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Optimizing Ablative Therapy: Manipulating the Microenvironment

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Imaging and Focal Therapy of Early Prostate Cancer

Part of the book series: Current Clinical Urology ((CCU))

Abstract

Efforts to optimize ablative therapies rely on an understanding of the combinatorial effects of the biophysical events related to the “energy” component of the therapy and the molecular mechanisms of response that, together, impact stress levels on cancer cells and therefore efficacy. Cryoablation is long recognized for its destructive action based on biophysical parameters associated with ice intrusion on cellular and tissue structure. More recent evidence has revealed a complex set of molecular responses that provides a path for optimization using cryosensitizing agents. In this chapter, we identify those elements key to effective cryoablation and likely future approaches designed to optimize cancer cell mortality while reducing damage to nontargeted, adjacent tissues.

An erratum to this chapter is available at http:/dx.doi.org/10.1007/978-1-62703-182-0_29

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-1-62703-182-0_29

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Authors and Affiliations

  1. Institute of Biomedical Technology, State University of New York, Binghamton, NY, 13901, USA

    John M. Baust B.S., Ph.D., Kimberly Santucci B.A. & Anthony Robilotto M.S.

  2. Department of Surgery, State University of New York, Bufallo, NY, 14314, USA

    Andrew A. Gage M.D.

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  1. John M. Baust B.S., Ph.D.
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Correspondence to John M. Baust B.S., Ph.D. .

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  1. , Department of Surgery, Duke Cancer Institute, Room 1089 Duke South, Durham, 27710, North Carolina, USA

    Thomas J. Polascik

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Baust, J.M., Santucci, K., Gage, A.A., Robilotto, A. (2013). Optimizing Ablative Therapy: Manipulating the Microenvironment. In: Polascik, T. (eds) Imaging and Focal Therapy of Early Prostate Cancer. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-182-0_26

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  • DOI: https://doi.org/10.1007/978-1-62703-182-0_26

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