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Lycopene and Cancer

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Carotenoids and Human Health

Part of the book series: Nutrition and Health ((NH))

Abstract

Epidemiological and human clinical trials suggest that dietary intake of tomatoes or lycopene protects against cancers of the prostate, breast, cervix, ovary, endometrium, lung, bladder, oral cavity, esophagus, stomach, colon, and pancreas.

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References

  1. Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys. 2004;430(1):127–34.

    Article  PubMed  CAS  Google Scholar 

  2. Hadley CW, Miller EC, Schwartz SJ, Clinton SK. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med. 2002;227(10):869–80.

    CAS  Google Scholar 

  3. Erdman Jr JW. How do nutritional and hormonal status modify the bioavailability, uptake, and distribution of different isomers of lycopene? J Nutr. 2005;135(8):2046S–7.

    PubMed  CAS  Google Scholar 

  4. Rubio-Diaz DE, Santos A, Francis DM, Rodriguez-Saona LE. Carotenoid stability during production and storage of tomato juice made from tomatoes with diverse pigment profiles measured by infrared spectroscopy. J Agric Food Chem. 2010;58(15):8692–8.

    Article  PubMed  CAS  Google Scholar 

  5. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys. 1989;274(2):532–8.

    Article  PubMed  Google Scholar 

  6. Erdman Jr JW, Ford NA, Lindshield BL. Are the health attributes of lycopene related to its antioxidant function? Arch Biochem Biophys. 2009;483(2):229–35.

    Article  PubMed  CAS  Google Scholar 

  7. Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman Jr. JW. Lycopene and apo-12′-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells. Nutr Cancer. 2011;63(2):256–63.

    Article  PubMed  CAS  Google Scholar 

  8. Siler U, Barella L, Spitzer V, et al. Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J. 2004;18(9):1019–21.

    PubMed  CAS  Google Scholar 

  9. Liu C, Lian F, Smith DE, Russell RM, Wang XD. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res. 2003;63(12):3138–44.

    PubMed  CAS  Google Scholar 

  10. Walfisch S, Walfisch Y, Kirilov E, et al. Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev. 2007;16(4):298–303.

    Article  PubMed  CAS  Google Scholar 

  11. Riso P, Brusamolino A, Martinetti A, Porrini M. Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects. Nutr Cancer. 2006;55(2):157–62.

    Article  PubMed  CAS  Google Scholar 

  12. Herzog A, Siler U, Spitzer V, et al. Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J. 2005;19(2):272–4.

    PubMed  CAS  Google Scholar 

  13. Voskuil DW, Vrieling A, Korse CM, et al. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Nutr Cancer. 2008;60(3):342–53.

    Article  PubMed  CAS  Google Scholar 

  14. Hursting SD, Berger NA. Energy balance, host-related factors, and cancer progression. J Clin Oncol. 2010;28(26):4058–65.

    Article  PubMed  Google Scholar 

  15. Yamaguchi M, Hasegawa I, Yahagi N, Ishigaki Y, Takano F, Ohta T. Carotenoids modulate cytokine production in Peyer’s patch cells ex vivo. J Agric Food Chem. 2010;58(15):8566–72.

    Article  PubMed  CAS  Google Scholar 

  16. Palozza P, Simone R, Catalano A, et al. Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression. J Nutr Biochem. 2011;22(3):259–68.

    Article  PubMed  CAS  Google Scholar 

  17. Feng D, Ling WH, Duan RD. Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages. Inflamm Res. 2010;59(2):115–21.

    Article  PubMed  CAS  Google Scholar 

  18. Saedisomeolia A, Wood LG, Garg ML, Gibson PG, Wark PA. Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide. J Nutr Biochem. 2009;20(8):577–85.

    Article  PubMed  CAS  Google Scholar 

  19. Markovits N, Ben Amotz A, Levy Y. The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity. Isr Med Assoc J. 2009;11(10):598–601.

    PubMed  Google Scholar 

  20. Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman Jr JW. Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr. 2006;136(11):2813–9.

    PubMed  CAS  Google Scholar 

  21. Cui Y, Shikany JM, Liu S, Shagufta Y, Rohan TE. Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2008;87(4):1009–18.

    PubMed  CAS  Google Scholar 

  22. Murtaugh MA, Ma KN, Benson J, Curtin K, Caan B, Slattery ML. Antioxidants, carotenoids, and risk of rectal cancer. Am J Epidemiol. 2004;159(1):32–41.

    Article  PubMed  Google Scholar 

  23. Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1485–94.

    PubMed  CAS  Google Scholar 

  24. AICR. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington DC: AICR; 2007.

    Google Scholar 

  25. Krutovskikh V, Asamoto M, Takasuka N, Murakoshi M, Nishino H, Tsuda H. Differential dose-dependent effects of alpha-, beta-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo. Jpn J Cancer Res. 1997;88(12):1121–4.

    Article  PubMed  CAS  Google Scholar 

  26. Kucuk O, Sarkar FH, Djuric Z, et al. Effects of lycopene supplementation in patients with localized prostate cancer. Exp Biol Med. 2002;227(10):881–5.

    CAS  Google Scholar 

  27. Cheng HC, Chien H, Liao CH, Yang YY, Huang SY. Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models. J Nutr Biochem. 2007;18(10):667–75.

    Article  PubMed  CAS  Google Scholar 

  28. Tang L, Jin T, Zeng X, Wang JS. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J Nutr. 2005;135(2):287–90.

    PubMed  CAS  Google Scholar 

  29. Kim HS, Bowen P, Chen L, et al. Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. Nutr Cancer. 2003;47(1):40–7.

    Article  PubMed  CAS  Google Scholar 

  30. Bowen P, Chen L, Stacewicz-Sapuntzakis M, et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med. 2002;227(10):886–93.

    CAS  Google Scholar 

  31. Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman Jr JW. Combinations of tomato and broccoli enhance antitumor activity in Dunning R3327-H prostate adenocarcinomas. Cancer Res. 2007;67(2):836–43.

    Article  PubMed  CAS  Google Scholar 

  32. Liu C, Russell RM, Wang XD. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets. J Nutr. 2006;136(1):106–11.

    PubMed  CAS  Google Scholar 

  33. Sengupta A, Ghosh S, Das S. Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats. Eur J Cancer Prev. 2003;12(3):195–200.

    Article  PubMed  CAS  Google Scholar 

  34. Dias MC, Vieiralves NF, Gomes MI, Salvadori DM, Rodrigues MA, Barbisan LF. Effects of lycopene, synbiotic and their association on early biomarkers of rat colon carcinogenesis. Food Chem Toxicol. 2010;48(3):772–80.

    Article  PubMed  CAS  Google Scholar 

  35. Velmurugan B, Mani A, Nagini S. Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. Eur J Cancer Prev. 2005;14(4):387–93.

    Article  PubMed  CAS  Google Scholar 

  36. Kurcer MA, Kurcer Z, Koksal M, et al. Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. J Med Food. 2010;13(4):985–91.

    Article  PubMed  CAS  Google Scholar 

  37. Huang CS, Liao JW, Hu ML. Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J Nutr. 2008;138(3):538–43.

    PubMed  Google Scholar 

  38. Yang CM, Yen YT, Huang CS, Hu ML. Growth inhibitory efficacy of lycopene and beta-carotene against androgen-independent prostate tumor cells xenografted in nude mice. Mol Nutr Food Res. 2010;55(4):606–12.

    Article  PubMed  CAS  Google Scholar 

  39. Moselhy SS, Al mslmani MA. Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in Sprague Dawley female rats. Mol Cell Biochem. 2008;319(1–2):175–80.

    Article  PubMed  CAS  Google Scholar 

  40. Kasagi S, Seyama K, Mori H, et al. Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke. Am J Physiol Lung Cell Mol Physiol. 2006;290(2):L396–404.

    Article  PubMed  CAS  Google Scholar 

  41. Hwang ES, Lee HJ. Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK-Hep1 human hepatoma cells. Exp Biol Med (Maywood). 2006;231(3):322–7.

    CAS  Google Scholar 

  42. Chiang HS, Wu WB, Fang JY, et al. Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB. Life Sci. 2007;81(21–22):1509–17.

    Article  PubMed  CAS  Google Scholar 

  43. Wu WB, Chiang HS, Fang JY, Hung CF. Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer. Biochem Soc Trans. 2007;35(Pt 5):1377–8.

    PubMed  CAS  Google Scholar 

  44. Huang CS, Shih MK, Chuang CH, Hu ML. Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J Nutr. 2005;135(9):2119–23.

    PubMed  CAS  Google Scholar 

  45. National Cancer Institute. 2011. http://www.cancer.gov/cancertopics/types. http://www.cancer.gov/cancertopics/types/prostate. Accessed 14 Mar.

  46. Djavan B. The correlation between inflammation, BPH, and prostate cancer. Eur Urol Suppl. 2009;8(13):863–4.

    Article  Google Scholar 

  47. Kucuk O, Sarkar FH, Sakr W, et al. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 2001;10(8):861–8.

    PubMed  CAS  Google Scholar 

  48. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst. 1995;87(23):1767–76.

    Article  PubMed  CAS  Google Scholar 

  49. Etminan M, Takkouche B, Caamano-Isorna F. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. 2004;13(3):340–5.

    PubMed  CAS  Google Scholar 

  50. Simon MS, Djuric Z, Dunn B, Stephens D, Lababidi S, Heilbrun LK. An evaluation of plasma antioxidant levels and the risk of breast cancer: a pilot case control study. Breast J. 2000;6(6):388–95.

    Article  PubMed  Google Scholar 

  51. Rieck G, Fiander A. The effect of lifestyle factors on gynaecological cancer. Best Pract Res Clin Obstet Gynaecol. 2006;20(2):227–51.

    Article  PubMed  Google Scholar 

  52. Jeong NH, Song ES, Lee JM, et al. Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer. Acta Obstet Gynecol Scand. 2009;88(4):457–62.

    Article  PubMed  CAS  Google Scholar 

  53. Cramer DW, Kuper H, Harlow BL, Titus-Ernstoff L. Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women. Int J Cancer. 2001;94(1):128–34.

    Article  PubMed  CAS  Google Scholar 

  54. McCann SE, Freudenheim JL, Marshall JR, Brasure JR, Swanson MK, Graham S. Diet in the epidemiology of endometrial cancer in western New York (United States). Cancer Causes Control. 2000;11(10):965–74.

    Article  PubMed  CAS  Google Scholar 

  55. Horner MJ, Ries LAG, Krapcho M, et al. SEER cancer statistics review, 1975–2006. Bethesda, MD: National Cancer Institute; 2009. http://seer.cancer.gov/csr/1975_2006/, based on November 2008 SEER data submission, posted to the SEER web site.

    Google Scholar 

  56. Goodman GE, Thornquist MD, Balmes J, et al. The beta-carotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst. 2004;96(23):1743–50.

    Article  PubMed  CAS  Google Scholar 

  57. Smith-Warner SA, Spiegelman D, Yaun SS, et al. Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. Int J Cancer. 2003;107(6):1001–11.

    Article  PubMed  CAS  Google Scholar 

  58. Mannisto S, Smith-Warner SA, Spiegelman D, et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev. 2004;13(1):40–8.

    Article  PubMed  Google Scholar 

  59. Preedy VR, Watson RR, editors. Lycopene: nutritional medicinal and therapeutic properties. Enfield, NH: Science Publishers; 2008.

    Google Scholar 

  60. Busby JE, Kamat AM. Chemoprevention for bladder cancer. J Urol. 2006;176(5):1914–20.

    Article  PubMed  CAS  Google Scholar 

  61. Castelao JE, Yuan JM, Gago-Dominguez M, et al. Carotenoids/vitamin C and smoking-related bladder cancer. Int J Cancer. 2004;110(3):417–23.

    Article  PubMed  CAS  Google Scholar 

  62. Sasaki T, Horikawa M, Orikasa K, et al. Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype. Jpn J Clin Oncol. 2008;38(9):634–40.

    Article  PubMed  Google Scholar 

  63. Lambert R, Hainaut P. The multidisciplinary management of gastrointestinal cancer. Epidemiology of oesophagogastric cancer. Best Pract Res Clin Gastroenterol. 2007;21(6):921–45.

    Article  PubMed  CAS  Google Scholar 

  64. Ramon JM, Serra L, Cerdo C, Oromi J. Dietary factors and gastric cancer risk. A case-control study in Spain. Cancer. 1993;71(5):1731–5.

    Article  PubMed  CAS  Google Scholar 

  65. Buiatti E, Palli D, Decarli A, et al. A case-control study of gastric cancer and diet in Italy: II. Association with nutrients. Int J Cancer. 1990;45(5):896–901.

    Article  PubMed  CAS  Google Scholar 

  66. Tammariello AE, Milner JA. Mouse models for unraveling the importance of diet in colon cancer prevention. J Nutr Biochem. 2010;21(2):77–88.

    Article  PubMed  CAS  Google Scholar 

  67. Hu JF, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ. Diet and cancer of the colon and rectum: a case-control study in China. Int J Epidemiol. 1991;20(2):362–7.

    Article  PubMed  CAS  Google Scholar 

  68. Burgess LC, Rice E, Fischer T, et al. Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range. Toxicol In Vitro. 2008;22(5):1297–300.

    Article  PubMed  CAS  Google Scholar 

  69. Hantz HL, Young LF, Martin KR. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Exp Biol Med. 2005;230(3):171–9.

    CAS  Google Scholar 

  70. Canene-Adams K, Campbell JK, Zaripheh S, Jeffery EH, Erdman Jr JW. The tomato as a functional food. J Nutr. 2005;135(5):1226–30.

    PubMed  CAS  Google Scholar 

  71. Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman Jr JW, Clinton SK. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst. 2003;95(21):1578–86.

    Article  PubMed  CAS  Google Scholar 

  72. Balestrieri ML, De Prisco R, Nicolaus B, et al. Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. Free Radic Biol Med. 2004;36(8):1058–67.

    Article  PubMed  CAS  Google Scholar 

  73. Nara E, Hayashi H, Kotake M, Miyashita K, Nagao A. Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr Cancer. 2001;39(2):273–83.

    Article  PubMed  CAS  Google Scholar 

  74. Pastori M, Pfander H, Boscoboinik D, Azzi A. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun. 1998;250(3):582–5.

    Article  PubMed  CAS  Google Scholar 

  75. Bureyko T, Hurdle H, Metcalfe JB, Clandinin MT, Mazurak VC. Reduced growth and integrin expression of prostate cells cultured with lycopene, vitamin E and fish oil in vitro. Br J Nutr. 2009;101(7):990–7.

    Article  PubMed  CAS  Google Scholar 

  76. Richards LR, Benghuzzi H, Tucci M, Hughes J. The synergistic effect of conventional and sustained delivery of antioxidants on LNCaP prostate cancer cell line. Biomed Sci Instrum. 2003;39:402–7.

    PubMed  CAS  Google Scholar 

  77. Basu A, Imrhan V. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur J Clin Nutr. 2007;61(3):295–303.

    Article  PubMed  CAS  Google Scholar 

  78. Clinton SK. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev. 1998;56(2 Pt 1):35–51.

    PubMed  CAS  Google Scholar 

  79. Mills PK, Beeson WL, Phillips RL, Fraser GE. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer. 1989;64(3):598–604.

    Article  PubMed  CAS  Google Scholar 

  80. Giovannucci E. Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature. J Nutr. 2005;135(8):2030S–1.

    PubMed  CAS  Google Scholar 

  81. Schuman LM, Mandel JS, Radke A, Seal U, Halberg F. Some selected features of the epidemiology of prostatic cancer: Minneapolis-St. Paul, Minnesota case-control study, 1976–1979. In: Magnus K, editor. Trends in cancer incidence; causes and practical implications. Washington, DC: Hemisphere; 1982. p. 345–54.

    Google Scholar 

  82. Cerhan JR, Cantor KP, Williamson K, Lynch CF, Torner JC, Burmeister LF. Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States). Cancer Causes Control. 1998;9(3):311–9.

    Article  PubMed  CAS  Google Scholar 

  83. Salem S, Salahi M, Mohseni M, et al. Major dietary factors and prostate cancer risk: a prospective multicenter case-control study. Nutr Cancer. 2011;63(1):21–7.

    PubMed  Google Scholar 

  84. Darlington GA, Kreiger N, Lightfoot N, Purdham J, Sass-Kortsak A. Prostate cancer risk and diet, recreational physical activity and cigarette smoking. Chronic Dis Can. 2007;27(4):145–53.

    PubMed  Google Scholar 

  85. Stram DO, Hankin JH, Wilkens LR, et al. Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States). Cancer Causes Control. 2006;17(9):1193–207.

    Article  PubMed  Google Scholar 

  86. Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. Prostate cancer and dietary carotenoids. Am J Epidemiol. 2000;151(2):119–23.

    Article  PubMed  CAS  Google Scholar 

  87. Gallus S, Talamini R, Bosetti C, et al. Pizza consumption and the risk of breast, ovarian and prostate cancer. Eur J Cancer Prev. 2006;15(1):74–6.

    Article  PubMed  Google Scholar 

  88. Gann PH, Ma J, Giovannucci E, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999;59(6):1225–30.

    PubMed  CAS  Google Scholar 

  89. Jian L, Lee AH, Binns CW. Tea and lycopene protect against prostate cancer. Asia Pac J Clin Nutr. 2007;16 Suppl 1:453–7.

    PubMed  CAS  Google Scholar 

  90. Vogt TM, Mayne ST, Graubard BI, et al. Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. Am J Epidemiol. 2002;155(11):1023–32.

    Article  PubMed  CAS  Google Scholar 

  91. Heber D, Lu QY. Overview of mechanisms of action of lycopene. Exp Biol Med. 2002;227(10):920–3.

    CAS  Google Scholar 

  92. McCann SE, Ambrosone CB, Moysich KB, et al. Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York. Nutr Cancer. 2005;53(1):33–41.

    Article  PubMed  CAS  Google Scholar 

  93. Hsing AW, Comstock GW, Abbey H, Polk BF. Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. J Natl Cancer Inst. 1990;82(11):941–6.

    Article  PubMed  CAS  Google Scholar 

  94. Key TJ, Silcocks PB, Davey GK, Appleby PN, Bishop DT. A case-control study of diet and prostate cancer. Br J Cancer. 1997;76(5):678–87.

    Article  PubMed  CAS  Google Scholar 

  95. Nomura AM, Stemmermann GN, Lee J, Craft NE. Serum micronutrients and prostate cancer in Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev. 1997;6(7):487–91.

    PubMed  CAS  Google Scholar 

  96. Kirsh VA, Mayne ST, Peters U, et al. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(1):92–8.

    Article  PubMed  CAS  Google Scholar 

  97. Pourmand G, Salem S, Mehrsai A, et al. The risk factors of prostate cancer: a multicentric case-control study in Iran. Asian Pac J Cancer Prev. 2007;8(3):422–8.

    PubMed  Google Scholar 

  98. Bosetti C, Talamini R, Montella M, et al. Retinol, carotenoids and the risk of prostate cancer: a case-control study from Italy. Int J Cancer. 2004;112(4):689–92.

    Article  PubMed  CAS  Google Scholar 

  99. Wu K, Erdman Jr JW, Schwartz SJ, et al. Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2004;13(2):260–9.

    Article  PubMed  CAS  Google Scholar 

  100. Huang HY, Alberg AJ, Norkus EP, Hoffman SC, Comstock GW, Helzlsouer KJ. Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol. 2003;157(4):335–44.

    Article  PubMed  Google Scholar 

  101. Schuurman AG, Goldbohm RA, Brants HA, van den Brandt PA. A prospective cohort study on intake of retinol, vitamins C and E, and carotenoids and prostate cancer risk (Netherlands). Cancer Causes Control. 2002;13(6):573–82.

    Article  PubMed  Google Scholar 

  102. Le Marchand L, Hankin JH, Kolonel LN, Wilkens LR. Vegetable and fruit consumption in relation to prostate cancer risk in Hawaii: a reevaluation of the effect of dietary beta-carotene. Am J Epidemiol. 1991;133(3):215–9.

    PubMed  Google Scholar 

  103. Do MH, Lee SS, Kim JY, Jung PJ, Lee MH. Fruits, vegetables, soy foods and breast cancer in pre- and postmenopausal Korean women: a case-control study. Int J Vitam Nutr Res. 2007;77(2):130–41.

    PubMed  CAS  Google Scholar 

  104. Ewertz M, Gill C. Dietary factors and breast-cancer risk in Denmark. Int J Cancer. 1990;46(5):779–84.

    Article  PubMed  CAS  Google Scholar 

  105. Levi F, Pasche C, Lucchini F, La Vecchia C. Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer. 2001;91(2):260–3.

    Article  PubMed  CAS  Google Scholar 

  106. Zhang S, Tang G, Russell RM, et al. Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects. Am J Clin Nutr. 1997;66(3):626–32.

    PubMed  CAS  Google Scholar 

  107. Dorjgochoo T, Gao YT, Chow WH, et al. Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS). Breast Cancer Res Treat. 2009;117(2):381–9.

    Article  PubMed  CAS  Google Scholar 

  108. Huang JP, Zhang M, Holman CD, Xie X. Dietary carotenoids and risk of breast cancer in Chinese women. Asia Pac J Clin Nutr. 2007;16 Suppl 1:437–42.

    PubMed  Google Scholar 

  109. Tamimi RM, Colditz GA, Hankinson SE. Circulating carotenoids, mammographic density, and subsequent risk of breast cancer. Cancer Res. 2009;69(24):9323–9.

    Article  PubMed  CAS  Google Scholar 

  110. Kabat GC, Kim M, Adams-Campbell LL, et al. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. Am J Clin Nutr. 2009;90(1):162–9.

    Article  PubMed  CAS  Google Scholar 

  111. Freudenheim JL, Marshall JR, Vena JE, et al. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst. 1996;88(6):340–8.

    Article  PubMed  CAS  Google Scholar 

  112. Wang C, Baumgartner RN, Yang D, et al. No evidence of association between breast cancer risk and dietary carotenoids, retinols, vitamin C and tocopherols in Southwestern Hispanic and non-Hispanic White women. Breast Cancer Res Treat. 2009;114(1):137–45.

    Article  PubMed  CAS  Google Scholar 

  113. Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr. 2005;81(5):990–7.

    PubMed  CAS  Google Scholar 

  114. Tamimi RM, Hankinson SE, Campos H, et al. Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. Am J Epidemiol. 2005;161(2):153–60.

    Article  PubMed  Google Scholar 

  115. Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary carotenoids and risk of breast cancer. Am J Clin Nutr. 2002;76(4):883–8.

    PubMed  CAS  Google Scholar 

  116. Sato R, Helzlsouer KJ, Alberg AJ, Hoffman SC, Norkus EP, Comstock GW. Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2002;11(5):451–7.

    PubMed  CAS  Google Scholar 

  117. Hulten K, Van Kappel AL, Winkvist A, et al. Carotenoids, alpha-tocopherols, and retinol in plasma and breast cancer risk in northern Sweden. Cancer Causes Control. 2001;12(6):529–37.

    Article  PubMed  CAS  Google Scholar 

  118. La Vecchia C. Tomatoes, lycopene intake, and digestive tract and female hormone-related neoplasms. Exp Biol Med (Maywood). 2002;227(10):860–3.

    Google Scholar 

  119. Potischman N, McCulloch CE, Byers T, et al. Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A. Am J Clin Nutr. 1990;52(5):909–15.

    PubMed  CAS  Google Scholar 

  120. London SJ, Stein EA, Henderson IC, et al. Carotenoids, retinol, and vitamin E and risk of proliferative benign breast disease and breast cancer. Cancer Causes Control. 1992;3(6):503–12.

    Article  PubMed  CAS  Google Scholar 

  121. Dorgan JF, Sowell A, Swanson CA, et al. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control. 1998;9(1):89–97.

    Article  PubMed  CAS  Google Scholar 

  122. VanEenwyk J, Davis FG, Bowen PE. Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer. 1991;48(1):34–8.

    Article  PubMed  CAS  Google Scholar 

  123. Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW. Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol Biomarkers Prev. 1993;2(4):335–9.

    PubMed  CAS  Google Scholar 

  124. Potischman N, Herrero R, Brinton LA, et al. A case-control study of nutrient status and invasive cervical cancer. II. Serologic indicators. Am J Epidemiol. 1991;134(11):1347–55.

    PubMed  CAS  Google Scholar 

  125. Kanetsky PA, Gammon MD, Mandelblatt J, et al. Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women. Nutr Cancer. 1998;31(1):31–40.

    Article  PubMed  CAS  Google Scholar 

  126. Goodman MT, Kiviat N, McDuffie K, et al. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Cancer Epidemiol Biomarkers Prev. 1998;7(6):537–44.

    PubMed  CAS  Google Scholar 

  127. Nagata C, Shimizu H, Yoshikawa H, et al. Serum carotenoids and vitamins and risk of cervical dysplasia from a case-control study in Japan. Br J Cancer. 1999;81(7):1234–7.

    Article  PubMed  CAS  Google Scholar 

  128. Schiff MA, Patterson RE, Baumgartner RN, et al. Serum carotenoids and risk of cervical intraepithelial neoplasia in Southwestern American Indian women. Cancer Epidemiol Biomarkers Prev. 2001;10(11):1219–22.

    PubMed  CAS  Google Scholar 

  129. Zhang M, Holman CD, Binns CW. Intake of specific carotenoids and the risk of epithelial ovarian cancer. Br J Nutr. 2007;98(1):187–93.

    Article  PubMed  CAS  Google Scholar 

  130. Koushik A, Hunter DJ, Spiegelman D, et al. Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies. Int J Cancer. 2006;119(9):2148–54.

    Article  PubMed  CAS  Google Scholar 

  131. Helzlsouer KJ, Alberg AJ, Norkus EP, Morris JS, Hoffman SC, Comstock GW. Prospective study of serum micronutrients and ovarian cancer. J Natl Cancer Inst. 1996;88(1):32–7.

    Article  PubMed  CAS  Google Scholar 

  132. Jain MG, Rohan TE, Howe GR, Miller AB. A cohort study of nutritional factors and endometrial cancer. Eur J Epidemiol. 2000;16(10):899–905.

    Article  PubMed  CAS  Google Scholar 

  133. Pelucchi C, Dal Maso L, Montella M, et al. Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. Cancer Causes Control. 2008;19(10):1209–15.

    Article  PubMed  Google Scholar 

  134. Agudo A, Esteve MG, Pallares C, et al. Vegetable and fruit intake and the risk of lung cancer in women in Barcelona, Spain. Eur J Cancer. 1997;33(8):1256–61.

    Article  PubMed  CAS  Google Scholar 

  135. Brennan P, Butler J, Agudo A, et al. Joint effect of diet and environmental tobacco smoke on risk of lung cancer among nonsmokers. J Natl Cancer Inst. 2000;92(5):426–7.

    Article  PubMed  CAS  Google Scholar 

  136. Darby S, Whitley E, Doll R, Key T, Silcocks P. Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England. Br J Cancer. 2001;84(5):728–35.

    Article  PubMed  CAS  Google Scholar 

  137. Forman MR, Yao SX, Graubard BI, et al. The effect of dietary intake of fruits and vegetables on the odds ratio of lung cancer among Yunnan tin miners. Int J Epidemiol. 1992;21(3):437–41.

    Article  PubMed  CAS  Google Scholar 

  138. Goodman MT, Kolonel LN, Wilkens LR, Yoshizawa CN, Le Marchand L, Hankin JH. Dietary factors in lung cancer prognosis. Eur J Cancer. 1992;28(2–3):495–501.

    Article  PubMed  CAS  Google Scholar 

  139. Le Marchand L, Yoshizawa CN, Kolonel LN, Hankin JH, Goodman MT. Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. J Natl Cancer Inst. 1989;81(15):1158–64.

    Article  PubMed  Google Scholar 

  140. Ziegler RG, Mayne ST, Swanson CA. Nutrition and lung cancer. Cancer Causes Control. 1996;7(1):157–77.

    Article  PubMed  CAS  Google Scholar 

  141. Garcia-Closas R, Agudo A, Gonzalez CA, Riboli E. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Nutr Cancer. 1998;32(3):154–8.

    Article  PubMed  CAS  Google Scholar 

  142. Fraser GE, Beeson WL, Phillips RL. Diet and lung cancer in California Seventh-day Adventists. Am J Epidemiol. 1991;133(7):683–93.

    PubMed  CAS  Google Scholar 

  143. Knekt P, Jarvinen R, Teppo L, Aromaa A, Seppanen R. Role of various carotenoids in lung cancer prevention. J Natl Cancer Inst. 1999;91(2):182–4.

    Article  PubMed  CAS  Google Scholar 

  144. Mayne ST, Janerich DT, Greenwald P, et al. Dietary beta carotene and lung cancer risk in U.S. nonsmokers. J Natl Cancer Inst. 1994;86(1):33–8.

    Article  PubMed  CAS  Google Scholar 

  145. Kvale G, Bjelke E, Gart JJ. Dietary habits and lung cancer risk. Int J Cancer. 1983;31(4):397–405.

    Article  PubMed  CAS  Google Scholar 

  146. Axelsson G, Liljeqvist T, Andersson L, Bergman B, Rylander R. Dietary factors and lung cancer among men in west Sweden. Int J Epidemiol. 1996;25(1):32–9.

    Article  PubMed  CAS  Google Scholar 

  147. Bond GG, Thompson FE, Cook RR. Dietary vitamin A and lung cancer: results of a case-control study among chemical workers. Nutr Cancer. 1987;9(2–3):109–21.

    Article  PubMed  CAS  Google Scholar 

  148. De Stefani E, Brennan P, Boffetta P, et al. Diet and adenocarcinoma of the lung: a case-control study in Uruguay. Lung Cancer. 2002;35(1):43–51.

    Article  PubMed  Google Scholar 

  149. Muscat JE, Huncharek M. Dietary intake and the risk of malignant mesothelioma. Br J Cancer. 1996;73(9):1122–5.

    Article  PubMed  CAS  Google Scholar 

  150. Yuan JM, Ross RK, Chu XD, Gao YT, Yu MC. Prediagnostic levels of serum beta-cryptoxanthin and retinol predict smoking-related lung cancer risk in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2001;10(7):767–73.

    PubMed  CAS  Google Scholar 

  151. Holick CN, Michaud DS, Stolzenberg-Solomon R, et al. Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol. 2002;156(6):536–47.

    Article  PubMed  Google Scholar 

  152. Michaud DS, Feskanich D, Rimm EB, et al. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Am J Clin Nutr. 2000;72(4):990–7.

    PubMed  CAS  Google Scholar 

  153. Le Marchand L, Hankin JH, Kolonel LN, Beecher GR, Wilkens LR, Zhao LP. Intake of specific carotenoids and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 1993;2(3):183–7.

    PubMed  Google Scholar 

  154. Speizer FE, Colditz GA, Hunter DJ, Rosner B, Hennekens C. Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA). Cancer Causes Control. 1999;10(5):475–82.

    Article  PubMed  CAS  Google Scholar 

  155. Voorrips LE, Goldbohm RA, Brants HA, et al. A prospective cohort study on antioxidant and folate intake and male lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2000;9(4):357–65.

    PubMed  CAS  Google Scholar 

  156. Wright ME, Mayne ST, Swanson CA, Sinha R, Alavanja MC. Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women’s health study (United States). Cancer Causes Control. 2003;14(1):85–96.

    Article  PubMed  Google Scholar 

  157. Ito Y, Wakai K, Suzuki K, et al. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Cancer Sci. 2003;94(1):57–63.

    Article  PubMed  CAS  Google Scholar 

  158. Yuan JM, Stram DO, Arakawa K, Lee HP, Yu MC. Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):890–8.

    PubMed  CAS  Google Scholar 

  159. Rohan TE, Jain M, Howe GR, Miller AB. A cohort study of dietary carotenoids and lung cancer risk in women (Canada). Cancer Causes Control. 2002;13(3):231–7.

    Article  PubMed  Google Scholar 

  160. Steinmetz KA, Potter JD, Folsom AR. Vegetables, fruit, and lung cancer in the Iowa Women’s Health Study. Cancer Res. 1993;53(3):536–43.

    PubMed  CAS  Google Scholar 

  161. Candelora EC, Stockwell HG, Armstrong AW, Pinkham PA. Dietary intake and risk of lung cancer in women who never smoked. Nutr Cancer. 1992;17(3):263–70.

    Article  PubMed  CAS  Google Scholar 

  162. Comstock GW, Alberg AJ, Huang HY, et al. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomarkers Prev. 1997;6(11):907–16.

    PubMed  CAS  Google Scholar 

  163. Bruemmer B, White E, Vaughan TL, Cheney CL. Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol. 1996;144(5):485–95.

    Article  PubMed  CAS  Google Scholar 

  164. Helzlsouer KJ, Comstock GW, Morris JS. Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res. 1989;49(21):6144–8.

    PubMed  CAS  Google Scholar 

  165. Nomura AM, Kolonel LN, Hankin JH, Yoshizawa CN. Dietary factors in cancer of the lower urinary tract. Int J Cancer. 1991;48(2):199–205.

    Article  PubMed  CAS  Google Scholar 

  166. Hung RJ, Zhang ZF, Rao JY, et al. Protective effects of plasma carotenoids on the risk of bladder cancer. J Urol. 2006;176(3):1192–7.

    Article  PubMed  CAS  Google Scholar 

  167. Nomura AM, Lee J, Stemmermann GN, Franke AA. Serum vitamins and the subsequent risk of bladder cancer. J Urol. 2003;170(4 Pt 1):1146–50.

    Article  PubMed  CAS  Google Scholar 

  168. Michaud DS, Pietinen P, Taylor PR, Virtanen M, Virtamo J, Albanes D. Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer. 2002;87(9):960–5.

    Article  PubMed  CAS  Google Scholar 

  169. Zeegers MP, Goldbohm RA, van den Brandt PA. Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer. 2001;85(7):977–83.

    Article  PubMed  CAS  Google Scholar 

  170. Franceschi S, Bidoli E, La Vecchia C, Talamini R, D’Avanzo B, Negri E. Tomatoes and risk of digestive-tract cancers. Int J Cancer. 1994;59(2):181–4.

    Article  PubMed  CAS  Google Scholar 

  171. Zheng W, Blot WJ, Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res. 1993;53(4):795–8.

    PubMed  CAS  Google Scholar 

  172. Zheng W, Blot WJ, Shu XO, et al. Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet. Cancer Epidemiol Biomarkers Prev. 1992;1(6):441–8.

    PubMed  CAS  Google Scholar 

  173. Sapkota A, Hsu CC, Zaridze D, et al. Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe. Cancer Causes Control. 2008;19(10):1161–70.

    Article  PubMed  CAS  Google Scholar 

  174. Cook-Mozaffari PJ, Azordegan F, Day NE, Ressicaud A, Sabai C, Aramesh B. Oesophageal cancer studies in the Caspian Littoral of Iran: results of a case-control study. Br J Cancer. 1979;39(3):293–309.

    Article  PubMed  CAS  Google Scholar 

  175. Lagiou P, Talamini R, Samoli E, et al. Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study. Int J Cancer. 2009;124(11):2671–6.

    Article  PubMed  CAS  Google Scholar 

  176. Brown LM, Blot WJ, Schuman SH, et al. Environmental factors and high risk of esophageal cancer among men in coastal South Carolina. J Natl Cancer Inst. 1988;80(20):1620–5.

    Article  PubMed  CAS  Google Scholar 

  177. De Stefani E, Ronco AL, Boffetta P, et al. Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutr Cancer. 2006;56(2):149–57.

    Article  PubMed  Google Scholar 

  178. Haenszel W, Kurihara M, Segi M, Lee RK. Stomach cancer among Japanese in Hawaii. J Natl Cancer Inst. 1972;49(4):969–88.

    PubMed  CAS  Google Scholar 

  179. Modan B, Cuckle H, Lubin F. A note on the role of dietary retinol and carotene in human gastro-intestinal cancer. Int J Cancer. 1981;28(4):421–4.

    Article  PubMed  CAS  Google Scholar 

  180. Correa P, Fontham E, Pickle LW, Chen V, Lin YP, Haenszel W. Dietary determinants of gastric cancer in south Louisiana inhabitants. J Natl Cancer Inst. 1985;75(4):645–54.

    PubMed  CAS  Google Scholar 

  181. Tuyns AJ, Kaaks R, Haelterman M, Riboli E. Diet and gastric cancer. A case-control study in Belgium. Int J Cancer. 1992;51(1):1–6.

    Article  PubMed  CAS  Google Scholar 

  182. Boeing H, Jedrychowski W, Wahrendorf J, Popiela T, Tobiasz-Adamczyk B, Kulig A. Dietary risk factors in intestinal and diffuse types of stomach cancer: a multicenter case-control study in Poland. Cancer Causes Control. 1991;2(4):227–33.

    Article  PubMed  CAS  Google Scholar 

  183. Gonzalez CA, Sanz JM, Marcos G, et al. Dietary factors and stomach cancer in Spain: a multi-centre case-control study. Int J Cancer. 1991;49(4):513–9.

    Article  PubMed  CAS  Google Scholar 

  184. Tajima K, Tominaga S. Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res. 1985;76(8):705–16.

    PubMed  CAS  Google Scholar 

  185. Ekstrom AM, Serafini M, Nyren O, Hansson LE, Ye W, Wolk A. Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. Int J Cancer. 2000;87(1):133–40.

    Article  PubMed  CAS  Google Scholar 

  186. Pelucchi C, Tramacere I, Bertuccio P, Tavani A, Negri E, La Vecchia C. Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study. Ann Oncol. 2009;20(1):160–5.

    Article  PubMed  CAS  Google Scholar 

  187. De Stefani E, Boffetta P, Brennan P, et al. Dietary carotenoids and risk of gastric cancer: a case-control study in Uruguay. Eur J Cancer Prev. 2000;9(5):329–34.

    Article  PubMed  Google Scholar 

  188. Nouraie M, Pietinen P, Kamangar F, et al. Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev. 2005;14(9):2087–92.

    Article  PubMed  CAS  Google Scholar 

  189. Lissowska J, Gail MH, Pee D, et al. Diet and stomach cancer risk in Warsaw, Poland. Nutr Cancer. 2004;48(2):149–59.

    Article  PubMed  CAS  Google Scholar 

  190. Garcia-Closas R, Gonzalez CA, Agudo A, Riboli E. Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes Control. 1999;10(1):71–5.

    Article  PubMed  CAS  Google Scholar 

  191. Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC. Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2004;13(11 Pt 1):1772–80.

    PubMed  CAS  Google Scholar 

  192. Jenab M, Riboli E, Ferrari P, et al. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition. Br J Cancer. 2006;95(3):406–15.

    Article  PubMed  CAS  Google Scholar 

  193. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000;88(4):737–48.

    Article  PubMed  CAS  Google Scholar 

  194. Larsson SC, Bergkvist L, Naslund I, Rutegard J, Wolk A. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study. Am J Clin Nutr. 2007;85(2):497–503.

    PubMed  CAS  Google Scholar 

  195. Malila N, Hakulinen T. Epidemiological trends of colorectal cancer in the Nordic countries. Scand J Surg. 2003;92(1):5–9.

    PubMed  CAS  Google Scholar 

  196. Centonze S, Boeing H, Leoci C, Guerra V, Misciagna G. Dietary habits and colorectal cancer in a low-risk area. Results from a population-based case-control study in southern Italy. Nutr Cancer. 1994;21(3):233–46.

    Article  PubMed  CAS  Google Scholar 

  197. Tuyns AJ, Kaaks R, Haelterman M. Colorectal cancer and the consumption of foods: a case-control study in Belgium. Nutr Cancer. 1988;11(3):189–204.

    Article  PubMed  CAS  Google Scholar 

  198. Mannisto S, Yaun SS, Hunter DJ, et al. Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. Am J Epidemiol. 2007;165(3):246–55.

    Article  PubMed  Google Scholar 

  199. Bueno de Mesquita HB, Maisonneuve P, Runia S, Moerman CJ. Intake of foods and nutrients and cancer of the exocrine pancreas: a population-based case-control study in The Netherlands. Int J Cancer. 1991;48(4):540–9.

    Article  PubMed  CAS  Google Scholar 

  200. Nkondjock A, Ghadirian P, Johnson KC, Krewski D. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J Nutr. 2005;135(3):592–7.

    PubMed  CAS  Google Scholar 

  201. Nothlings U, Wilkens LR, Murphy SP, Hankin JH, Henderson BE, Kolonel LN. Vegetable intake and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol. 2007;165(2):138–47.

    Article  PubMed  Google Scholar 

  202. Burney PG, Comstock GW, Morris JS. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr. 1989;49(5):895–900.

    PubMed  CAS  Google Scholar 

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Ford, N., Erdman, J.W. (2013). Lycopene and Cancer. In: Tanumihardjo, S. (eds) Carotenoids and Human Health. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-203-2_12

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