9–18.

    Google Scholar 

  3. Sivakumar B, Reddy V. Absorption of labelled vitamin A in children during infection. Br J Nutr. 1972;27:299–304.

    Article  PubMed  CAS  Google Scholar 

  4. Alvarez JO, Salazar-Lindo E, Kohatsu J, et al. Urinary excretion of retinol in children with acute diarrhea. Am J Clin Nutr. 1995;61:1273–6.

    PubMed  CAS  Google Scholar 

  5. Stephensen CB, Alvarez JO, Kohatsu J, et al. Vitamin A is excreted in the urine during acute infection. Am J Clin Nutr. 1994;60:388–92.

    PubMed  CAS  Google Scholar 

  6. Beaton GH, Martorell R, L’Abbe KA, et al. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Nutrition Policy Discussion Paper No.13 ACC/SCN. 1993.

    Google Scholar 

  7. Christian P, West KP Jr, Khatry S, et al. Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and β-carotene supplementation. Am J Epidemiol. 2000;152:542–7.

    Article  PubMed  CAS  Google Scholar 

  8. Glasziou P, Mackerras D. Vitamin A supplementation in infectious diseases: a meta-analysis. Br Med J. 1993;306:366–70.

    Article  CAS  Google Scholar 

  9. West KP Jr, Katz J, Khatry S, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or β-carotene on mortality related to pregnancy in Nepal. BMJ. 1999;318:570–5.

    Article  PubMed  CAS  Google Scholar 

  10. Kirkwood B, Hurt L, Amenga-Etego S, et al. Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial. Lancet. 2010;375:1640–9.

    Article  PubMed  CAS  Google Scholar 

  11. West KP Jr, Christian P, Katz J, et al. Effect of vitamin A supplementation on maternal survival. Lancet. 2010;376:873–4.

    Article  PubMed  Google Scholar 

  12. Grune T, Lietz G, Palou A, et al. β-carotene is an important vitamin A source for humans. J Nutr. 2010;140:2268S–85.

    Article  PubMed  CAS  Google Scholar 

  13. Institute of Medicine. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, DC: National Academy Press; 2001.

    Google Scholar 

  14. Burri B, Chang J, Neidlinger T. β-Cryptoxanthin and α-carotene rich foods have greater apparent bioavailability than β-carotene rich foods in Western diets. Br J Nutr. 2011;105:212–9.

    Article  PubMed  CAS  Google Scholar 

  15. Tanumihardjo S, Howe J. Twice the amount of alpha-carotene isolated from carrots is as effective as beta-carotene in maintaining the vitamin A status of Mongolian gerbils. J Nutr. 2005;135:2622–6.

    PubMed  CAS  Google Scholar 

  16. Davis D, Jing H, Howe J, et al. Beta-cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils (Meriones unguiculatus) better than or equal to beta-carotene supplements. Br J Nutr. 2008;3:1–8.

    Google Scholar 

  17. Food and Agricultural Organization. Vitamin and mineral requirements in human nutrition. Report of joint FAO/WHO expert consultation. FAO, Rome: Bangkok, Thailand; 2004.

    Google Scholar 

  18. Novotny J, Harrison D, Pawlosky R, et al. β-Carotene conversion to vitamin A decreases as the dietary dose increases in humans. J Nutr. 2010;140:915–8.

    Article  PubMed  CAS  Google Scholar 

  19. Lietz G, Lange J, Rimbach G. Molecular and dietary regulation of β, β-carotene 15,15′-monooxygenase 1 (BCMO1). Arch Biochem Biophys. 2010;502:8–16.

    Article  PubMed  CAS  Google Scholar 

  20. Feskanich D, Singh V, Willett WC, et al. Vitamin A intake and hip fractures among postmenopausal women. JAMA. 2002;287:47–54.

    Article  PubMed  CAS  Google Scholar 

  21. Gaziano J, Hennekens C. The role of beta-carotene in the prevention of cardiovascular disease. Ann N Y Acad Sci. 1993;691:148–55.

    Article  PubMed  CAS  Google Scholar 

  22. The Alpha-Tocopherol β-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029–35.

    Article  Google Scholar 

  23. Omenn G, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J Natl Cancer Inst. 1996;88:1550–9.

    Article  PubMed  CAS  Google Scholar 

  24. Vijayalakshmi A. Carotenodermia. Indian Pediatr. 2008;45:61.

    PubMed  CAS  Google Scholar 

  25. West C, Eilander A, van Lieshout M. Consequences of revised estimates of carotenoid bioefficacy for dietary control of vitamin A deficiency in developing countries. J Nutr. 2002;132:2920S–6.

    PubMed  CAS  Google Scholar 

  26. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2007–2008; 2008.

    Google Scholar 

  27. Torheim L, Ferguson E, Penrose K, et al. Women in resource-poor settings are at risk of inadequate intakes of multiple micronutrients. J Nutr. 2010;140:2051S–8.

    Article  PubMed  CAS  Google Scholar 

  28. Becquey E, Martin-Prevel Y. Micronutrient adequacy of women’s diet in urban Burkina Faso is low. J Nutr. 2010;140:2079S–85.

    Article  PubMed  CAS  Google Scholar 

  29. Kennedy G, Fanou-Fogny N, Seghieri C, et al. Food groups associated with a composite measure of probability of adequate intake of 11 micronutrients in the diets of women in urban Mali. J Nutr. 2010;140:2070S–80.

    Article  PubMed  CAS  Google Scholar 

  30. Gegios A, Amthor R, Maziya-Dixon B, et al. Children consuming cassava as a staple food are at risk for inadequate zinc, iron, and vitamin A intake. Plant Foods Hum Nutr. 2010;65:64–70.

    Article  PubMed  CAS  Google Scholar 

  31. Semba R, de Pee S, Sun K, et al. Low intake of vitamin A-rich foods among children, aged 12–35 months, in India: association with malnutrition, anemia, and missed child survival interventions. Nutr J. 2010;26:958–62.

    Article  Google Scholar 

  32. de Pee S, West CE, Muhilal, et al. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet. 1995;346:75–81.

    Article  PubMed  Google Scholar 

  33. Khan N, West CE, de Pee S, et al. The contribution of plant foods to the vitamin A supply of lactating women in Vietnam: a randomized controlled trial. Am J Clin Nutr. 2007;85:1112–20.

    PubMed  CAS  Google Scholar 

  34. Ncube T, Greiner T, Malaba L, et al. Supplementing lactating women with pureed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr. 2001;131:1497–502.

    PubMed  CAS  Google Scholar 

  35. Haskell M, Pandey P, Graham J, et al. Recovery from impaired dark adaptation does not differ among nightblind pregnant Nepali women who receive small daily doses of vitamin A as either liver, vitamin A-fortified Ultra-riceTM, green leafy vegetables, carrots, or vitamin A capsules. Am J Clin Nutr. 2005;81:461–71.

    PubMed  CAS  Google Scholar 

  36. Drammeh B, Marquis G, Funkhouser E, et al. A randomized, 4-month mango and fat supplementation trial improved vitamin A status among young Gambian children. J Nutr. 2002;132:3693–9.

    PubMed  CAS  Google Scholar 

  37. Low J, Arimond M, Osman N, et al. A food-based approach introducing orange-fleshed sweet potatoes increased vitamin A intake and serum retinol concentrations in young children in rural Mozambique. J Nutr. 2007;137:1320–7.

    PubMed  CAS  Google Scholar 

  38. Tang G, Gu X, Hu S, et al. Green and yellow vegetables can maintain vitamin A body stores in Chinese children. Am J Clin Nutr. 1999;70:1069–76.

    PubMed  CAS  Google Scholar 

  39. van Jaarsveld P, Faber M, Tanumihardjo S, Nestel P, Lombard C, Spinnler Benadé A. β-Carotene-rich orange-fleshed sweet potato improves the vitamin A status of primary school children assessed with the modified-relative-dose-response test. Am J Clin Nutr. 2005;81:1080–7.

    PubMed  Google Scholar 

  40. de Pee S, West C, Permaesih D, et al. Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia. Am J Clin Nutr. 1998;68:1058–67.

    PubMed  Google Scholar 

  41. Tanumihardjo SA. Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr. 2011;94:658S–65.

    Article  PubMed  Google Scholar 

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Correspondence to Marjorie J. Haskell B.S., M.P.H., Ph.D. .

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Haskell, M.J. (2013). Provitamin A Carotenoids as a Dietary Source of Vitamin A. In: Tanumihardjo, S. (eds) Carotenoids and Human Health. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-203-2_15

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  • DOI: https://doi.org/10.1007/978-1-62703-203-2_15

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-202-5

  • Online ISBN: 978-1-62703-203-2

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