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Mesenchymal Stromal Cell Therapy in Crohn’s Disease

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Mesenchymal Stem Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Mesenchymal stromal cells (MSCs) have been shown to possess the ­ability to home to injured tissues and actively participate in tissue repair. They have the ability to suppress immune responses both in vitro and in vivo and in animal models of experimental autoimmune diseases. In patients with acute and chronic immune diseases, this capacity of MSCs has also been observed. The tendency of MSCs to regenerate damaged tissue combined with their capability to regulate immune and inflammatory responses gives a strong rationale for using MSCs as a new treatment option in diseases characterized by inflammation with severe tissue damage, such as Crohn’s disease. This chapter highlights the present knowledge on MSCs in Crohn’s disease. The application of MSCs in experimental colitis models and clinical trials with MSCs in luminal and fistulizing Crohn’s disease are discussed.

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Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands

    Ilse Molendijk & Marjolijn Duijvestein

  2. Department of Gastroenterology and Hepatology, Leiden, The Netherlands

    Daan W. Hommes

  3. Division of Digestive Diseases, University of California Los Angeles, Los Angeles, USA

    Daan W. Hommes

Authors
  1. Ilse Molendijk
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  2. Daan W. Hommes
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  3. Marjolijn Duijvestein
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Corresponding author

Correspondence to Ilse Molendijk .

Editor information

Editors and Affiliations

  1. Cellular Dynamics International, Inc., Science Drive 525, Madison, 53711, Wisconsin, USA

    Lucas G. Chase

  2. , Stem Cells and Regenerative Medicine, Life Technologies, Executive Way 7335, Frederick, 21704, Maryland, USA

    Mohan C. Vemuri

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Molendijk, I., Hommes, D.W., Duijvestein, M. (2013). Mesenchymal Stromal Cell Therapy in Crohn’s Disease. In: Chase, L., Vemuri, M. (eds) Mesenchymal Stem Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-200-1_11

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